Olfactory Bulbectomy Model of Depression Lowers Responding for Food in Male and Female Rats: The Modulating Role of Caloric Restriction and Response Requirement

FATTORE, Liana, Petra AMCHOVÁ, Paola FADDA and Jana RUDÁ. Olfactory Bulbectomy Model of Depression Lowers Responding for Food in Male and Female Rats: The Modulating Role of Caloric Restriction and Response Requirement. BIOMEDICINES. BASEL: MDPI, 2023, vol. 11, No 9, p. 1-15. ISSN 2227-9059. Available from: https://dx.doi.org/10.3390/biomedicines11092481.

Basic information

• Original name: Olfactory Bulbectomy Model of Depression Lowers Responding for Food in Male and Female Rats: The Modulating Role of Caloric Restriction and Response Requirement
• Name in Czech: Model deprese navozené olfaktorickou bulbektomií snižuje operantní příjem potravy u samců a samic potkanů: Modulující úloha kalorické restrikce a operantního požadavku
• Authors: FATTORE, Liana (380 Italy), Petra AMCHOVÁ (203 Czech Republic, belonging to the institution), Paola FADDA (380 Italy) and Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: BIOMEDICINES, BASEL, MDPI, 2023, 2227-9059.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.700 in 2022
• RIV identification code: RIV/00216224:14110/23:00131763
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.3390/biomedicines11092481
• UT WoS: 001074336500001
• Keywords in English: olfactory bulbectomy; depression; reward; self-administration; sex; strain
• Tags: 14110516, rivok
• Tags: International impact, Reviewed

Abstract

In summary, this study showed that bulbectomy significantly reduces operant responding and food intake in male and female Sprague–Dawley rats while inducing a mild reducing effect only in the Wistar strain.

Abstract (in Czech)

Souhrnně tato studie ukázala, že bulbektomie významně snižuje operantní příjem potravy u samců a samic potkanů kmene Sprague-Dawley, zatímco u kmene Wistar vyvolává pouze mírný účinek.

Links

• MUNI/A/1342/2022, interní kód MU: Name: Preklinický a klinický výzkum v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masaryk University, Preclinical and clinical research in pharmacokinetics, neuropsychopharmacology and personalized pharmacotherapy in oncology