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@article{2300337,
author = {Kovac, Jan and Slobodnikova, Livia and Trajcikova, Eva and Rendekova, Katarina and Mucaji, Pavel and Sychrová, Alice and Fialova, Silvia Bittner},
article_location = {Basel},
article_number = {1},
doi = {http://dx.doi.org/10.3390/molecules28010158},
keywords = {antimicrobial activity; antibiofilm activity; flavonoids; medicinal plants; natural products; oral infections; oral pathogens; tannins},
language = {eng},
issn = {1420-3049},
journal = {MOLECULES},
title = {Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases-A Review},
url = {https://mdpi-res.com/d_attachment/molecules/molecules-28-00158/article_deploy/molecules-28-00158-v2.pdf?version=1672141957},
volume = {28},
year = {2023}
}
TY - JOUR
ID - 2300337
AU - Kovac, Jan - Slobodnikova, Livia - Trajcikova, Eva - Rendekova, Katarina - Mucaji, Pavel - Sychrová, Alice - Fialova, Silvia Bittner
PY - 2023
TI - Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases-A Review
JF - MOLECULES
VL - 28
IS - 1
SP - 1-21
EP - 1-21
PB - MDPI
SN - 14203049
KW - antimicrobial activity
KW - antibiofilm activity
KW - flavonoids
KW - medicinal plants
KW - natural products
KW - oral infections
KW - oral pathogens
KW - tannins
UR - https://mdpi-res.com/d_attachment/molecules/molecules-28-00158/article_deploy/molecules-28-00158-v2.pdf?version=1672141957
N2 - Medicinal plants are rich sources of valuable molecules with various profitable biological effects, including antimicrobial activity. The advantages of herbal products are their effectiveness, relative safety based on research or extended traditional use, and accessibility without prescription. Extensive and irrational usage of antibiotics since their discovery in 1928 has led to the increasing expiration of their effectiveness due to antibacterial resistance. Now, medical research is facing a big and challenging mission to find effective and safe antimicrobial therapies to replace inactive drugs. Over the years, one of the research fields that remained the most available is the area of natural products: medicinal plants and their metabolites, which could serve as active substances to fight against microbes or be considered as models in drug design. This review presents selected flavonoids (such as apigenin, quercetin, kaempferol, kurarinone, and morin) and tannins (including oligomeric proanthocyanidins, gallotannins, ellagitannins, catechins, and epigallocatechin gallate), but also medicinal plants rich in these compounds as potential therapeutic agents in oral infectious diseases based on traditional usages such as Agrimonia eupatoria L., Hamamelis virginiana L., Matricaria chamomilla L., Vaccinium myrtillus L., Quercus robur L., Rosa gallica L., Rubus idaeus L., or Potentilla erecta (L.). Some of the presented compounds and extracts are already successfully used to maintain oral health, as the main or additive ingredient of toothpastes or mouthwashes. Others are promising for further research or future applications.
ER -
KOVAC, Jan, Livia SLOBODNIKOVA, Eva TRAJCIKOVA, Katarina RENDEKOVA, Pavel MUCAJI, Alice SYCHROVÁ a Silvia Bittner FIALOVA. Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases-A Review. \textit{MOLECULES}. Basel: MDPI, 2023, roč.~28, č.~1, s.~1-21. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules28010158.
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