Painless form of chronic pancreatitis-multicentre study

J 2023

Painless form of chronic pancreatitis-multicentre study

DITE, Petr, Marie PRECECHTELOVA, Martina BOJKOVA, Martin LOVECEK, Radek AMBROZ et. al.

Základní údaje

Originální název

Painless form of chronic pancreatitis-multicentre study

Autoři

DITE, Petr (203 Česká republika, garant), Marie PRECECHTELOVA (203 Česká republika), Martina BOJKOVA (203 Česká republika), Martin LOVECEK (203 Česká republika), Radek AMBROZ (203 Česká republika), Arnost MARTINEK (203 Česká republika) a Jiří DOLINA (203 Česká republika, domácí)

Vydání

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2023, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.900 v roce 2022

Kód RIV

RIV/00216224:14110/23:00131200

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5507/bp.2023.019

UT WoS

000996217700001

Klíčová slova anglicky

pancreatic pain; painless form of pancreatitis; diabetes mellitus; pancreatic calcifications; exocrine insufficiency

Štítky

14110213, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 7. 2023 09:25, Mgr. Tereza Miškechová

Anotace

V originále

Background. The painless form of chronic pancreatitis is one of the rarer forms of the disease. While 80% to 90% of all chronic pancreatitis cases have abdominal pain as their clinical symptom, a smaller proportion of persons with chronic pancreatitis do not report typical pain. This form of the disease is often associated with exocrine and endocrine pancreatic insufficiency and weight loss, but the absence of pain symptoms may initially lead to misdiagnosis. Methods. In a cohort of 257 people with chronic pancreatitis, the painless form was diagnosed in 30 individuals (11.6%), with an average age of 56 years and a predominance of men (71.4%). Thirty-eight percent were non-smokers and 47.6% of patients smoked up to 10 cigarettes per day. Alcohol intake of less than 40 g per day was reported by 61.9% of subjects. A quarter were moderately overweight, with a mean BMI of 26.5. Newly diagnosed diabetes mellitus had 25.7% of the subjects.Results. A frequent finding was the demonstration of morphological changes, with calcifications found in 85,7% and dilatation of the pancreatic duct greater than 6.0 mm in 66%. A surprising finding was the presence of metabolic syndrome in 42.8% and the most frequent finding was the demonstration of decreased external pancreatic secretion (90%).Conclusion. Painless chronic pancreatitis is usually treated conservatively. We demonstrate a subset of 28 patients with painless chronic pancreatitis treated surgically. Most frequent indications were benign stenosis of the intrapancreatic bile duct and stenosis of the pancreatic duct. Although approximately 1 in 10 people with chronic pancreatitis present with a painless form of it, so that the form of the disease is described as rare, this does not change the fact that management of these people is still not optimal.

Citovat

DITE, Petr, Marie PRECECHTELOVA, Martina BOJKOVA, Martin LOVECEK, Radek AMBROZ, Arnost MARTINEK a Jiří DOLINA. Painless form of chronic pancreatitis-multicentre study. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2023, roč. 167, č. 2, s. 157-161. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2023.019.

@article{2296988,
   author = {Dite, Petr and Precechtelova, Marie and Bojkova, Martina and Lovecek, Martin and Ambroz, Radek and Martinek, Arnost and Dolina, Jiří},
   article_location = {Olomouc},
   article_number = {2},
   doi = {http://dx.doi.org/10.5507/bp.2023.019},
   keywords = {pancreatic pain; painless form of pancreatitis; diabetes mellitus; pancreatic calcifications; exocrine insufficiency},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers, Olomouc: Palacky University},
   title = {Painless form of chronic pancreatitis-multicentre study},
   url = {https://biomed.papers.upol.cz/artkey/bio-202302-0009_painless-form-of-chronic-pancreatitis-multicentre-study.php},
   volume = {167},
   year = {2023}
}

TY  - JOUR
ID  - 2296988
AU  - Dite, Petr - Precechtelova, Marie - Bojkova, Martina - Lovecek, Martin - Ambroz, Radek - Martinek, Arnost - Dolina, Jiří
PY  - 2023
TI  - Painless form of chronic pancreatitis-multicentre study
JF  - Biomedical Papers, Olomouc: Palacky University
VL  - 167
IS  - 2
SP  - 157-161
EP  - 157-161
PB  - Palacky University
SN  - 12138118
KW  - pancreatic pain
KW  - painless form of pancreatitis
KW  - diabetes mellitus
KW  - pancreatic calcifications
KW  - exocrine insufficiency
UR  - https://biomed.papers.upol.cz/artkey/bio-202302-0009_painless-form-of-chronic-pancreatitis-multicentre-study.php
N2  - Background. The painless form of chronic pancreatitis is one of the rarer forms of the disease. While 80% to 90% of all chronic pancreatitis cases have abdominal pain as their clinical symptom, a smaller proportion of persons with chronic pancreatitis do not report typical pain. This form of the disease is often associated with exocrine and endocrine pancreatic insufficiency and weight loss, but the absence of pain symptoms may initially lead to misdiagnosis. Methods. In a cohort of 257 people with chronic pancreatitis, the painless form was diagnosed in 30 individuals (11.6%), with an average age of 56 years and a predominance of men (71.4%). Thirty-eight percent were non-smokers and 47.6% of patients smoked up to 10 cigarettes per day. Alcohol intake of less than 40 g per day was reported by 61.9% of subjects. A quarter were moderately overweight, with a mean BMI of 26.5. Newly diagnosed diabetes mellitus had 25.7% of the subjects.Results. A frequent finding was the demonstration of morphological changes, with calcifications found in 85,7% and dilatation of the pancreatic duct greater than 6.0 mm in 66%. A surprising finding was the presence of metabolic syndrome in 42.8% and the most frequent finding was the demonstration of decreased external pancreatic secretion (90%).Conclusion. Painless chronic pancreatitis is usually treated conservatively. We demonstrate a subset of 28 patients with painless chronic pancreatitis treated surgically. Most frequent indications were benign stenosis of the intrapancreatic bile duct and stenosis of the pancreatic duct. Although approximately 1 in 10 people with chronic pancreatitis present with a painless form of it, so that the form of the disease is described as rare, this does not change the fact that management of these people is still not optimal.
ER  -

DITE, Petr, Marie PRECECHTELOVA, Martina BOJKOVA, Martin LOVECEK, Radek AMBROZ, Arnost MARTINEK a Jiří DOLINA. Painless form of chronic pancreatitis-multicentre study. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2023, roč.~167, č.~2, s.~157-161. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2023.019.

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