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@article{2293480,
author = {Ondruššek, Róbert and Kvokačková, Barbora and Kryštofová, Karolína and Brychtová, Světlana and Souček, Karel and Bouchal, Jan},
article_location = {Lausanne},
article_number = {March 2023},
doi = {http://dx.doi.org/10.3389/fonc.2023.1140738},
keywords = {CD9; cancer; immunohistochemistry; prognosis; exosomes},
language = {eng},
issn = {2234-943X},
journal = {Frontiers in Oncology},
title = {Prognostic value and multifaceted roles of tetraspanin CD9 in cancer},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2023.1140738/full},
volume = {13},
year = {2023}
}
TY - JOUR
ID - 2293480
AU - Ondruššek, Róbert - Kvokačková, Barbora - Kryštofová, Karolína - Brychtová, Světlana - Souček, Karel - Bouchal, Jan
PY - 2023
TI - Prognostic value and multifaceted roles of tetraspanin CD9 in cancer
JF - Frontiers in Oncology
VL - 13
IS - March 2023
SP - 1-11
EP - 1-11
PB - Frontiers Media S.A.
SN - 2234943X
KW - CD9
KW - cancer
KW - immunohistochemistry
KW - prognosis
KW - exosomes
UR - https://www.frontiersin.org/articles/10.3389/fonc.2023.1140738/full
N2 - CD9 is a crucial regulator of cell adhesion in the immune system and plays important physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is involved in the transendothelial migration of leukocytes which might also be hijacked by cancer cells during their invasion and metastasis. CD9 is found at the cell surface and the membrane of exosomes affecting cancer progression and therapy resistance. High expression of CD9 is mostly associated with good patients outcome, with a few exceptions. Discordant findings have been reported for breast, ovarian, melanoma, pancreatic and esophageal cancer, which might be related to using different antibodies or inherent cancer heterogeneity. According to in vitro and in vivo studies, tetraspanin CD9 is not clearly associated with either tumor suppression or promotion. Further mechanistic experiments will elucidate the role of CD9 in particular cancer types and specific conditions.
ER -
ONDRUŠŠEK, Róbert, Barbora KVOKAČKOVÁ, Karolína KRYŠTOFOVÁ, Světlana BRYCHTOVÁ, Karel SOUČEK a Jan BOUCHAL. Prognostic value and multifaceted roles of tetraspanin CD9 in cancer. \textit{Frontiers in Oncology}. Lausanne: Frontiers Media S.A., 2023, roč.~13, March 2023, s.~1-11. ISSN~2234-943X. Dostupné z: https://dx.doi.org/10.3389/fonc.2023.1140738.
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