Další formáty:
BibTeX
LaTeX
RIS
@proceedings{2312919,
author = {Pelcová, Marta and Štolcová, Miriam and Smutná, Jindra and Juřica, Jan and Peš, Ondřej and Glatz, Zdeněk},
booktitle = {29th International Symposium on Electro- and Liquid-Phase Separation Techniques, ITP2023},
keywords = {antiepileptics, LC-MS, quantification, saliva},
language = {eng},
title = {Determination of selected antiepileptics in saliva and the potential of LC-MS mehod for quantification},
year = {2023}
}
TY - CONF
ID - 2312919
AU - Pelcová, Marta - Štolcová, Miriam - Smutná, Jindra - Juřica, Jan - Peš, Ondřej - Glatz, Zdeněk
PY - 2023
TI - Determination of selected antiepileptics in saliva and the potential of LC-MS mehod for quantification
KW - antiepileptics, LC-MS, quantification, saliva
N2 - Antiepileptic drugs (AED) with anticonvulsive properties represent suitable medication for epilepsy treatmnet. Apart the plasma/serum matrix, saliva is the other suitable source of clinical data on drug concentration and therapy compliance. Saliva based diagnostics could help improve personalized medicine and be the tool for long-term monitoring. In this study, the LC-MS method for AED determination was developed and underwent basic validation. The presented LC-MS method is suitable for quantification of selected drugs. The validation criteria were fulfilled for all analytes except for levetiracetam. Further studies will be focused of the quantification of AED drugs in patient samples and the correlation of the salivary to plasma concentrations.
ER -
PELCOVÁ, Marta, Miriam ŠTOLCOVÁ, Jindra SMUTNÁ, Jan JUŘICA, Ondřej PEŠ a Zdeněk GLATZ. Determination of selected antiepileptics in saliva and the potential of LC-MS mehod for quantification. In \textit{29th International Symposium on Electro- and Liquid-Phase Separation Techniques, ITP2023}. 2023.
|
