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@article{2330527,
author = {Bresciani, Giulio and Červinka, Jakub and Kostrhunová, Hana and Biancalana, Lorenzo and Bortoluzzi, Marco and Pampaloni, Guido and Novohradský, Vojtěch and Brabec, Viktor and Marchetti, Fabio and Kašpárková, Jana},
article_number = {November},
doi = {http://dx.doi.org/10.1016/j.cbi.2023.110742},
keywords = {Diiron complexes; Indole; Anticancer; Mitochondria; ROS; Antioxidant},
language = {eng},
issn = {0009-2797},
journal = {Chemico-Biological Interactions},
title = {N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity},
url = {https://doi.org/10.1016/j.cbi.2023.110742},
volume = {385},
year = {2023}
}
TY - JOUR
ID - 2330527
AU - Bresciani, Giulio - Červinka, Jakub - Kostrhunová, Hana - Biancalana, Lorenzo - Bortoluzzi, Marco - Pampaloni, Guido - Novohradský, Vojtěch - Brabec, Viktor - Marchetti, Fabio - Kašpárková, Jana
PY - 2023
TI - N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity
JF - Chemico-Biological Interactions
VL - 385
IS - November
SP - 1-15
EP - 1-15
PB - Elsevier B.V
SN - 00092797
KW - Diiron complexes
KW - Indole
KW - Anticancer
KW - Mitochondria
KW - ROS
KW - Antioxidant
UR - https://doi.org/10.1016/j.cbi.2023.110742
N2 - The indole scaffold has been established as a key organic moiety for developing new drugs; on the other hand, a range of diiron bis-cyclopentadienyl complexes have recently emerged for their promising anticancer potential. Here, we report the synthesis of novel diiron complexes with an indole-functionalized vinyliminium ligand (2–5) and an indole-lacking analogue for comparative purposes (6), which were characterized by analytical and spectroscopic techniques. Complexes 2–6 are substantially stable in DMSO‑d6 and DMEM-d solutions at 37 °C (8% average degradation after 48 h) and display a balanced hydrophilic/lipophilic behaviour (LogPow values in the range −0.32 to 0.47), associated with appreciable water solubility. The complexes display selective antiproliferative potency towards several cancer cells in monolayer cultures, mainly in the low micromolar range, with reduced toxicity towards noncancerous epithelial cells. Thus, the cytotoxicity of the complexes is comparable to or better than clinically used metallopharmaceutical cisplatin. Comparing the antiproliferative activity obtained for complexes containing different ligands, we confirmed the importance of the indolyl group in the mechanism of antiproliferative activity of these complexes. Cell-based mechanistic studies suggest that the investigated diiron vinyliminium complexes (DVCs) show cytostatic rather than cytotoxic effects and subsequently induce a population of cells to undergo apoptosis. Furthermore, the molecular mechanism of action involves interactions with mitochondrial DNA and proteins, the reactive oxygen species (ROS)-scavenging properties and antioxidant activity of these complexes in cancer cells. This study highlights the importance of DVCs to their cancer cell activity and reinforces their prospective therapeutic potential as anticancer agents.
ER -
BRESCIANI, Giulio, Jakub ČERVINKA, Hana KOSTRHUNOVÁ, Lorenzo BIANCALANA, Marco BORTOLUZZI, Guido PAMPALONI, Vojtěch NOVOHRADSKÝ, Viktor BRABEC, Fabio MARCHETTI a Jana KAŠPÁRKOVÁ. N-Indolyl diiron vinyliminium complexes exhibit antiproliferative effects in cancer cells associated with disruption of mitochondrial homeostasis, ROS scavenging, and antioxidant activity. \textit{Chemico-Biological Interactions}. Elsevier B.V, 2023, roč.~385, November, s.~1-15. ISSN~0009-2797. Dostupné z: https://dx.doi.org/10.1016/j.cbi.2023.110742.
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