Exploring the Association between Schizophrenia and
Cardiovascular Diseases: Insights into the Role of Sigma 1
Receptor

J 2023

Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor

RAFČÍKOVÁ, Julie, Marie NOVÁKOVÁ a Tibor STRAČINA

Základní údaje

Originální název

Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor

Autoři

RAFČÍKOVÁ, Julie (203 Česká republika, domácí), Marie NOVÁKOVÁ (203 Česká republika, domácí) a Tibor STRAČINA (703 Slovensko, domácí)

Vydání

Physiological research, Praha, Fyziologický ústav AV ČR, 2023, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.100 v roce 2022

Kód RIV

RIV/00216224:14110/23:00131540

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.33549/physiolres.935099

UT WoS

001049127500003

Klíčová slova anglicky

Schizophrenia; Cardiovascular diseases; Sigma 1 receptor

Štítky

14110515, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 8. 2023 13:38, Mgr. Tereza Miškechová

Anotace

V originále

Contemporary society is characterized by rapid changes. Various epidemiological, political and economic crises represent a burden to mental health of nowadays population, which may at least partially explain the increasing incidence of mental disorders, including schizophrenia. Schizophrenia is associated with premature mortality by at least 13-15 years. The leading cause of premature mortality in schizophrenia patients is high incidence of cardiovascular diseases. The specific-cause mortality risk for cardiovascular diseases in schizophrenia patients is more than twice higher as compared to the general population. Several factors are discussed as the factor of cardiovascular diseases development. Intensive efforts to identify possible link between schizophrenia and cardiovascular diseases are made. It seems that sigma 1 receptor may represent such link. By modulation of the activity of several neurotransmitter systems, including dopamine, glutamate, and GABA, sigma 1 receptor might play a role in pathophysiology of schizophrenia. Moreover, significant roles of sigma 1 receptor in cardiovascular system have been repeatedly reported. The detailed role of sigma 1 receptor in both schizophrenia and cardiovascular disorders development however remains unclear. The article presents an overview of current knowledge about the association between schizophrenia and cardiovascular diseases and proposes possible explanations with special emphasis on the role of the sigma 1 receptor.

Návaznosti

MUNI/A/1343/2022, interní kód MU

Název: Zátěže kardiovaskulárního systému od A po Z

Investor: Masarykova univerzita, Zátěže kardiovaskulárního systému od A po Z

Citovat

RAFČÍKOVÁ, Julie, Marie NOVÁKOVÁ a Tibor STRAČINA. Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor. Physiological research. Praha: Fyziologický ústav AV ČR, 2023, roč. 72, Supplement 2, s. "S113"-"S126", 14 s. ISSN 0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.935099.

@article{2305120,
   author = {Rafčíková, Julie and Nováková, Marie and Stračina, Tibor},
   article_location = {Praha},
   article_number = {Supplement 2},
   doi = {http://dx.doi.org/10.33549/physiolres.935099},
   keywords = {Schizophrenia; Cardiovascular diseases; Sigma 1 receptor},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological research},
   title = {Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor},
   url = {https://www.biomed.cas.cz/physiolres/pdf/2023/72_S113.pdf},
   volume = {72},
   year = {2023}
}

TY  - JOUR
ID  - 2305120
AU  - Rafčíková, Julie - Nováková, Marie - Stračina, Tibor
PY  - 2023
TI  - Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor
JF  - Physiological research
VL  - 72
IS  - Supplement 2
SP  - "S113"-"S126"
EP  - "S113"-"S126"
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - Schizophrenia
KW  - Cardiovascular diseases
KW  - Sigma 1 receptor
UR  - https://www.biomed.cas.cz/physiolres/pdf/2023/72_S113.pdf
N2  - Contemporary society is characterized by rapid changes. Various epidemiological, political and economic crises represent a burden to mental health of nowadays population, which may at least partially explain the increasing incidence of mental disorders, including schizophrenia. Schizophrenia is associated with premature mortality by at least 13-15 years. The leading cause of premature mortality in schizophrenia patients is high incidence of cardiovascular diseases. The specific-cause mortality risk for cardiovascular diseases in schizophrenia patients is more than twice higher as compared to the general population. Several factors are discussed as the factor of cardiovascular diseases development. Intensive efforts to identify possible link between schizophrenia and cardiovascular diseases are made. It seems that sigma 1 receptor may represent such link. By modulation of the activity of several neurotransmitter systems, including dopamine, glutamate, and GABA, sigma 1 receptor might play a role in pathophysiology of schizophrenia. Moreover, significant roles of sigma 1 receptor in cardiovascular system have been repeatedly reported. The detailed role of sigma 1 receptor in both schizophrenia and cardiovascular disorders development however remains unclear. The article presents an overview of current knowledge about the association between schizophrenia and cardiovascular diseases and proposes possible explanations with special emphasis on the role of the sigma 1 receptor.
ER  -

RAFČÍKOVÁ, Julie, Marie NOVÁKOVÁ a Tibor STRAČINA. Exploring the Association between Schizophrenia and Cardiovascular Diseases: Insights into the Role of Sigma 1 Receptor. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2023, roč.~72, Supplement 2, s.~''S113''-''S126'', 14 s. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.935099.

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