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@article{2327097,
author = {Klail, Tomáš and Šedová, Petra and Vinklárek, Jan and Kovacova, Ingrid and Bar, Michal and Cihlar, Filip and Cernik, David and Koci, Lubomir and Jura, René and Herzig, Roman and Hustý, Jakub and Kocher, Martin and Kovar, Martin and Nevsimalova, Miroslava and Raupach, Jan and Rocek, Miloslav and Sanak, Daniel and Sevcik, Petr and Skoloudik, David and Sramek, Martin and Vaníček, Jiří and Vasko, Peter and Vaclavik, Daniel and Tomek, Ales and Mikulík, Robert},
article_location = {New York},
article_number = {9},
doi = {http://dx.doi.org/10.1016/j.jvir.2023.05.017},
keywords = {THERAPYTHROMBOLYSISMETAANALYSISGUIDELINESOUTCOMES},
language = {eng},
issn = {1051-0443},
journal = {Journal of vascular and interventional radiology},
title = {Safety and Efficacy of Baseline Antiplatelet Treatment in Patients Undergoing Mechanical Thrombectomy for Ischemic Stroke: Antiplatelets Before Mechanical Thrombectomy},
url = {https://www.sciencedirect.com/science/article/pii/S1051044323003494?via%3Dihub},
volume = {34},
year = {2023}
}
TY - JOUR
ID - 2327097
AU - Klail, Tomáš - Šedová, Petra - Vinklárek, Jan - Kovacova, Ingrid - Bar, Michal - Cihlar, Filip - Cernik, David - Koci, Lubomir - Jura, René - Herzig, Roman - Hustý, Jakub - Kocher, Martin - Kovar, Martin - Nevsimalova, Miroslava - Raupach, Jan - Rocek, Miloslav - Sanak, Daniel - Sevcik, Petr - Skoloudik, David - Sramek, Martin - Vaníček, Jiří - Vasko, Peter - Vaclavik, Daniel - Tomek, Ales - Mikulík, Robert
PY - 2023
TI - Safety and Efficacy of Baseline Antiplatelet Treatment in Patients Undergoing Mechanical Thrombectomy for Ischemic Stroke: Antiplatelets Before Mechanical Thrombectomy
JF - Journal of vascular and interventional radiology
VL - 34
IS - 9
SP - "1502"-"1512.e12"
EP - "1502"-"1512.e12"
PB - ELSEVIER
SN - 10510443
KW - THERAPYTHROMBOLYSISMETAANALYSISGUIDELINESOUTCOMES
UR - https://www.sciencedirect.com/science/article/pii/S1051044323003494?via%3Dihub
N2 - Purpose: To investigate the safety and efficacy of baseline antiplatelet treatment in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy (MT). Materials and Methods: Baseline use of antiplatelet medication before MT for (AIS) may provide benefit on reperfusion and clinical outcome but could also carry an increased risk of intracranial hemorrhage (ICH). All consecutive patients with AIS and treated with MT with and without intravenous thrombolysis (IVT) between January 2012 and December 2019 in all centers performing MT nationwide were reviewed. Data were prospectively collected in national registries (eg, SITS-TBY and RES-Q). Primary outcome was functional independence (modified Rankin Scale 0-2) at 3 months; secondary outcome was ICH. Results: Of the 4,351 patients who underwent MT, 1,750 (40%) and 666 (15%) were excluded owing to missing data from the functional independence and ICH outcome cohorts, respectively. In the functional independence cohort (n = 2,601), 771 (30%) patients received antiplatelets before MT. Favorable outcome did not differ in any antiplatelet, aspirin, and clopidogrel groups when compared with that in the no-antiplatelet group: odds ratio (OR), 1.00 (95% CI, 0.84-1.20); OR, 1.05 (95% CI, 0.86-1.27); and OR, 0.88 (95% CI, 0.55-1.41), respectively. In the ICH cohort (n = 3,685), 1095 (30%) patients received antiplatelets before MT. The rates of ICH did not increase in any treatment options (any antiplatelet, aspirin, clopidogrel, and dual antiplatelet groups) when compared with those in the no-antiplatelet group: OR, 1.03 (95% CI, 0.87-1.21); OR, 0.99 (95% CI, 0.83-1.18); OR, 1.10 (95% CI, 0.82-1.47); and OR, 1.43 (95% CI, 0.87-2.33), respectively. Conclusions: Antiplatelet monotherapy before MT did not improve functional independence or increase the risk of ICH.
ER -
KLAIL, Tomáš, Petra ŠEDOVÁ, Jan VINKLÁREK, Ingrid KOVACOVA, Michal BAR, Filip CIHLAR, David CERNIK, Lubomir KOCI, René JURA, Roman HERZIG, Jakub HUSTÝ, Martin KOCHER, Martin KOVAR, Miroslava NEVSIMALOVA, Jan RAUPACH, Miloslav ROCEK, Daniel SANAK, Petr SEVCIK, David SKOLOUDIK, Martin SRAMEK, Jiří VANÍČEK, Peter VASKO, Daniel VACLAVIK, Ales TOMEK and Robert MIKULÍK. Safety and Efficacy of Baseline Antiplatelet Treatment in Patients Undergoing Mechanical Thrombectomy for Ischemic Stroke: Antiplatelets Before Mechanical Thrombectomy. \textit{Journal of vascular and interventional radiology}. New York: ELSEVIER, 2023, vol.~34, No~9, p.~''1502''-''1512.e12'', 21 pp. ISSN~1051-0443. Available from: https://dx.doi.org/10.1016/j.jvir.2023.05.017.
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