Detection of Single Ag Nanoparticles Using Laser
Desorption/Ionization Mass Spectrometry

J 2023

Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry

ŽALUD, Michal, Vadym PRYSIAZHNYI, Antonín BEDNAŘÍK and Jan PREISLER

Basic information

Original name

Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry

Authors

ŽALUD, Michal (203 Czech Republic, belonging to the institution), Vadym PRYSIAZHNYI (804 Ukraine, belonging to the institution), Antonín BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Jan PREISLER (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of the American Society for Mass Spectrometry, American Chemical Society, 2023, 1044-0305

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10406 Analytical chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.200 in 2022

RIV identification code

RIV/00216224:14310/23:00131251

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1021/jasms.3c00137

UT WoS

001006215900001

Keywords in English

Diagnostic imaging; Ions; Lasers; Mass spectrometry; Metal nanoparticles

Abstract

V originále

The detection of a single entity (molecule, cell, particle, etc.) was always a challenging subject. Here we demonstrate the detection of single Ag nanoparticles (NPs) using subatmospheric pressure laser desorption/ionization mass spectrometry (LDI MS). The sample preparation, measurement conditions, generated ions, and limiting experimental factors are discussed here. We detected from 84 to 95% of the deposited 80 nm Ag NPs. The presented LDI MS platform is an alternative to laser ablation inductively coupled plasma mass spectrometry for imaging distribution of individual NPs across the sample surface and has a great potential for multiplexed mapping of low-abundance biomarkers in tissues.

Links

GA21-12262S, research and development project

Name: Nanočásticové sondy pro zobrazovací hmotnostní spektrometrii

Investor: Czech Science Foundation

MUNI/A/1421/2022, interní kód MU

Name: Vývoj metod a instrumentace pro analýzu biologicky významných látek 2023

Investor: Masaryk University

90127, large research infrastructures

Name: CIISB II

90242, large research infrastructures

Name: CIISB III

Citovat

ŽALUD, Michal, Vadym PRYSIAZHNYI, Antonín BEDNAŘÍK and Jan PREISLER. Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry. Journal of the American Society for Mass Spectrometry. American Chemical Society, 2023, vol. 34, No 7, p. 1459-1466. ISSN 1044-0305. Available from: https://dx.doi.org/10.1021/jasms.3c00137.

@article{2297961,
   author = {Žalud, Michal and Prysiazhnyi, Vadym and Bednařík, Antonín and Preisler, Jan},
   article_number = {7},
   doi = {http://dx.doi.org/10.1021/jasms.3c00137},
   keywords = {Diagnostic imaging; Ions; Lasers; Mass spectrometry; Metal nanoparticles},
   language = {eng},
   issn = {1044-0305},
   journal = {Journal of the American Society for Mass Spectrometry},
   title = {Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry},
   url = {https://pubs.acs.org/doi/10.1021/jasms.3c00137},
   volume = {34},
   year = {2023}
}

TY  - JOUR
ID  - 2297961
AU  - Žalud, Michal - Prysiazhnyi, Vadym - Bednařík, Antonín - Preisler, Jan
PY  - 2023
TI  - Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry
JF  - Journal of the American Society for Mass Spectrometry
VL  - 34
IS  - 7
SP  - 1459-1466
EP  - 1459-1466
PB  - American Chemical Society
SN  - 10440305
KW  - Diagnostic imaging
KW  - Ions
KW  - Lasers
KW  - Mass spectrometry
KW  - Metal nanoparticles
UR  - https://pubs.acs.org/doi/10.1021/jasms.3c00137
N2  - The detection of a single entity (molecule, cell, particle, etc.) was always a challenging subject. Here we demonstrate the detection of single Ag nanoparticles (NPs) using subatmospheric pressure laser desorption/ionization mass spectrometry (LDI MS). The sample preparation, measurement conditions, generated ions, and limiting experimental factors are discussed here. We detected from 84 to 95% of the deposited 80 nm Ag NPs. The presented LDI MS platform is an alternative to laser ablation inductively coupled plasma mass spectrometry for imaging distribution of individual NPs across the sample surface and has a great potential for multiplexed mapping of low-abundance biomarkers in tissues.
ER  -

ŽALUD, Michal, Vadym PRYSIAZHNYI, Antonín BEDNAŘÍK and Jan PREISLER. Detection of Single Ag Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry. \textit{Journal of the American Society for Mass Spectrometry}. American Chemical Society, 2023, vol.~34, No~7, p.~1459-1466. ISSN~1044-0305. Available from: https://dx.doi.org/10.1021/jasms.3c00137.

Detailed Information on Publication Record