MASURI, Sebastiano, Lukáš MORÁŇ, Tereza VESSELÁ, Enzo CADONI, Maria Grazia CABIDDU, Lukáš PEČINKA, Viktorie GABRIELOVÁ, Francesca MELONI, Josef HAVEL, Petr VAŇHARA a Tiziana PIVETTA. A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines. Journal of Inorganic Biochemistry. New York: Elsevier, 2023, roč. 246, September 2023, s. 1-14. ISSN 0162-0134. Dostupné z: https://dx.doi.org/10.1016/j.jinorgbio.2023.112301. |
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@article{2296867, author = {Masuri, Sebastiano and Moráň, Lukáš and Vesselá, Tereza and Cadoni, Enzo and Cabiddu, Maria Grazia and Pečinka, Lukáš and Gabrielová, Viktorie and Meloni, Francesca and Havel, Josef and Vaňhara, Petr and Pivetta, Tiziana}, article_location = {New York}, article_number = {September 2023}, doi = {http://dx.doi.org/10.1016/j.jinorgbio.2023.112301}, keywords = {Copper complex; Solution equilibria; Mass spectrometry; Lipoxygenase; Molecular docking; ER stress}, language = {eng}, issn = {0162-0134}, journal = {Journal of Inorganic Biochemistry}, title = {A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines}, url = {https://doi.org/10.1016/j.jinorgbio.2023.112301}, volume = {246}, year = {2023} }
TY - JOUR ID - 2296867 AU - Masuri, Sebastiano - Moráň, Lukáš - Vesselá, Tereza - Cadoni, Enzo - Cabiddu, Maria Grazia - Pečinka, Lukáš - Gabrielová, Viktorie - Meloni, Francesca - Havel, Josef - Vaňhara, Petr - Pivetta, Tiziana PY - 2023 TI - A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines JF - Journal of Inorganic Biochemistry VL - 246 IS - September 2023 SP - 1-14 EP - 1-14 PB - Elsevier SN - 01620134 KW - Copper complex KW - Solution equilibria KW - Mass spectrometry KW - Lipoxygenase KW - Molecular docking KW - ER stress UR - https://doi.org/10.1016/j.jinorgbio.2023.112301 N2 - A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints. ER -
MASURI, Sebastiano, Lukáš MORÁŇ, Tereza VESSELÁ, Enzo CADONI, Maria Grazia CABIDDU, Lukáš PEČINKA, Viktorie GABRIELOVÁ, Francesca MELONI, Josef HAVEL, Petr VAŇHARA a Tiziana PIVETTA. A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines. \textit{Journal of Inorganic Biochemistry}. New York: Elsevier, 2023, roč.~246, September 2023, s.~1-14. ISSN~0162-0134. Dostupné z: https://dx.doi.org/10.1016/j.jinorgbio.2023.112301.
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