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@article{2294900,
author = {Lav, Rupali and Křivánek, Jan and Anthwal, Neal and Tucker, Abigail S.},
article_location = {CAMBRIDGE},
article_number = {4},
doi = {http://dx.doi.org/10.1016/j.stemcr.2023.02.004},
keywords = {stem cells; development; homeostasis; Wnt signaling; tooth development; tooth defects; Hh signaling; Sox9},
language = {eng},
issn = {2213-6711},
journal = {STEM CELL REPORTS},
title = {Wnt signaling from Gli1-expressing apical stem/progenitor cells is essential for the coordination of tooth root development},
url = {https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(23)00051-6},
volume = {18},
year = {2023}
}
TY - JOUR
ID - 2294900
AU - Lav, Rupali - Křivánek, Jan - Anthwal, Neal - Tucker, Abigail S.
PY - 2023
TI - Wnt signaling from Gli1-expressing apical stem/progenitor cells is essential for the coordination of tooth root development
JF - STEM CELL REPORTS
VL - 18
IS - 4
SP - 1015-1029
EP - 1015-1029
PB - CELL PRESS
SN - 22136711
KW - stem cells
KW - development
KW - homeostasis
KW - Wnt signaling
KW - tooth development
KW - tooth defects
KW - Hh signaling
KW - Sox9
UR - https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(23)00051-6
N2 - Stem cell regulation plays a crucial role during development and homeostasis. Here, an essential source of Wnts from Gli1+ stem/progenitor cells was identified in the murine molar. Loss of Wnt production in Gli1+ apical stem/progenitor cells led to loss of Axin2 at the root apex, mis-regulation of SOX9, loss of BMP and Hh signaling, and truncation of root development. In the absence of Wnt signals, the root epithelium lost its integrity and epithelial identity. This phenotype could be partially mimicked by loss of Sox9 in the Gli1 population. Stabilization of Wnt signaling in the apical papilla led to rapid unordered differentiation of hard tissues and fragmentation of the epithelial root sheath. Wnt signaling from Gli1+ stem/progenitor cells, therefore, orchestrates root development, coordinating mesenchymal and epithelial interactions via SOX9 to regulate stem/progenitor cell expansion and differentiation. Our results demonstrate that disparate stem/progenitor cell populations are unified in their fundamental signaling interactions.
ER -
LAV, Rupali, Jan KŘIVÁNEK, Neal ANTHWAL a Abigail S. TUCKER. Wnt signaling from Gli1-expressing apical stem/progenitor cells is essential for the coordination of tooth root development. \textit{STEM CELL REPORTS}. CAMBRIDGE: CELL PRESS, 2023, roč.~18, č.~4, s.~1015-1029. ISSN~2213-6711. Dostupné z: https://dx.doi.org/10.1016/j.stemcr.2023.02.004.
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