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@article{2292957, author = {Ussia, Martina and Urso, Mario and Kratochvílová, Monika and Navrátil, Jiří and Balvan, Jan and MayorgaandMartinez, Carmen C. C. and Vyskocil, Jan and Masařík, Michal and Pumera, Martin}, article_location = {WEINHEIM}, article_number = {17}, doi = {http://dx.doi.org/10.1002/smll.202208259}, keywords = {cysteine; magnetic actuation; micromotors; nanorobots; self-propulsion; tumors}, language = {eng}, issn = {1613-6810}, journal = {SMALL}, title = {Magnetically Driven Self-Degrading Zinc-Containing Cystine Microrobots for Treatment of Prostate Cancer}, url = {https://onlinelibrary.wiley.com/doi/10.1002/smll.202208259}, volume = {19}, year = {2023} }
TY - JOUR ID - 2292957 AU - Ussia, Martina - Urso, Mario - Kratochvílová, Monika - Navrátil, Jiří - Balvan, Jan - Mayorga-Martinez, Carmen C. C. - Vyskocil, Jan - Masařík, Michal - Pumera, Martin PY - 2023 TI - Magnetically Driven Self-Degrading Zinc-Containing Cystine Microrobots for Treatment of Prostate Cancer JF - SMALL VL - 19 IS - 17 SP - 1-12 EP - 1-12 PB - WILEY-V C H VERLAG GMBH SN - 16136810 KW - cysteine KW - magnetic actuation KW - micromotors KW - nanorobots KW - self-propulsion KW - tumors UR - https://onlinelibrary.wiley.com/doi/10.1002/smll.202208259 N2 - Prostate cancer is the most commonly diagnosed tumor disease in men, and its treatment is still a big challenge in standard oncology therapy. Magnetically actuated microrobots represent the most promising technology in modern nanomedicine, offering the advantage of wireless guidance, effective cell penetration, and non-invasive actuation. Here, new biodegradable magnetically actuated zinc/cystine-based microrobots for in situ treatment of prostate cancer cells are reported. The microrobots are fabricated via metal-ion-mediated self-assembly of the amino acid cystine encapsulating superparamagnetic Fe3O4 nanoparticles (NPs) during the synthesis, which allows their precise manipulation by a rotating magnetic field. Inside the cells, the typical enzymatic reducing environment favors the disassembly of the aminoacidic chemical structure due to the cleavage of cystine disulfide bonds and disruption of non-covalent interactions with the metal ions, as demonstrated by in vitro experiments with reduced nicotinamide adenine dinucleotide (NADH). In this way, the cystine microrobots served for site-specific delivery of Zn2+ ions responsible for tumor cell killing via a "Trojan horse effect". This work presents a new concept of cell internalization exploiting robotic systems' self-degradation, proposing a step forward in non-invasive cancer therapy. ER -
USSIA, Martina, Mario URSO, Monika KRATOCHVÍLOVÁ, Jiří NAVRÁTIL, Jan BALVAN, Carmen C. C. MAYORGA-MARTINEZ, Jan VYSKOCIL, Michal MASAŘÍK a Martin PUMERA. Magnetically Driven Self-Degrading Zinc-Containing Cystine Microrobots for Treatment of Prostate Cancer. \textit{SMALL}. WEINHEIM: WILEY-V C H VERLAG GMBH, 2023, roč.~19, č.~17, s.~1-12. ISSN~1613-6810. Dostupné z: https://dx.doi.org/10.1002/smll.202208259.
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