Plasma concentrations of levobupivacaine in neonates during
caudal epidural analgesia maintained over 48 hours

J 2023

Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours

SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK et. al.

Základní údaje

Originální název

Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours

Autoři

SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK, Jitka STYBLOVA, Vladimír MIXA (203 Česká republika, garant, domácí) a Barbora NEDOMOVA

Vydání

Bratislava Medical Journal - Bratislavské lekárske listy, BRATISLAVA, Univerzita Komenského, 2023, 0006-9248

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30230 Other clinical medicine subjects

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.500 v roce 2022

Kód RIV

RIV/00216224:14110/23:00131955

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/BLL_2023_018

UT WoS

000916937100005

Klíčová slova česky

free levobupivacaine; total levobupivacaine; neonate; caudal continuous epidural analgesia; postoperative pain

Klíčová slova anglicky

free levobupivacaine; total levobupivacaine; neonate; caudal continuous epidural analgesia; postoperative pain

Štítky

Excelence Science, FN MOTOL, RIV, user, VFN, článek v časopise

Příznaky

Mezinárodní význam

Změněno: 11. 1. 2024 10:50, Bc. Hana Vladíková, BBA

Anotace

V originále

BACKGROUND: Differences in neonatal pharmacokinetics are known to cause systemic accumulation of levobupivacaine with adverse effects during epidural analgesia. Therefore, it is not recommended to surpass 48 hours of administration in neonates. Free and total levobupivacaine levels are considered as predictors of toxicity.

Návaznosti

90249, velká výzkumná infrastruktura

Název: CZECRIN IV

Citovat

SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK, Jitka STYBLOVA, Vladimír MIXA a Barbora NEDOMOVA. Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours. Bratislava Medical Journal - Bratislavské lekárske listy. BRATISLAVA: Univerzita Komenského, 2023, roč. 124, č. 2, s. 116-120. ISSN 0006-9248. Dostupné z: https://dx.doi.org/10.4149/BLL_2023_018.

@article{2327140,
   author = {Sipek, Jan and Pokorna, Pavla and Sima, Martin and Berka, Ivan and Hlozek, Tomas and Styblova, Jitka and Mixa, Vladimír and Nedomova, Barbora},
   article_location = {BRATISLAVA},
   article_number = {2},
   doi = {http://dx.doi.org/10.4149/BLL_2023_018},
   keywords = {free levobupivacaine; total levobupivacaine; neonate; caudal continuous epidural analgesia; postoperative pain},
   language = {eng},
   issn = {0006-9248},
   journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
   title = {Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours},
   url = {http://www.elis.sk/download_file.php?product_id=7918&session_id=cd662gp9iqhqdidiu9pr02vda0},
   volume = {124},
   year = {2023}
}

TY  - JOUR
ID  - 2327140
AU  - Sipek, Jan - Pokorna, Pavla - Sima, Martin - Berka, Ivan - Hlozek, Tomas - Styblova, Jitka - Mixa, Vladimír - Nedomova, Barbora
PY  - 2023
TI  - Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours
JF  - Bratislava Medical Journal - Bratislavské lekárske listy
VL  - 124
IS  - 2
SP  - 116-120
EP  - 116-120
PB  - Univerzita Komenského
SN  - 00069248
KW  - free levobupivacaine
KW  - total levobupivacaine
KW  - neonate
KW  - caudal continuous epidural analgesia
KW  - postoperative pain
UR  - http://www.elis.sk/download_file.php?product_id=7918&session_id=cd662gp9iqhqdidiu9pr02vda0
N2  - BACKGROUND: Differences in neonatal pharmacokinetics are known to cause systemic accumulation of levobupivacaine with adverse effects during epidural analgesia. Therefore, it is not recommended to surpass 48 hours of administration in neonates. Free and total levobupivacaine levels are considered as predictors of toxicity.
ER  -

SIPEK, Jan, Pavla POKORNA, Martin SIMA, Ivan BERKA, Tomas HLOZEK, Jitka STYBLOVA, Vladimír MIXA a Barbora NEDOMOVA. Plasma concentrations of levobupivacaine in neonates during caudal epidural analgesia maintained over 48 hours. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2023, roč.~124, č.~2, s.~116-120. ISSN~0006-9248. Dostupné z: https://dx.doi.org/10.4149/BLL\_{}2023\_{}018.

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