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@article{2306678,
author = {Samec, Marek and Mazurakova, Alena and Lucansky, Vincent and Koklesova, Lenka and Pecova, Renata and Pec, Martin and Golubnitschaja, Olga and AlandIshaq, Raghad Khalid and Caprnda, Martin and Gaspar, Ludovit and Prosecký, Robert and Gazdikova, Katarina and Adamek, Mariusz and Buesselberg, Dietrich and Kružliak, Peter and Kubatka, Peter},
article_location = {AMSTERDAM},
article_number = {June 2023},
doi = {http://dx.doi.org/10.1016/j.ejphar.2023.175655},
keywords = {Flavonoids; Cancer cells; Carcinogenesis; Metabolism; Metabolic reprogramming},
language = {eng},
issn = {0014-2999},
journal = {European Journal of Pharmacology},
title = {Flavonoids attenuate cancer metabolism by modulating Lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2},
url = {https://www.sciencedirect.com/science/article/pii/S0014299923001668?via%3Dihub},
volume = {949},
year = {2023}
}
TY - JOUR
ID - 2306678
AU - Samec, Marek - Mazurakova, Alena - Lucansky, Vincent - Koklesova, Lenka - Pecova, Renata - Pec, Martin - Golubnitschaja, Olga - Al-Ishaq, Raghad Khalid - Caprnda, Martin - Gaspar, Ludovit - Prosecký, Robert - Gazdikova, Katarina - Adamek, Mariusz - Buesselberg, Dietrich - Kružliak, Peter - Kubatka, Peter
PY - 2023
TI - Flavonoids attenuate cancer metabolism by modulating Lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2
JF - European Journal of Pharmacology
VL - 949
IS - June 2023
SP - 1-19
EP - 1-19
PB - Elsevier
SN - 00142999
KW - Flavonoids
KW - Cancer cells
KW - Carcinogenesis
KW - Metabolism
KW - Metabolic reprogramming
UR - https://www.sciencedirect.com/science/article/pii/S0014299923001668?via%3Dihub
N2 - Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation of cancer cells also involves alterations in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, and utilization of ketone bodies. Also, redox regulation interacts with metabolic reprogramming during malignant transformation. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological cancer phenotype. Recent evidence has identified numerous flavonoids as modulators of critical components of cancer metabolism and associated pathways interacting with metabolic cascades such as redox balance. Flavonoids affect lipid metabolism by regulating fatty acid synthase, redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, or amino acid flux and synthesis by phosphoglycerate mutase 1. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies.
ER -
SAMEC, Marek, Alena MAZURAKOVA, Vincent LUCANSKY, Lenka KOKLESOVA, Renata PECOVA, Martin PEC, Olga GOLUBNITSCHAJA, Raghad Khalid AL-ISHAQ, Martin CAPRNDA, Ludovit GASPAR, Robert PROSECKÝ, Katarina GAZDIKOVA, Mariusz ADAMEK, Dietrich BUESSELBERG, Peter KRUŽLIAK and Peter KUBATKA. Flavonoids attenuate cancer metabolism by modulating Lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2. \textit{European Journal of Pharmacology}. AMSTERDAM: Elsevier, 2023, vol.~949, June 2023, p.~1-19. ISSN~0014-2999. Available from: https://dx.doi.org/10.1016/j.ejphar.2023.175655.
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