Cortisol in deciduous tooth tissues: A potential metric for
assessing stress exposure in archaeological and living
populations

J 2023

Cortisol in deciduous tooth tissues: A potential metric for assessing stress exposure in archaeological and living populations

QUADE, Leslie, Miroslav KRÁLÍK, Petra BENCÚROVÁ a Erin C. DUNN

Základní údaje

Originální název

Cortisol in deciduous tooth tissues: A potential metric for assessing stress exposure in archaeological and living populations

Autoři

QUADE, Leslie (840 Spojené státy, garant, domácí), Miroslav KRÁLÍK (203 Česká republika, domácí), Petra BENCÚROVÁ (703 Slovensko, domácí) a Erin C. DUNN (840 Spojené státy)

Vydání

International Journal of Paleopathology, Elsevier, 2023, 1879-9817

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10700 1.7 Other natural sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

oficiální stránka časopisu

Impakt faktor

Impact factor: 1.200 v roce 2022

Kód RIV

RIV/00216224:14310/23:00131508

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.ijpp.2023.08.001

UT WoS

001067211900001

Klíčová slova anglicky

Glucocorticoid Hormones; Dentine; Enamel; Circumpulpal Dentine; Fetus; Dentition

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 3. 2024 10:37, Mgr. Eva Dubská

Anotace

V originále

Objective. Cortisol is a glucocorticoid hormone produced by the hypothalamic-pituitary-adrenal axis that is regularly assessed in modern human and non-human populations in saliva, blood, and hair as a measure of stress exposure and stress reactivity. While recent research has detected cortisol concentrations in modern and archaeological permanent dental tissues, the present study assessed human primary (deciduous) teeth for cortisol concentrations. Materials and Methods. Fifty-one dentine and enamel samples from nine modern and 10 archaeological deciduous teeth were analyzed for cortisol concentrations via enzyme-linked immunosorbent assay (ELISA). Results. Detectable concentrations of cortisol were identified in 15 (of 32) dentine and 8 (of 19) enamel samples coming from modern and archaeological deciduous teeth. Conclusions. This study is the first known analysis of cortisol from deciduous dental tissues, demonstrating the potential to identify measurable concentrations. Significance. The ability to analyze deciduous teeth is integral to developing dental cortisol methods with multiple potential future applications, including research on the biological embedding of stress in the skeleton. This study marks a key step in a larger research program to study stress in primary dentition from living and archaeological populations. Limitations. Multiple samples generated cortisol values that were not detectable with ELISA. Minimum quantities of tissue may be required to generate detectable levels of cortisol. Suggestions for Further Research. Future research should include larger sample sizes and consideration of intrinsic biological and extrinsic preservation factors on dental cortisol. Further method validation and alternative methods for assessing dental cortisol are needed.

Návaznosti

EF18_053/0016952, projekt VaV

Název: Postdoc2MUNI

Citovat

QUADE, Leslie, Miroslav KRÁLÍK, Petra BENCÚROVÁ a Erin C. DUNN. Cortisol in deciduous tooth tissues: A potential metric for assessing stress exposure in archaeological and living populations. International Journal of Paleopathology. Elsevier, 2023, roč. 43, December 2023, s. 1-6. ISSN 1879-9817. Dostupné z: https://dx.doi.org/10.1016/j.ijpp.2023.08.001.

@article{2304217,
   author = {Quade, Leslie and Králík, Miroslav and Bencúrová, Petra and Dunn, Erin C.},
   article_number = {December 2023},
   doi = {http://dx.doi.org/10.1016/j.ijpp.2023.08.001},
   keywords = {Glucocorticoid Hormones; Dentine; Enamel; Circumpulpal Dentine; Fetus; Dentition},
   language = {eng},
   issn = {1879-9817},
   journal = {International Journal of Paleopathology},
   title = {Cortisol in deciduous tooth tissues: A potential metric for assessing stress exposure in archaeological and living populations},
   url = {https://www.sciencedirect.com/science/article/pii/S1879981723000414},
   volume = {43},
   year = {2023}
}

TY  - JOUR
ID  - 2304217
AU  - Quade, Leslie - Králík, Miroslav - Bencúrová, Petra - Dunn, Erin C.
PY  - 2023
TI  - Cortisol in deciduous tooth tissues: A potential metric for assessing stress exposure in archaeological and living populations
JF  - International Journal of Paleopathology
VL  - 43
IS  - December 2023
SP  - 1-6
EP  - 1-6
PB  - Elsevier
SN  - 18799817
KW  - Glucocorticoid Hormones
KW  - Dentine
KW  - Enamel
KW  - Circumpulpal Dentine
KW  - Fetus
KW  - Dentition
UR  - https://www.sciencedirect.com/science/article/pii/S1879981723000414
N2  - Objective. Cortisol is a glucocorticoid hormone produced by the hypothalamic-pituitary-adrenal axis that is regularly assessed in modern human and non-human populations in saliva, blood, and hair as a measure of stress exposure and stress reactivity. While recent research has detected cortisol concentrations in modern and archaeological permanent dental tissues, the present study assessed human primary (deciduous) teeth for cortisol concentrations. Materials and Methods. Fifty-one dentine and enamel samples from nine modern and 10 archaeological deciduous teeth were analyzed for cortisol concentrations via enzyme-linked immunosorbent assay (ELISA). Results. Detectable concentrations of cortisol were identified in 15 (of 32) dentine and 8 (of 19) enamel samples coming from modern and archaeological deciduous teeth. Conclusions. This study is the first known analysis of cortisol from deciduous dental tissues, demonstrating the potential to identify measurable concentrations. Significance. The ability to analyze deciduous teeth is integral to developing dental cortisol methods with multiple potential future applications, including research on the biological embedding of stress in the skeleton. This study marks a key step in a larger research program to study stress in primary dentition from living and archaeological populations. Limitations. Multiple samples generated cortisol values that were not detectable with ELISA. Minimum quantities of tissue may be required to generate detectable levels of cortisol. Suggestions for Further Research. Future research should include larger sample sizes and consideration of intrinsic biological and extrinsic preservation factors on dental cortisol. Further method validation and alternative methods for assessing dental cortisol are needed.
ER  -

QUADE, Leslie, Miroslav KRÁLÍK, Petra BENCÚROVÁ a Erin C. DUNN. Cortisol in deciduous tooth tissues: A potential metric for assessing stress exposure in archaeological and living populations. \textit{International Journal of Paleopathology}. Elsevier, 2023, roč.~43, December 2023, s.~1-6. ISSN~1879-9817. Dostupné z: https://dx.doi.org/10.1016/j.ijpp.2023.08.001.

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