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@article{2297961,
author = {Žalud, Michal and Prysiazhnyi, Vadym and Bednařík, Antonín and Preisler, Jan},
article_number = {7},
doi = {http://dx.doi.org/10.1021/jasms.3c00137},
keywords = {Diagnostic imaging; Ions; Lasers; Mass spectrometry; Metal nanoparticles},
language = {eng},
issn = {1044-0305},
journal = {Journal of the American Society for Mass Spectrometry},
title = {Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry},
url = {https://pubs.acs.org/doi/10.1021/jasms.3c00137},
volume = {34},
year = {2023}
}
TY - JOUR
ID - 2297961
AU - Žalud, Michal - Prysiazhnyi, Vadym - Bednařík, Antonín - Preisler, Jan
PY - 2023
TI - Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
VL - 34
IS - 7
SP - 1459-1466
EP - 1459-1466
PB - American Chemical Society
SN - 10440305
KW - Diagnostic imaging
KW - Ions
KW - Lasers
KW - Mass spectrometry
KW - Metal nanoparticles
UR - https://pubs.acs.org/doi/10.1021/jasms.3c00137
N2 - The detection of a single entity (molecule, cell, particle, etc.) was always a challenging subject. Here we demonstrate the detection of single Ag nanoparticles (NPs) using subatmospheric pressure laser desorption/ionization mass spectrometry (LDI MS). The sample preparation, measurement conditions, generated ions, and limiting experimental factors are discussed here. We detected from 84 to 95% of the deposited 80 nm Ag NPs. The presented LDI MS platform is an alternative to laser ablation inductively coupled plasma mass spectrometry for imaging distribution of individual NPs across the sample surface and has a great potential for multiplexed mapping of low-abundance biomarkers in tissues.
ER -
ŽALUD, Michal, Vadym PRYSIAZHNYI, Antonín BEDNAŘÍK and Jan PREISLER. Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry. \textit{Journal of the American Society for Mass Spectrometry}. American Chemical Society, 2023, vol.~34, No~7, p.~1459-1466. ISSN~1044-0305. Available from: https://dx.doi.org/10.1021/jasms.3c00137.
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