Multi-omics signatures in new-onset diabetes predict metabolic
response to dietary inulin: findings from an observational
study followed by an interventional trial

J 2023

Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial

DASKOVA, N., I. MODOS, M. KRBCOVA, M. KUZMA, H. PELANTOVA et. al.

Základní údaje

Originální název

Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial

Autoři

DASKOVA, N., I. MODOS, M. KRBCOVA, M. KUZMA, H. PELANTOVA, J. HRADECKY, M. HECZKOVA, M. BRATOVA, Petra VÍDEŇSKÁ (203 Česká republika), Petra ŠPLÍCHALOVÁ (203 Česká republika, domácí), Maria KRÁLOVÁ (203 Česká republika), M. HENIKOVA, J. POTOCKOVA, A. OURADOVA, R. LANDBERG, T. KUEHN, M. CAHOVA a J. GOJDA

Vydání

NUTRITION & DIABETES, LONDON, SPRINGERNATURE, 2023, 2044-4052

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30308 Nutrition, Dietetics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.100 v roce 2022

Kód RIV

RIV/00216224:14310/23:00131163

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/s41387-023-00235-5

UT WoS

000975357800002

Klíčová slova anglicky

CHAIN FATTY-ACIDS; GUT MICROBIOTA; INSULIN-SECRETION; FERMENTATION; METAGENOME; INCREASES; CAPACITY; DILUTION; OBESITY; FIBER

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 1. 2024 19:27, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

AimThe metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ across metabolic spectra (lean-obese-diabetes); (2) that specific MIME patterns could explain the differential responses to dietary inulin; and (3) that the response can be predicted based on baseline MIME signature and clinical characteristics.MethodForty-nine patients with newly diagnosed pre/diabetes (DM), 66 metabolically healthy overweight/obese (OB), and 32 healthy lean (LH) volunteers were compared in a cross-sectional case-control study integrating clinical variables, dietary intake, gut microbiome, and fecal/serum metabolomes (16 S rRNA sequencing, metabolomics profiling). Subsequently, 27 DM were recruited for a predictive study: 3 months of dietary inulin (10 g/day) intervention.ResultsMIME composition was different between groups. While the DM and LH groups represented opposite poles of the abundance spectrum, OB was closer to DM. Inulin supplementation was associated with an overall improvement in glycemic indices, though the response was very variable, with a shift in microbiome composition toward a more favorable profile and increased serum butyric and propionic acid concentrations. The improved glycemic outcomes of inulin treatment were dependent on better baseline glycemic status and variables related to the gut microbiota, including the abundance of certain bacterial taxa (i.e., Blautia, Eubacterium halii group, Lachnoclostridium, Ruminiclostridium, Dialister, or Phascolarctobacterium), serum concentrations of branched-chain amino acid derivatives and asparagine, and fecal concentrations of indole and several other volatile organic compounds.ConclusionWe demonstrated that obesity is a stronger determinant of different MIME patterns than impaired glucose metabolism. The large inter-individual variability in the metabolic effects of dietary inulin was explained by differences in baseline glycemic status and MIME signatures. These could be further validated to personalize nutritional interventions in patients with newly diagnosed diabetes.

Návaznosti

LX22NPO5104, projekt VaV

Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES

Přiložené soubory

2296179.pdf

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Citovat

DASKOVA, N., I. MODOS, M. KRBCOVA, M. KUZMA, H. PELANTOVA, J. HRADECKY, M. HECZKOVA, M. BRATOVA, Petra VÍDEŇSKÁ, Petra ŠPLÍCHALOVÁ, Maria KRÁLOVÁ, M. HENIKOVA, J. POTOCKOVA, A. OURADOVA, R. LANDBERG, T. KUEHN, M. CAHOVA a J. GOJDA. Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial. NUTRITION & DIABETES. LONDON: SPRINGERNATURE, 2023, roč. 13, č. 1, s. 1-13. ISSN 2044-4052. Dostupné z: https://dx.doi.org/10.1038/s41387-023-00235-5.

@article{2296179,
   author = {Daskova, N. and Modos, I. and Krbcova, M. and Kuzma, M. and Pelantova, H. and Hradecky, J. and Heczkova, M. and Bratova, M. and Vídeňská, Petra and Šplíchalová, Petra and Králová, Maria and Henikova, M. and Potockova, J. and Ouradova, A. and Landberg, R. and Kuehn, T. and Cahova, M. and Gojda, J.},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41387-023-00235-5},
   keywords = {CHAIN FATTY-ACIDS; GUT MICROBIOTA; INSULIN-SECRETION; FERMENTATION; METAGENOME; INCREASES; CAPACITY; DILUTION; OBESITY; FIBER},
   language = {eng},
   issn = {2044-4052},
   journal = {NUTRITION & DIABETES},
   title = {Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial},
   url = {https://www.nature.com/articles/s41387-023-00235-5},
   volume = {13},
   year = {2023}
}

TY  - JOUR
ID  - 2296179
AU  - Daskova, N. - Modos, I. - Krbcova, M. - Kuzma, M. - Pelantova, H. - Hradecky, J. - Heczkova, M. - Bratova, M. - Vídeňská, Petra - Šplíchalová, Petra - Králová, Maria - Henikova, M. - Potockova, J. - Ouradova, A. - Landberg, R. - Kuehn, T. - Cahova, M. - Gojda, J.
PY  - 2023
TI  - Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial
JF  - NUTRITION & DIABETES
VL  - 13
IS  - 1
SP  - 1-13
EP  - 1-13
PB  - SPRINGERNATURE
SN  - 20444052
KW  - CHAIN FATTY-ACIDS
KW  - GUT MICROBIOTA
KW  - INSULIN-SECRETION
KW  - FERMENTATION
KW  - METAGENOME
KW  - INCREASES
KW  - CAPACITY
KW  - DILUTION
KW  - OBESITY
KW  - FIBER
UR  - https://www.nature.com/articles/s41387-023-00235-5
N2  - AimThe metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ across metabolic spectra (lean-obese-diabetes); (2) that specific MIME patterns could explain the differential responses to dietary inulin; and (3) that the response can be predicted based on baseline MIME signature and clinical characteristics.MethodForty-nine patients with newly diagnosed pre/diabetes (DM), 66 metabolically healthy overweight/obese (OB), and 32 healthy lean (LH) volunteers were compared in a cross-sectional case-control study integrating clinical variables, dietary intake, gut microbiome, and fecal/serum metabolomes (16 S rRNA sequencing, metabolomics profiling). Subsequently, 27 DM were recruited for a predictive study: 3 months of dietary inulin (10 g/day) intervention.ResultsMIME composition was different between groups. While the DM and LH groups represented opposite poles of the abundance spectrum, OB was closer to DM. Inulin supplementation was associated with an overall improvement in glycemic indices, though the response was very variable, with a shift in microbiome composition toward a more favorable profile and increased serum butyric and propionic acid concentrations. The improved glycemic outcomes of inulin treatment were dependent on better baseline glycemic status and variables related to the gut microbiota, including the abundance of certain bacterial taxa (i.e., Blautia, Eubacterium halii group, Lachnoclostridium, Ruminiclostridium, Dialister, or Phascolarctobacterium), serum concentrations of branched-chain amino acid derivatives and asparagine, and fecal concentrations of indole and several other volatile organic compounds.ConclusionWe demonstrated that obesity is a stronger determinant of different MIME patterns than impaired glucose metabolism. The large inter-individual variability in the metabolic effects of dietary inulin was explained by differences in baseline glycemic status and MIME signatures. These could be further validated to personalize nutritional interventions in patients with newly diagnosed diabetes.
ER  -

DASKOVA, N., I. MODOS, M. KRBCOVA, M. KUZMA, H. PELANTOVA, J. HRADECKY, M. HECZKOVA, M. BRATOVA, Petra VÍDEŇSKÁ, Petra ŠPLÍCHALOVÁ, Maria KRÁLOVÁ, M. HENIKOVA, J. POTOCKOVA, A. OURADOVA, R. LANDBERG, T. KUEHN, M. CAHOVA a J. GOJDA. Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial. \textit{NUTRITION \&{}amp; DIABETES}. LONDON: SPRINGERNATURE, 2023, roč.~13, č.~1, s.~1-13. ISSN~2044-4052. Dostupné z: https://dx.doi.org/10.1038/s41387-023-00235-5.

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