Lifelong effects of prenatal and early postnatal stress on the
hippocampus, amygdala, and psychological states of Holocaust
survivors.

J 2023

Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors.

FŇAŠKOVÁ, Monika, Pavel ŘÍHA, Markéta NEČASOVÁ, Marek PREISS, Ivan REKTOR et. al.

Základní údaje

Originální název

Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors.

Autoři

FŇAŠKOVÁ, Monika (203 Česká republika, domácí), Pavel ŘÍHA (203 Česká republika, domácí), Markéta NEČASOVÁ (203 Česká republika, domácí), Marek PREISS (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, garant, domácí)

Vydání

Nature Scientific Reports, London, NATURE RESEARCH, 2023, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600 v roce 2022

Kód RIV

RIV/00216224:14740/23:00131640

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1038/s41598-023-40618-3

UT WoS

001113423900027

Klíčová slova anglicky

GRAY-MATTER; BRAIN; DISORDER; CONSEQUENCES; VOLUME; FEAR; CINGULATE; VERSION; IMPACT; CZECH

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 13:20, Ing. Jana Kuchtová

Anotace

V originále

This study focuses on hippocampal and amygdala volume, seed-based connectivity, and psychological traits of Holocaust survivors who experienced stress during prenatal and early postnatal development. We investigated people who lived in Central Europe during the Holocaust and who, as Jews, were in imminent danger. The group who experienced stress during their prenatal development and early postnatal (PreP) period (n=11) were compared with a group who experienced Holocaust-related stress later in their lives: in late childhood, adolescence, and early adulthood (ChA) (n=21). The results of volumetry analysis showed significantly lower volumes of both hippocampi and the right amygdala in the PreP group. Seed-based connectivity analysis revealed increased connectivity from the seed in the right amygdala to the middle and posterior cingulate cortex, caudate, and inferior left frontal operculum in the PreP group. Psychological testing found higher levels of traumatic stress symptoms (TCS-40) and lower levels of well-being (SOS-10) in the PreP group than in the ChA group. The results of our study demonstrate that extreme stress experienced during prenatal and early postnatal life has a profound lifelong impact on the hippocampus and amygdala and on several psychological characteristics.

Návaznosti

NV18-04-00559, projekt VaV

Název: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků

Investor: Ministerstvo zdravotnictví ČR, Neurobiologické a psychologické markery reakce na extrémní stres a dopad na generace potomků - třígenerační studie přeživších holokaust a jejich potomků

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

90250, velká výzkumná infrastruktura

Název: Czech-BioImaging III

Citovat

FŇAŠKOVÁ, Monika, Pavel ŘÍHA, Markéta NEČASOVÁ, Marek PREISS a Ivan REKTOR. Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors. Nature Scientific Reports. London: NATURE RESEARCH, 2023, roč. 13, č. 1, s. 1-9. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-023-40618-3.

@article{2308505,
   author = {Fňašková, Monika and Říha, Pavel and Nečasová, Markéta and Preiss, Marek and Rektor, Ivan},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-023-40618-3},
   keywords = {GRAY-MATTER; BRAIN; DISORDER; CONSEQUENCES; VOLUME; FEAR; CINGULATE; VERSION; IMPACT; CZECH},
   language = {eng},
   issn = {2045-2322},
   journal = {Nature Scientific Reports},
   title = {Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors.},
   url = {https://www.nature.com/articles/s41598-023-40618-3},
   volume = {13},
   year = {2023}
}

TY  - JOUR
ID  - 2308505
AU  - Fňašková, Monika - Říha, Pavel - Nečasová, Markéta - Preiss, Marek - Rektor, Ivan
PY  - 2023
TI  - Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors.
JF  - Nature Scientific Reports
VL  - 13
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - NATURE RESEARCH
SN  - 20452322
KW  - GRAY-MATTER
KW  - BRAIN
KW  - DISORDER
KW  - CONSEQUENCES
KW  - VOLUME
KW  - FEAR
KW  - CINGULATE
KW  - VERSION
KW  - IMPACT
KW  - CZECH
UR  - https://www.nature.com/articles/s41598-023-40618-3
N2  - This study focuses on hippocampal and amygdala volume, seed-based connectivity, and psychological traits of Holocaust survivors who experienced stress during prenatal and early postnatal development. We investigated people who lived in Central Europe during the Holocaust and who, as Jews, were in imminent danger. The group who experienced stress during their prenatal development and early postnatal (PreP) period (n=11) were compared with a group who experienced Holocaust-related stress later in their lives: in late childhood, adolescence, and early adulthood (ChA) (n=21). The results of volumetry analysis showed significantly lower volumes of both hippocampi and the right amygdala in the PreP group. Seed-based connectivity analysis revealed increased connectivity from the seed in the right amygdala to the middle and posterior cingulate cortex, caudate, and inferior left frontal operculum in the PreP group. Psychological testing found higher levels of traumatic stress symptoms (TCS-40) and lower levels of well-being (SOS-10) in the PreP group than in the ChA group. The results of our study demonstrate that extreme stress experienced during prenatal and early postnatal life has a profound lifelong impact on the hippocampus and amygdala and on several psychological characteristics.
ER  -

FŇAŠKOVÁ, Monika, Pavel ŘÍHA, Markéta NEČASOVÁ, Marek PREISS a Ivan REKTOR. Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychological states of Holocaust survivors. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2023, roč.~13, č.~1, s.~1-9. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-023-40618-3.

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