The effect of intrapartum antibiotics prophylaxis on neonatal gut and oral bacteriome

PIVRNCOVÁ, Eliška, Iva KOTÁSKOVÁ, Lucie BUREŠOVÁ, Lenka ANDRÝSKOVÁ, Pavel PILER, Petr JANKŮ, Ivo BOREK, Jana KLÁNOVÁ, Petra VÍDEŇSKÁ, Eva BUDINSKÁ and Petra BOŘILOVÁ LINHARTOVÁ. The effect of intrapartum antibiotics prophylaxis on neonatal gut and oral bacteriome. In RECETOX PhD Conference 2023. 2023.

Basic information

• Original name: The effect of intrapartum antibiotics prophylaxis on neonatal gut and oral bacteriome
• Authors: PIVRNCOVÁ, Eliška (203 Czech Republic, belonging to the institution), Iva KOTÁSKOVÁ (203 Czech Republic), Lucie BUREŠOVÁ (203 Czech Republic), Lenka ANDRÝSKOVÁ (203 Czech Republic), Pavel PILER (203 Czech Republic), Petr JANKŮ (203 Czech Republic), Ivo BOREK (203 Czech Republic), Jana KLÁNOVÁ (203 Czech Republic), Petra VÍDEŇSKÁ (203 Czech Republic), Eva BUDINSKÁ (703 Slovakia) and Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, guarantor).
• Edition: RECETOX PhD Conference 2023, 2023.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10608 Biochemistry and molecular biology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/23:00131175
• Organization unit: Faculty of Science
• Keywords in English: antibiotics prophylaxis;neonatal gut;oral bacteriome

Abstract

The administration of intrapartum antibiotics prophylaxis (IAP) is commonly used in cesarean section and for the prevention of early-onset Group-B-streptococci infection. Since IAP may influence the microbiome development in neonates, our pilot study aimed to characterize the gut and oral bacteriome changes between neonates grouped according to their exposure to antibiotics during the delivery and sampling time in the first week of their life. 16S rDNA sequencing revealed differences in bacterial abundance in transitional stool samples, but not in meconium samples. Moreover, IAP influenced the oral bacteriome of neonates within 48 hours after birth. However, the effect of IAP on oral bacteriome seems to be suppressed later in the first week of their life.

Links

• EF17_043/0009632, research and development project: Name: CETOCOEN Excellence
• LM2018132, research and development project: Name: Národní centrum lékařské genomiky (Acronym: NCLG)

Investor: Ministry of Education, Youth and Sports of the CR, National Center for Medical Genomics

• LM2018140, research and development project: Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)

Investor: Ministry of Education, Youth and Sports of the CR

• LM2023069, research and development project: Name: Výzkumná infrastruktura RECETOX

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX research infrastructure