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@article{2332057,
author = {Kincl, Vladimír and Panovský, Roman and Bočková, Martina and Rektor, Ivan and MojicaandPisciotti, Mary Luz and Máchal, Jan},
article_location = {HOBOKEN},
article_number = {2},
doi = {http://dx.doi.org/10.1111/ene.16110},
keywords = {Parkinson´s disease; cardiovascular symptoms},
language = {eng},
issn = {1351-5101},
journal = {European Journal of Neurology},
title = {Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight},
url = {https://onlinelibrary.wiley.com/doi/10.1111/ene.16110},
volume = {31},
year = {2024}
}
TY - JOUR
ID - 2332057
AU - Kincl, Vladimír - Panovský, Roman - Bočková, Martina - Rektor, Ivan - Mojica-Pisciotti, Mary Luz - Máchal, Jan
PY - 2024
TI - Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight
JF - European Journal of Neurology
VL - 31
IS - 2
SP - 1-9
EP - 1-9
PB - WILEY
SN - 13515101
KW - Parkinson´s disease
KW - cardiovascular symptoms
UR - https://onlinelibrary.wiley.com/doi/10.1111/ene.16110
N2 - Background The known impairments of the cardiovascular system in Parkinson´s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research. Objectives To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients. Methods Thirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR). Results PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p < 0.01), peak SBP (155.8 vs. 170.8 mmHg, p < 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p < 0.01). PD patients had higher indexed left and right ventricular end-diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m2, respectively) and also indexed left and right ventricular end-systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m2, p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found. Conclusions This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.
ER -
KINCL, Vladimír, Roman PANOVSKÝ, Martina BOČKOVÁ, Ivan REKTOR, Mary Luz MOJICA-PISCIOTTI a Jan MÁCHAL. Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight. \textit{European Journal of Neurology}. HOBOKEN: WILEY, 2024, roč.~31, č.~2, s.~1-9. ISSN~1351-5101. Dostupné z: https://dx.doi.org/10.1111/ene.16110.
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