Detailed Information on Publication Record
2023
Nanodiamonds as artificial proteins for regulation of a cell signalling system
CÍGLER, Petr, Lukáš BÁLEK, Jan HAVLÍK, Pavel KREJČÍ, Lukáš TRANTÍREK et. al.Basic information
Original name
Nanodiamonds as artificial proteins for regulation of a cell signalling system
Authors
CÍGLER, Petr (203 Czech Republic), Lukáš BÁLEK (203 Czech Republic, belonging to the institution), Jan HAVLÍK (203 Czech Republic), Pavel KREJČÍ (203 Czech Republic), Lukáš TRANTÍREK (203 Czech Republic, guarantor, belonging to the institution) and Silvie TRANTÍRKOVÁ (203 Czech Republic, belonging to the institution)
Edition
Number: EP3645018B1, Publisher: European Patent Office, Place of publication: Mnichov, Owner's name: Ústav organické chemie a biochemie AV ČR; Masarykova univerzita; Fakultní nemocnice u sv. Anny v Brně; 2023
Other information
Language
English
Type of outcome
Patent
Field of Study
30400 3.4 Medical biotechnology
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14740/23:00131427
Organization unit
Central European Institute of Technology
Keywords in English
nanosized diamond crystals;nanodiamonds;fibroblast grow factors;extracellular signalling molecules;serum proteins
Tags
Změněno: 3/4/2024 15:15, Mgr. Eva Dubská
Abstract
V originále
Here, we show that nanosized diamond crystals (nanodiamonds, NDs) without any synthetically installed (bio)organic interface enable the specific and efficient targeting of the family of extracellular signalling molecules known as fibroblast growth factors (FGFs). We found that at certain conditions the ND strongly associate with multiple FGF ligands present at sub-nanomolar concentrations and effectively neutralize the effects of FGF signalling in cells without interfering with other growth factor systems and serum proteins unrelated to FGFs.
Links
| GA17-12075S, research and development project |
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| LQ1601, research and development project |
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