The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer
CAMPA, D.; M. GENTILUOMO; A. STEIN; M. N. AOKI; M. OLIVERIUS et al.
The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer
Autoři
CAMPA, D.; M. GENTILUOMO; A. STEIN; M. N. AOKI; M. OLIVERIUS; L. VODIČKOVÁ; K. JAMROZIAK; G. THEODOROPOULOS; C. PASQUALI; W. GREENHALF; P. G. ARCIDIACONO; F. UZUNOGLU; R. PEZZILLI; C. LUCHINI; M. PUZZONO; M. LOOS; M. GIACCHERINI; V. KATZKE; A. MAMBRINI; E. KIUDELIENE; K. E. FEDERICO; J. JOHANSEN; T. HUSSEIN; B. MOHELNIKOVA-DUCHONOVA; C. H. J. VAN EIJCK; H. BRENNER; R. FARINELLA; J. S. PÉREZ; M. LOVECEK; M. W. BÜCHLER; Viktor HLAVAC; J. R. IZBICKI; T. HACKERT; R. CHAMMAS; A. ZERBI; R. LAWLOR; A. FELICI; M. GÖTZ; G. CAPURSO; L. GINOCCHI; M. GAZOULI; J. KUPCINSKAS; G. M. CAVESTRO; Pavel VODICKA; S. MOZ; J. P. NEOPTOLEMOS; Lumír KUNOVSKÝ; S. E. BOJESEN; S. CARRARA; D. GIOFFREDA; E. MORKUNAS; O. ABIAN; S. BUNDUC; D. BASSO; U. BOGGI; B. WLODARCZYK; A. SZENTESI; G. VANELLA; I. CHEN; M. F. BIJLSMA; V. KIUDELIS; S. LANDI; B. SCHÖTTKER; C. CORRADI; N. GIESE; R. KAAKS; G. PEDUZZI; P. HEGYI; L. MORELLI; N. FURBETTA; Pavel SOUCEK; A. LATIANO; R. TALAR-WOJNAROWSKA; S. C. LINDGAARD; F. DIJK; A. C. MILANETTO; F. TAVANO; Klara CERVENA; B. ERŐSS; S. G. TESTONI; J. H. E. VERHAGEN-OLDENAMPSEN; E. MAŁECKA-WOJCIESKO; E. COSTELLO; R. SALVIA; E. MAIELLO; S. ERMINI; C. SPERTI; B. HOLLECZEK; F. PERRI; J. SKIECEVICIENE; L. ARCHIBUGI; M. LUCCHESI; C. RIZZATO a F. CANZIAN
Vydání
Critical reviews in oncology/hematology, NEW YORK, ELSEVIER SCIENCE INC, 2023, 1040-8428
Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.
Návaznosti
LX22NPO5102, projekt VaV
Název: Národní ústav pro výzkum rakoviny (Akronym: NÚVR)
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro výzkum rakoviny, 5.1 EXCELES
CAMPA, D.; M. GENTILUOMO; A. STEIN; M. N. AOKI; M. OLIVERIUS; L. VODIČKOVÁ; K. JAMROZIAK; G. THEODOROPOULOS; C. PASQUALI; W. GREENHALF; P. G. ARCIDIACONO; F. UZUNOGLU; R. PEZZILLI; C. LUCHINI; M. PUZZONO; M. LOOS; M. GIACCHERINI; V. KATZKE; A. MAMBRINI; E. KIUDELIENE; K. E. FEDERICO; J. JOHANSEN; T. HUSSEIN; B. MOHELNIKOVA-DUCHONOVA; C. H. J. VAN EIJCK; H. BRENNER; R. FARINELLA; J. S. PÉREZ; M. LOVECEK; M. W. BÜCHLER; Viktor HLAVAC; J. R. IZBICKI; T. HACKERT; R. CHAMMAS; A. ZERBI; R. LAWLOR; A. FELICI; M. GÖTZ; G. CAPURSO; L. GINOCCHI; M. GAZOULI; J. KUPCINSKAS; G. M. CAVESTRO; Pavel VODICKA; S. MOZ; J. P. NEOPTOLEMOS; Lumír KUNOVSKÝ; S. E. BOJESEN; S. CARRARA; D. GIOFFREDA; E. MORKUNAS; O. ABIAN; S. BUNDUC; D. BASSO; U. BOGGI; B. WLODARCZYK; A. SZENTESI; G. VANELLA; I. CHEN; M. F. BIJLSMA; V. KIUDELIS; S. LANDI; B. SCHÖTTKER; C. CORRADI; N. GIESE; R. KAAKS; G. PEDUZZI; P. HEGYI; L. MORELLI; N. FURBETTA; Pavel SOUCEK; A. LATIANO; R. TALAR-WOJNAROWSKA; S. C. LINDGAARD; F. DIJK; A. C. MILANETTO; F. TAVANO; Klara CERVENA; B. ERŐSS; S. G. TESTONI; J. H. E. VERHAGEN-OLDENAMPSEN; E. MAŁECKA-WOJCIESKO; E. COSTELLO; R. SALVIA; E. MAIELLO; S. ERMINI; C. SPERTI; B. HOLLECZEK; F. PERRI; J. SKIECEVICIENE; L. ARCHIBUGI; M. LUCCHESI; C. RIZZATO a F. CANZIAN. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer. Critical reviews in oncology/hematology. NEW YORK: ELSEVIER SCIENCE INC, 2023, roč. 186, June 2023, s. 1-13. ISSN 1040-8428. Dostupné z: https://doi.org/10.1016/j.critrevonc.2023.104020.
@article{2297219, author = {Campa, D. and Gentiluomo, M. and Stein, A. and Aoki, M. N. and Oliverius, M. and Vodičková, L. and Jamroziak, K. and Theodoropoulos, G. and Pasquali, C. and Greenhalf, W. and Arcidiacono, P. G. and Uzunoglu, F. and Pezzilli, R. and Luchini, C. and Puzzono, M. and Loos, M. and Giaccherini, M. and Katzke, V. and Mambrini, A. and Kiudeliene, E. and Federico, K. E. and Johansen, J. and Hussein, T. and MohelnikovaandDuchonova, B. and van Eijck, C. H. J. and Brenner, H. and Farinella, R. and Pérez, J. S. and Lovecek, M. and Büchler, M. W. and Hlavac, Viktor and Izbicki, J. R. and Hackert, T. and Chammas, R. and Zerbi, A. and Lawlor, R. and Felici, A. and Götz, M. and Capurso, G. and Ginocchi, L. and Gazouli, M. and Kupcinskas, J. and Cavestro, G. M. and Vodicka, Pavel and Moz, S. and Neoptolemos, J. P. and Kunovský, Lumír and Bojesen, S. E. and Carrara, S. and Gioffreda, D. and Morkunas, E. and Abian, O. and Bunduc, S. and Basso, D. and Boggi, U. and Wlodarczyk, B. and Szentesi, A. and Vanella, G. and Chen, I. and Bijlsma, M. F. and Kiudelis, V. and Landi, S. and Schöttker, B. and Corradi, C. and Giese, N. and Kaaks, R. and Peduzzi, G. and Hegyi, P. and Morelli, L. and Furbetta, N. and Soucek, Pavel and Latiano, A. and TalarandWojnarowska, R. and Lindgaard, S. C. and Dijk, F. and Milanetto, A. C. and Tavano, F. and Cervena, Klara and Erőss, B. and Testoni, S. G. and VerhagenandOldenampsen, J. H. E. and MałeckaandWojciesko, E. and Costello, E. and Salvia, R. and Maiello, E. and Ermini, S. and Sperti, C. and Holleczek, B. and Perri, F. and Skieceviciene, J. and Archibugi, L. and Lucchesi, M. and Rizzato, C. and Canzian, F.}, article_location = {NEW YORK}, article_number = {June 2023}, doi = {https://doi.org/10.1016/j.critrevonc.2023.104020}, keywords = {Pancreatic cancer; Pancreatic ductal adenocarcinoma; Pancreatic neuroendocrine tumors; Intraductal papillary mucinous neoplasms; Chronic pancreatitis; Genetic epidemiology; Consortium}, language = {eng}, issn = {1040-8428}, journal = {Critical reviews in oncology/hematology}, title = {The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer}, url = {https://www.sciencedirect.com/science/article/pii/S1040842823001087?via%3Dihub}, volume = {186}, year = {2023} }
TY - JOUR ID - 2297219 AU - Campa, D. - Gentiluomo, M. - Stein, A. - Aoki, M. N. - Oliverius, M. - Vodičková, L. - Jamroziak, K. - Theodoropoulos, G. - Pasquali, C. - Greenhalf, W. - Arcidiacono, P. G. - Uzunoglu, F. - Pezzilli, R. - Luchini, C. - Puzzono, M. - Loos, M. - Giaccherini, M. - Katzke, V. - Mambrini, A. - Kiudeliene, E. - Federico, K. E. - Johansen, J. - Hussein, T. - Mohelnikova-Duchonova, B. - van Eijck, C. H. J. - Brenner, H. - Farinella, R. - Pérez, J. S. - Lovecek, M. - Büchler, M. W. - Hlavac, Viktor - Izbicki, J. R. - Hackert, T. - Chammas, R. - Zerbi, A. - Lawlor, R. - Felici, A. - Götz, M. - Capurso, G. - Ginocchi, L. - Gazouli, M. - Kupcinskas, J. - Cavestro, G. M. - Vodicka, Pavel - Moz, S. - Neoptolemos, J. P. - Kunovský, Lumír - Bojesen, S. E. - Carrara, S. - Gioffreda, D. - Morkunas, E. - Abian, O. - Bunduc, S. - Basso, D. - Boggi, U. - Wlodarczyk, B. - Szentesi, A. - Vanella, G. - Chen, I. - Bijlsma, M. F. - Kiudelis, V. - Landi, S. - Schöttker, B. - Corradi, C. - Giese, N. - Kaaks, R. - Peduzzi, G. - Hegyi, P. - Morelli, L. - Furbetta, N. - Soucek, Pavel - Latiano, A. - Talar-Wojnarowska, R. - Lindgaard, S. C. - Dijk, F. - Milanetto, A. C. - Tavano, F. - Cervena, Klara - Erőss, B. - Testoni, S. G. - Verhagen-Oldenampsen, J. H. E. - Małecka-Wojciesko, E. - Costello, E. - Salvia, R. - Maiello, E. - Ermini, S. - Sperti, C. - Holleczek, B. - Perri, F. - Skieceviciene, J. - Archibugi, L. - Lucchesi, M. - Rizzato, C. - Canzian, F. PY - 2023 TI - The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer JF - Critical reviews in oncology/hematology VL - 186 IS - June 2023 SP - 1-13 EP - 1-13 PB - ELSEVIER SCIENCE INC SN - 10408428 KW - Pancreatic cancer KW - Pancreatic ductal adenocarcinoma KW - Pancreatic neuroendocrine tumors KW - Intraductal papillary mucinous neoplasms KW - Chronic pancreatitis KW - Genetic epidemiology KW - Consortium UR - https://www.sciencedirect.com/science/article/pii/S1040842823001087?via%3Dihub N2 - Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies. ER -
CAMPA, D.; M. GENTILUOMO; A. STEIN; M. N. AOKI; M. OLIVERIUS; L. VODIČKOVÁ; K. JAMROZIAK; G. THEODOROPOULOS; C. PASQUALI; W. GREENHALF; P. G. ARCIDIACONO; F. UZUNOGLU; R. PEZZILLI; C. LUCHINI; M. PUZZONO; M. LOOS; M. GIACCHERINI; V. KATZKE; A. MAMBRINI; E. KIUDELIENE; K. E. FEDERICO; J. JOHANSEN; T. HUSSEIN; B. MOHELNIKOVA-DUCHONOVA; C. H. J. VAN EIJCK; H. BRENNER; R. FARINELLA; J. S. PÉREZ; M. LOVECEK; M. W. BÜCHLER; Viktor HLAVAC; J. R. IZBICKI; T. HACKERT; R. CHAMMAS; A. ZERBI; R. LAWLOR; A. FELICI; M. GÖTZ; G. CAPURSO; L. GINOCCHI; M. GAZOULI; J. KUPCINSKAS; G. M. CAVESTRO; Pavel VODICKA; S. MOZ; J. P. NEOPTOLEMOS; Lumír KUNOVSKÝ; S. E. BOJESEN; S. CARRARA; D. GIOFFREDA; E. MORKUNAS; O. ABIAN; S. BUNDUC; D. BASSO; U. BOGGI; B. WLODARCZYK; A. SZENTESI; G. VANELLA; I. CHEN; M. F. BIJLSMA; V. KIUDELIS; S. LANDI; B. SCHÖTTKER; C. CORRADI; N. GIESE; R. KAAKS; G. PEDUZZI; P. HEGYI; L. MORELLI; N. FURBETTA; Pavel SOUCEK; A. LATIANO; R. TALAR-WOJNAROWSKA; S. C. LINDGAARD; F. DIJK; A. C. MILANETTO; F. TAVANO; Klara CERVENA; B. ER$\backslash$H OSS; S. G. TESTONI; J. H. E. VERHAGEN-OLDENAMPSEN; E. MAŁECKA-WOJCIESKO; E. COSTELLO; R. SALVIA; E. MAIELLO; S. ERMINI; C. SPERTI; B. HOLLECZEK; F. PERRI; J. SKIECEVICIENE; L. ARCHIBUGI; M. LUCCHESI; C. RIZZATO a F. CANZIAN. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer. \textit{Critical reviews in oncology/hematology}. NEW YORK: ELSEVIER SCIENCE INC, 2023, roč.~186, June 2023, s.~1-13. ISSN~1040-8428. Dostupné z: https://doi.org/10.1016/j.critrevonc.2023.104020.
