J 2023

Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

GIUSEPPE, De Luca, Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV et. al.

Základní údaje

Originální název

Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Autoři

GIUSEPPE, De Luca (garant), Magdy ALGOWHARY, Berat UGUZ, Dinaldo C OLIVEIRA, Vladimir GANYUKOV, Oliver BUSLJETIK, Miha CERCEK, Lisette Okkels JENSEN, Poay Huan LOH, Lucian CALMAC, Gerard Roura i FERRER, Alexandre QUADROS, Marek MILEWSKI, Fortunato Scotto UCCIO, von Birgelen CLEMENS, Francesco VERSACI, Ten Berg JURRIEN, Gianni CASELLA, Aaron Wong Sung LUNG, Petr KALA (203 Česká republika, domácí), Jose Luis Diez GIL, Xavier CARRILLO, Maurits DIRKSEN, Victor Becerra MUNOZ, Michael Kang-yin LEE, Dafsah Arifa JUZAR, Rodrigo de Joaquim JOAQUIM, Roberto PALADINO, Davor MILICIC, Periklis DAVLOUROS, Nikola BAKRACESKI, Filippo ZILIO, Luca DONAZZAN, Adriaan KRAAIJEVELD, Gennaro GALASSO, Lux ARPAD, Lucia MARINUCCI, Vincenzo GUIDUCCI, Maurizio MENICHELLI, Alessandra SCOCCIA, Aylin Hatice YAMAC, Kadir Ugur MERT, Xacobe Flores RIOS, Tomas KOVARNIK, Michal KIDAWA, Jose MOREU, Vincent FLAVIEN, Enrico FABRIS, Inigo Lozano MARTINEZ-LUENGAS, Marco BOCCALATTE, Francisco Bosa OJEDA, Carlos ARELLANO-SERRANO, Gianluca CAIAZZO, Giuseppe CIRRINCIONE, Hsien-Li KAO, Juan Sanchis FORES, Luigi VIGNALI, Helder PEREIRA, Stephane MANZO-SILBERMAN, Santiago ORDONEZ, Arat Ozkan ALEV, Bruno SCHELLER, Heidi LEHITOLA, Rui TELES, Christos MANTIS, Ylitalo ANTTI, Joao Antonio Brum SILVEIRA, Cesar Rodrigo ZONI, Ivan BESSONOV, Giuseppe UCCELLO, George KOCHIADAKIS, Dimitrios ALEXOPULOS, Carlos E URIBE, John KANAKAKIS, Benjamin FAURIE, Gabriele GABRIELLI, Alejandro Gutierrez BARRIOS, Juan Pablo BACHINI, Alex ROCHA, Frankie C C TAM, Alfredo RODRIGUEZ, Antonia Anna LUKITO, Veauthyelau SAINT-JOY, Gustavo PESSAH, Andrea TUCCILLO, Alfonso IELASI, Giuliana CORTESE, Guido PARODI, Mohammed Abed BURGADHA, Elvin KEDHI, Pablo LAMELAS, Harry SURYAPRANATA, Matteo NARDIN a Monica VERDOIA

Vydání

Journal of Clinical Medicine, Basel, MDPI, 2023, 2077-0383

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 3.900 v roce 2022

Kód RIV

RIV/00216224:14110/23:00131025

Organizační jednotka

Lékařská fakulta

UT WoS

000973288800001

Klíčová slova anglicky

ageing; ST-segment elevation myocardial infarction; COVID-19

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 21. 6. 2023 09:57, Mgr. Tereza Miškechová

Anotace

V originále

Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or >= 75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.