Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols
from inland freshwater bodies and their effects on human
bronchial cells

J 2023

Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells

LABOHÁ, Petra, Eliška SYCHROVÁ, Ondřej BRÓZMAN, Iva SOVADINOVÁ, Lucie BLÁHOVÁ et. al.

Základní údaje

Originální název

Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells

Autoři

LABOHÁ, Petra (203 Česká republika, domácí), Eliška SYCHROVÁ (203 Česká republika, domácí), Ondřej BRÓZMAN (203 Česká republika, domácí), Iva SOVADINOVÁ (203 Česká republika, domácí), Lucie BLÁHOVÁ (203 Česká republika, domácí), Roman PROKEŠ (203 Česká republika, domácí), Jakub ONDRACEK a Pavel BABICA (203 Česká republika, garant, domácí)

Vydání

Environmental Toxicology and Pharmacology, Amsterdam, Elsevier Science B.V. 2023, 1382-6689

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300 v roce 2022

Kód RIV

RIV/00216224:14310/23:00131169

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.etap.2023.104073

UT WoS

000939770800001

Klíčová slova anglicky

Aerosol; Cyanobacteria; Cyanotoxins; Lipopolysaccharides; Inflammation; Inhalation toxicity

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 3. 2024 23:08, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Components of cyanobacterial water blooms were quantified in aerosols above agitated water surfaces of five freshwater bodies. The thoracic and respirable aerosol fraction (0.1-10 mu m) was sampled using a high-volume sampler. Cyanotoxins microcystins were detected by LC-MS/MS at levels 0.3-13.5 ng/mL (water) and < 35-415 fg/m3 (aerosol). Lipopolysaccharides (endotoxins) were quantified by Pyrogene rFC assay at levels < 10-119 EU/mL (water) and 0.13-0.64 EU/m3 (aerosol). Cyanobacterial DNA was detected by qPCR at con-centrations corresponding to 104-105 cells eq./mL (water) and 101-103 cells eq./m3 (aerosol). Lipopolysac-charides isolated from bloom samples induced IL-6 and IL-8 cytokine release in human bronchial epithelial cells Beas-2B, while extracted cyanobacterial metabolites induced both pro-inflammatory and cytotoxic effects. Bloom components detected in aerosols and their bioactivities observed in upper respiratory airway epithelial cells together indicate that aerosols formed during cyanobacterial water blooms could induce respiratory irritation and inflammatory injuries, and thus present an inhalation health risk.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

GJ17-25279Y, projekt VaV

Název: Zdravotní rizika spojená s inhalací sinic

Investor: Grantová agentura ČR, Zdravotní rizika spojená s inhalací sinic

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Citovat

LABOHÁ, Petra, Eliška SYCHROVÁ, Ondřej BRÓZMAN, Iva SOVADINOVÁ, Lucie BLÁHOVÁ, Roman PROKEŠ, Jakub ONDRACEK a Pavel BABICA. Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells. Environmental Toxicology and Pharmacology. Amsterdam: Elsevier Science B.V., 2023, roč. 98, March 2023, s. 1-15. ISSN 1382-6689. Dostupné z: https://dx.doi.org/10.1016/j.etap.2023.104073.

@article{2296306,
   author = {Labohá, Petra and Sychrová, Eliška and Brózman, Ondřej and Sovadinová, Iva and Bláhová, Lucie and Prokeš, Roman and Ondracek, Jakub and Babica, Pavel},
   article_location = {Amsterdam},
   article_number = {March 2023},
   doi = {http://dx.doi.org/10.1016/j.etap.2023.104073},
   keywords = {Aerosol; Cyanobacteria; Cyanotoxins; Lipopolysaccharides; Inflammation; Inhalation toxicity},
   language = {eng},
   issn = {1382-6689},
   journal = {Environmental Toxicology and Pharmacology},
   title = {Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells},
   url = {https://www.sciencedirect.com/science/article/pii/S1382668923000145?via%3Dihub},
   volume = {98},
   year = {2023}
}

TY  - JOUR
ID  - 2296306
AU  - Labohá, Petra - Sychrová, Eliška - Brózman, Ondřej - Sovadinová, Iva - Bláhová, Lucie - Prokeš, Roman - Ondracek, Jakub - Babica, Pavel
PY  - 2023
TI  - Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells
JF  - Environmental Toxicology and Pharmacology
VL  - 98
IS  - March 2023
SP  - 1-15
EP  - 1-15
PB  - Elsevier Science B.V.
SN  - 13826689
KW  - Aerosol
KW  - Cyanobacteria
KW  - Cyanotoxins
KW  - Lipopolysaccharides
KW  - Inflammation
KW  - Inhalation toxicity
UR  - https://www.sciencedirect.com/science/article/pii/S1382668923000145?via%3Dihub
N2  - Components of cyanobacterial water blooms were quantified in aerosols above agitated water surfaces of five freshwater bodies. The thoracic and respirable aerosol fraction (0.1-10 mu m) was sampled using a high-volume sampler. Cyanotoxins microcystins were detected by LC-MS/MS at levels 0.3-13.5 ng/mL (water) and < 35-415 fg/m3 (aerosol). Lipopolysaccharides (endotoxins) were quantified by Pyrogene rFC assay at levels < 10-119 EU/mL (water) and 0.13-0.64 EU/m3 (aerosol). Cyanobacterial DNA was detected by qPCR at con-centrations corresponding to 104-105 cells eq./mL (water) and 101-103 cells eq./m3 (aerosol). Lipopolysac-charides isolated from bloom samples induced IL-6 and IL-8 cytokine release in human bronchial epithelial cells Beas-2B, while extracted cyanobacterial metabolites induced both pro-inflammatory and cytotoxic effects. Bloom components detected in aerosols and their bioactivities observed in upper respiratory airway epithelial cells together indicate that aerosols formed during cyanobacterial water blooms could induce respiratory irritation and inflammatory injuries, and thus present an inhalation health risk.
ER  -

LABOHÁ, Petra, Eliška SYCHROVÁ, Ondřej BRÓZMAN, Iva SOVADINOVÁ, Lucie BLÁHOVÁ, Roman PROKEŠ, Jakub ONDRACEK a Pavel BABICA. Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells. \textit{Environmental Toxicology and Pharmacology}. Amsterdam: Elsevier Science B.V., 2023, roč.~98, March 2023, s.~1-15. ISSN~1382-6689. Dostupné z: https://dx.doi.org/10.1016/j.etap.2023.104073.

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