RAUDENSKÁ, Martina, Jan BALVAN, Klára HÁNĚLOVÁ, Mária BUGAJOVÁ and Michal MASAŘÍK. Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. AMSTERDAM: ELSEVIER, 2023, vol. 1878, No 5, p. 1-12. ISSN 0304-419X. Available from: https://dx.doi.org/10.1016/j.bbcan.2023.188940.
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Basic information
Original name Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling
Authors RAUDENSKÁ, Martina (203 Czech Republic, belonging to the institution), Jan BALVAN (203 Czech Republic, belonging to the institution), Klára HÁNĚLOVÁ (203 Czech Republic, belonging to the institution), Mária BUGAJOVÁ (703 Slovakia, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution).
Edition Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, AMSTERDAM, ELSEVIER, 2023, 0304-419X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30204 Oncology
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 11.200 in 2022
RIV identification code RIV/00216224:14110/23:00131127
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.bbcan.2023.188940
UT WoS 001057815400001
Keywords in English Head and neck cancer; Cancer-associated fibroblasts; Cancer therapy; Tumor microenvironment; Resistance to therapy
Tags 14110515, 14110518, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 25/1/2024 14:00.
Abstract
Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.
Links
GA21-06873S, research and development projectName: Metabolická symbióza mezi nádorovými buňkami a fibroblasty asociovaných s nádorem u nádorů v oblasti hlavy a krku
Investor: Czech Science Foundation
MUNI/A/1343/2022, interní kód MUName: Zátěže kardiovaskulárního systému od A po Z
Investor: Masaryk University, Loads on the cardiovascular system from A to Z
MUNI/A/1370/2022, interní kód MUName: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň
Investor: Masaryk University, Pathophysiology of selected complex diseases from molecular to systemic level
NU22-03-00202, research and development projectName: Proteom extracelulárních vezikul - neprozkoumaná oblast mezibuněčné komunikace v mikroprostředí nádorů hlavy a krku
Investor: Ministry of Health of the CR, Subprogram 1 - standard
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