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@article{2295031, author = {Ballonová, Lucie and Kulíšková, Petra and Slanina, Peter and Štíchová, Julie and Vlková, Marcela and Hakl, Roman and Litzman, Jiří and Souček, Přemysl and Freiberger, Tomáš}, article_location = {DORDRECHT}, article_number = {6}, doi = {http://dx.doi.org/10.1007/s11033-023-08391-8}, keywords = {PLAUR; uPAR; HAE; Differentiation; Monocyte; Macrophages}, language = {eng}, issn = {0301-4851}, journal = {Molecular Biology Reports}, title = {PLAUR splicing pattern in hereditary angioedema patients' monocytes and macrophages}, url = {https://link.springer.com/article/10.1007/s11033-023-08391-8}, volume = {50}, year = {2023} }
TY - JOUR ID - 2295031 AU - Ballonová, Lucie - Kulíšková, Petra - Slanina, Peter - Štíchová, Julie - Vlková, Marcela - Hakl, Roman - Litzman, Jiří - Souček, Přemysl - Freiberger, Tomáš PY - 2023 TI - PLAUR splicing pattern in hereditary angioedema patients' monocytes and macrophages JF - Molecular Biology Reports VL - 50 IS - 6 SP - 4975-4982 EP - 4975-4982 PB - Springer SN - 03014851 KW - PLAUR KW - uPAR KW - HAE KW - Differentiation KW - Monocyte KW - Macrophages UR - https://link.springer.com/article/10.1007/s11033-023-08391-8 N2 - BackgroundThe PLAUR gene encodes the urokinase-like plasminogen activator receptor (uPAR) and may undergo alternative splicing. Excluding cassette exons 3, 5 and 6 from the transcript results in truncated protein variants whose precise functions have not been elucidated yet. The PLAUR gene is one of several expressed in myeloid cells, where uPAR participates in different cellular processes, including the contact activation system and kallikrein-kinin system, which play an important role in hereditary angioedema (HAE) pathogenesis. A hypothesis about the PLAUR splicing pattern impact on HAE severity was tested.Methods and resultsThe RT-PCR quantified by capillary electrophoresis was used. Although no significant difference in alternative transcript frequency was observed between healthy volunteers and HAE patients, a significant increase in all cassette exon inclusion variants was revealed during monocyte-to-macrophage differentiation.ConclusionsPLAUR alternative splicing in monocytes and macrophages neither was different between HAE patients and healthy controls, nor reflected disease severity. However, the results showed an PLAUR splicing pattern was changing during monocyte-to-macrophage differentiation, but the significance of these changes is unknown and awaits future clarification. ER -
BALLONOVÁ, Lucie, Petra KULÍŠKOVÁ, Peter SLANINA, Julie ŠTÍCHOVÁ, Marcela VLKOVÁ, Roman HAKL, Jiří LITZMAN, Přemysl SOUČEK a Tomáš FREIBERGER. PLAUR splicing pattern in hereditary angioedema patients' monocytes and macrophages. \textit{Molecular Biology Reports}. DORDRECHT: Springer, 2023, roč.~50, č.~6, s.~4975-4982. ISSN~0301-4851. Dostupné z: https://dx.doi.org/10.1007/s11033-023-08391-8.
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