G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl
Probe Revealed by Solution NMR and Time-Resolved Infrared
Studies

J 2023

G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies

PETERKOVÁ, Kateřina, Mark STITCH, Rayhaan Z. BOOTA, Paul A. SCATTERGOOD, Paul I. P. ELLIOTT et. al.

Základní údaje

Originální název

G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies

Autoři

PETERKOVÁ, Kateřina (203 Česká republika, domácí), Mark STITCH, Rayhaan Z. BOOTA, Paul A. SCATTERGOOD, Paul I. P. ELLIOTT, Michael TOWRIE, Peter PODBEVŠEK, Janez PLAVEC (garant) a Susan J. QUINN

Vydání

Chemistry - A European Journal, Wiley, 2023, 0947-6539

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300 v roce 2022

Kód RIV

RIV/00216224:14310/23:00131306

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/chem.202203250

UT WoS

000912658800001

Klíčová slova anglicky

G-quadruplex; luminescent enhancement; NMR; osmium polypyridyl; spectroscopy; TRIR

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 7. 2023 12:16, Mgr. Marie Šípková, DiS.

Anotace

V originále

G-quadruplexes are emerging targets in cancer research and understanding how diagnostic probes bind to DNA G-quadruplexes in solution is critical to the development of new molecular tools. In this study the binding of an enantiopure NIR emitting [Os(TAP)(2)(dppz)](2+) complex to different G-quadruplex structures formed by human telomer (hTel) and cMYC sequences in solution is reported. The combination of NMR and time-resolved infrared spectroscopic techniques reveals the sensitivity of the emission response to subtle changes in the binding environment of the complex. Similar behaviour is also observed for the related complex [Os(TAP)(2)(dppp2)](2+) upon quadruplex binding.

Citovat

PETERKOVÁ, Kateřina, Mark STITCH, Rayhaan Z. BOOTA, Paul A. SCATTERGOOD, Paul I. P. ELLIOTT, Michael TOWRIE, Peter PODBEVŠEK, Janez PLAVEC a Susan J. QUINN. G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies. Chemistry - A European Journal. Wiley, 2023, roč. 29, č. 11, s. 1-7. ISSN 0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.202203250.

@article{2299136,
   author = {Peterková, Kateřina and Stitch, Mark and Boota, Rayhaan Z. and Scattergood, Paul A. and Elliott, Paul I. P. and Towrie, Michael and Podbevšek, Peter and Plavec, Janez and Quinn, Susan J.},
   article_number = {11},
   doi = {http://dx.doi.org/10.1002/chem.202203250},
   keywords = {G-quadruplex; luminescent enhancement; NMR; osmium polypyridyl; spectroscopy; TRIR},
   language = {eng},
   issn = {0947-6539},
   journal = {Chemistry - A European Journal},
   title = {G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies},
   url = {https://doi.org/10.1002/chem.202203250},
   volume = {29},
   year = {2023}
}

TY  - JOUR
ID  - 2299136
AU  - Peterková, Kateřina - Stitch, Mark - Boota, Rayhaan Z. - Scattergood, Paul A. - Elliott, Paul I. P. - Towrie, Michael - Podbevšek, Peter - Plavec, Janez - Quinn, Susan J.
PY  - 2023
TI  - G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies
JF  - Chemistry - A European Journal
VL  - 29
IS  - 11
SP  - 1-7
EP  - 1-7
PB  - Wiley
SN  - 09476539
KW  - G-quadruplex
KW  - luminescent enhancement
KW  - NMR
KW  - osmium polypyridyl
KW  - spectroscopy
KW  - TRIR
UR  - https://doi.org/10.1002/chem.202203250
N2  - G-quadruplexes are emerging targets in cancer research and understanding how diagnostic probes bind to DNA G-quadruplexes in solution is critical to the development of new molecular tools. In this study the binding of an enantiopure NIR emitting [Os(TAP)(2)(dppz)](2+) complex to different G-quadruplex structures formed by human telomer (hTel) and cMYC sequences in solution is reported. The combination of NMR and time-resolved infrared spectroscopic techniques reveals the sensitivity of the emission response to subtle changes in the binding environment of the complex. Similar behaviour is also observed for the related complex [Os(TAP)(2)(dppp2)](2+) upon quadruplex binding.
ER  -

PETERKOVÁ, Kateřina, Mark STITCH, Rayhaan Z. BOOTA, Paul A. SCATTERGOOD, Paul I. P. ELLIOTT, Michael TOWRIE, Peter PODBEVŠEK, Janez PLAVEC a Susan J. QUINN. G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies. \textit{Chemistry - A European Journal}. Wiley, 2023, roč.~29, č.~11, s.~1-7. ISSN~0947-6539. Dostupné z: https://dx.doi.org/10.1002/chem.202203250.

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