Features of Mpox infection: The analysis of the data submitted
to the ID-IRI network

J 2023

Features of Mpox infection: The analysis of the data submitted to the ID-IRI network

RODRIGUEZ-MORALES, Alfonso J., Antonio CASCIO, Hakan Rana ERDEM, Massimiliano LANZAFAME, Antonella TAMMARO et. al.

Základní údaje

Originální název

Features of Mpox infection: The analysis of the data submitted to the ID-IRI network

Autoři

RODRIGUEZ-MORALES, Alfonso J. (170 Kolumbie), Antonio CASCIO (380 Itálie), Hakan Rana ERDEM (792 Turecko), Massimiliano LANZAFAME (380 Itálie), Antonella TAMMARO (380 Itálie), Iva S. CHRISTOVA (100 Bulharsko), Amani Aly EL KHOLY (818 Egypt), Y. CAG (792 Turecko), Botond LAKATOS (348 Maďarsko), Corneliu Petru POPESCU (642 Rumunsko), A. N. BARBOSA (76 Brazílie), Juan Pablo ESCALERA-ANTEZANA (68 Bolívie), José Arturo MARTÍNEZ-OROZCO (484 Mexiko), Enrique CHACÓN-CRUZ (840 Spojené státy), Hülya ÇAŞKURLU (792 Turecko), Ricardo Coll FERNÁNDEZ (630 Portoriko), Gülden ESER-KARLIDAĞ (792 Turecko), Tarsila VIECELI (76 Brazílie), Stefka T. KRUMOVA (100 Bulharsko), Roman STEBEL (203 Česká republika, garant, domácí), Olumuyiwa Elijah ARIYO (566 Nigérie), Rusmir BALJIĆ (70 Bosna a Hercegovina), Mireia Cairó LLOBELL (724 Španělsko), Éva Livia NAGY (348 Maďarsko), Raúl Adrián CRUZ-FLORES (484 Mexiko), Umran S. ELBAHR (48 Bahrajn), Osasona Oluwadamilola GIDEON (566 Nigérie), Marcelo Felipe BATALLANOS-HUARACHI (68 Bolívie), Philippe BOSSI (250 Francie), Andrea CALDERON-SUAREZ (170 Kolumbie), Ruben CASTILLO-QUINO (68 Bolívie), Christian GOMEZ-DAVILA (68 Bolívie), Mario GOMEZ-ZEPEDA (484 Mexiko), Greisha M. GONZALES (840 Spojené státy), Carlos Eduardo GONZALES-FLORES (68 Bolívie), Andrea GONZALEZ-RODRIGUEZ (840 Spojené státy), Humberto GUDINO-SOLORIO (32 Argentina), Daniela MARTINEZ-NIEVES (724 Španělsko), Miriam MOREIRA-FLORES (68 Bolívie), Augustus OSBORNE (694 Sierra Leone), Pedro PALMA (620 Portugalsko) a Buse TUNCER (792 Turecko)

Vydání

New Microbes and New Infections, Oxford, Elsevier Ltd. 2023, 2052-2975

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

text publikace

Impakt faktor

Impact factor: 4.000 v roce 2022

Kód RIV

RIV/00216224:14110/23:00131056

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.nmni.2023.101154

UT WoS

001044811300001

Klíčová slova česky

mpox; ohnisko; vakcína proti planým neštovicím; mpox u HIV infikovaných

Klíčová slova anglicky

mpox; outbreak; smallpox vaccine; HIV-Infected mpox

Štítky

14110214, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 3. 2024 08:57, Mgr. Tereza Miškechová

Anotace

V originále

Background Mpox is a rare zoonotic disease caused by the Mpox virus. On May 21, 2022, WHO announced the emergence of confirmed Mpox cases in countries outside the endemic areas in Central and West Africa. Methods This multicentre study was performed through the Infectious Diseases International Research Initiative network. Nineteen collaborating centres in 16 countries participated in the study. Consecutive cases with positive Mpoxv-DNA results by the polymerase chain reaction test were included in the study. Results The mean age of 647 patients included in the study was 34.5.98.6% of cases were males, 95.3% were homosexual-bisexual, and 92.2% had a history of sexual contact. History of smallpox vaccination was present in 3.4% of cases. The median incubation period was 7.0 days. The most common symptoms and signs were rashes in 99.5%, lymphadenopathy in 65.1%, and fever in 54.9%. HIV infection was present in 93.8% of cases, and 17.8% were followed up in the hospital for further treatment. In the two weeks before the rash, prodromal symptoms occurred in 52.8% of cases. The incubation period was 3.5 days shorter in HIV-infected Mpox cases with CD4 count <200/μL, we disclosed the presence of lymphadenopathy, a characteristic finding for Mpox, accompanied the disease to a lesser extent in cases with smallpox vaccination. Conclusions Mpox disseminates globally, not just in the endemic areas. Knowledge of clinical features, disease transmission kinetics, and rapid and effective implementation of public health measures are paramount, as reflected by our findings in this study.

Citovat

RODRIGUEZ-MORALES, Alfonso J., Antonio CASCIO, Hakan Rana ERDEM, Massimiliano LANZAFAME, Antonella TAMMARO, Iva S. CHRISTOVA, Amani Aly EL KHOLY, Y. CAG, Botond LAKATOS, Corneliu Petru POPESCU, A. N. BARBOSA, Juan Pablo ESCALERA-ANTEZANA, José Arturo MARTÍNEZ-OROZCO, Enrique CHACÓN-CRUZ, Hülya ÇAŞKURLU, Ricardo Coll FERNÁNDEZ, Gülden ESER-KARLIDAĞ, Tarsila VIECELI, Stefka T. KRUMOVA, Roman STEBEL, Olumuyiwa Elijah ARIYO, Rusmir BALJIĆ, Mireia Cairó LLOBELL, Éva Livia NAGY, Raúl Adrián CRUZ-FLORES, Umran S. ELBAHR, Osasona Oluwadamilola GIDEON, Marcelo Felipe BATALLANOS-HUARACHI, Philippe BOSSI, Andrea CALDERON-SUAREZ, Ruben CASTILLO-QUINO, Christian GOMEZ-DAVILA, Mario GOMEZ-ZEPEDA, Greisha M. GONZALES, Carlos Eduardo GONZALES-FLORES, Andrea GONZALEZ-RODRIGUEZ, Humberto GUDINO-SOLORIO, Daniela MARTINEZ-NIEVES, Miriam MOREIRA-FLORES, Augustus OSBORNE, Pedro PALMA a Buse TUNCER. Features of Mpox infection: The analysis of the data submitted to the ID-IRI network. New Microbes and New Infections. Oxford: Elsevier Ltd., 2023, roč. 53, June, s. 101154-101159. ISSN 2052-2975. Dostupné z: https://dx.doi.org/10.1016/j.nmni.2023.101154.

@article{2293239,
   author = {RodriguezandMorales, Alfonso J. and Cascio, Antonio and Erdem, Hakan Rana and Lanzafame, Massimiliano and Tammaro, Antonella and Christova, Iva S. and El Kholy, Amani Aly and Cag, Y. and Lakatos, Botond and Popescu, Corneliu Petru and Barbosa, A. N. and EscaleraandAntezana, Juan Pablo and MartínezandOrozco, José Arturo and ChacónandCruz, Enrique and Çaşkurlu, Hülya and Fernández, Ricardo Coll and EserandKarlıdağ, Gülden and Vieceli, Tarsila and Krumova, Stefka T. and Stebel, Roman and Ariyo, Olumuyiwa Elijah and Baljić, Rusmir and Llobell, Mireia Cairó and Nagy, Éva Livia and CruzandFlores, Raúl Adrián and Elbahr, Umran S. and Gideon, Osasona Oluwadamilola and BatallanosandHuarachi, Marcelo Felipe and Bossi, Philippe and CalderonandSuarez, Andrea and CastilloandQuino, Ruben and GomezandDavila, Christian and GomezandZepeda, Mario and Gonzales, Greisha M. and GonzalesandFlores, Carlos Eduardo and GonzalezandRodriguez, Andrea and GudinoandSolorio, Humberto and MartinezandNieves, Daniela and MoreiraandFlores, Miriam and Osborne, Augustus and Palma, Pedro and Tuncer, Buse},
   article_location = {Oxford},
   article_number = {June},
   doi = {http://dx.doi.org/10.1016/j.nmni.2023.101154},
   keywords = {mpox; outbreak; smallpox vaccine; HIV-Infected mpox},
   language = {eng},
   issn = {2052-2975},
   journal = {New Microbes and New Infections},
   title = {Features of Mpox infection: The analysis of the data submitted to the ID-IRI network},
   url = {https://www.sciencedirect.com/science/article/pii/S2052297523000732?via%3Dihub},
   volume = {53},
   year = {2023}
}

TY  - JOUR
ID  - 2293239
AU  - Rodriguez-Morales, Alfonso J. - Cascio, Antonio - Erdem, Hakan Rana - Lanzafame, Massimiliano - Tammaro, Antonella - Christova, Iva S. - El Kholy, Amani Aly - Cag, Y. - Lakatos, Botond - Popescu, Corneliu Petru - Barbosa, A. N. - Escalera-Antezana, Juan Pablo - Martínez-Orozco, José Arturo - Chacón-Cruz, Enrique - Çaşkurlu, Hülya - Fernández, Ricardo Coll - Eser-Karlıdağ, Gülden - Vieceli, Tarsila - Krumova, Stefka T. - Stebel, Roman - Ariyo, Olumuyiwa Elijah - Baljić, Rusmir - Llobell, Mireia Cairó - Nagy, Éva Livia - Cruz-Flores, Raúl Adrián - Elbahr, Umran S. - Gideon, Osasona Oluwadamilola - Batallanos-Huarachi, Marcelo Felipe - Bossi, Philippe - Calderon-Suarez, Andrea - Castillo-Quino, Ruben - Gomez-Davila, Christian - Gomez-Zepeda, Mario - Gonzales, Greisha M. - Gonzales-Flores, Carlos Eduardo - Gonzalez-Rodriguez, Andrea - Gudino-Solorio, Humberto - Martinez-Nieves, Daniela - Moreira-Flores, Miriam - Osborne, Augustus - Palma, Pedro - Tuncer, Buse
PY  - 2023
TI  - Features of Mpox infection: The analysis of the data submitted to the ID-IRI network
JF  - New Microbes and New Infections
VL  - 53
IS  - June
SP  - 101154
EP  - 101154
PB  - Elsevier Ltd.
SN  - 20522975
KW  - mpox
KW  - outbreak
KW  - smallpox vaccine
KW  - HIV-Infected mpox
UR  - https://www.sciencedirect.com/science/article/pii/S2052297523000732?via%3Dihub
N2  - Background Mpox is a rare zoonotic disease caused by the Mpox virus. On May 21, 2022, WHO announced the emergence of confirmed Mpox cases in countries outside the endemic areas in Central and West Africa. Methods This multicentre study was performed through the Infectious Diseases International Research Initiative network. Nineteen collaborating centres in 16 countries participated in the study. Consecutive cases with positive Mpoxv-DNA results by the polymerase chain reaction test were included in the study. Results The mean age of 647 patients included in the study was 34.5.98.6% of cases were males, 95.3% were homosexual-bisexual, and 92.2% had a history of sexual contact. History of smallpox vaccination was present in 3.4% of cases. The median incubation period was 7.0 days. The most common symptoms and signs were rashes in 99.5%, lymphadenopathy in 65.1%, and fever in 54.9%. HIV infection was present in 93.8% of cases, and 17.8% were followed up in the hospital for further treatment. In the two weeks before the rash, prodromal symptoms occurred in 52.8% of cases. The incubation period was 3.5 days shorter in HIV-infected Mpox cases with CD4 count <200/μL, we disclosed the presence of lymphadenopathy, a characteristic finding for Mpox, accompanied the disease to a lesser extent in cases with smallpox vaccination. Conclusions Mpox disseminates globally, not just in the endemic areas. Knowledge of clinical features, disease transmission kinetics, and rapid and effective implementation of public health measures are paramount, as reflected by our findings in this study.
ER  -

RODRIGUEZ-MORALES, Alfonso J., Antonio CASCIO, Hakan Rana ERDEM, Massimiliano LANZAFAME, Antonella TAMMARO, Iva S. CHRISTOVA, Amani Aly EL KHOLY, Y. CAG, Botond LAKATOS, Corneliu Petru POPESCU, A. N. BARBOSA, Juan Pablo ESCALERA-ANTEZANA, José Arturo MARTÍNEZ-OROZCO, Enrique CHACÓN-CRUZ, Hülya $\backslash$C CA$\backslash$C SKURLU, Ricardo Coll FERNÁNDEZ, Gülden ESER-KARLIDAĞ, Tarsila VIECELI, Stefka T. KRUMOVA, Roman STEBEL, Olumuyiwa Elijah ARIYO, Rusmir BALJI$\backslash$'C, Mireia Cairó LLOBELL, Éva Livia NAGY, Raúl Adrián CRUZ-FLORES, Umran S. ELBAHR, Osasona Oluwadamilola GIDEON, Marcelo Felipe BATALLANOS-HUARACHI, Philippe BOSSI, Andrea CALDERON-SUAREZ, Ruben CASTILLO-QUINO, Christian GOMEZ-DAVILA, Mario GOMEZ-ZEPEDA, Greisha M. GONZALES, Carlos Eduardo GONZALES-FLORES, Andrea GONZALEZ-RODRIGUEZ, Humberto GUDINO-SOLORIO, Daniela MARTINEZ-NIEVES, Miriam MOREIRA-FLORES, Augustus OSBORNE, Pedro PALMA a Buse TUNCER. Features of Mpox infection: The analysis of the data submitted to the ID-IRI network. \textit{New Microbes and New Infections}. Oxford: Elsevier Ltd., 2023, roč.~53, June, s.~101154-101159. ISSN~2052-2975. Dostupné z: https://dx.doi.org/10.1016/j.nmni.2023.101154.

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