Parkinson´s disease cardiovascular symptoms: A new complex
functional and structural insight

J 2024

Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight

KINCL, Vladimír, Roman PANOVSKÝ, Martina BOČKOVÁ, Ivan REKTOR, Mary Luz MOJICA-PISCIOTTI et. al.

Základní údaje

Originální název

Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight

Autoři

KINCL, Vladimír (203 Česká republika, domácí), Roman PANOVSKÝ (203 Česká republika, domácí), Martina BOČKOVÁ (203 Česká republika, domácí), Ivan REKTOR (203 Česká republika, domácí), Mary Luz MOJICA-PISCIOTTI a Jan MÁCHAL (203 Česká republika, domácí)

Vydání

European Journal of Neurology, HOBOKEN, WILEY, 2024, 1351-5101

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.100 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/ene.16110

UT WoS

001091935300001

Klíčová slova anglicky

Parkinson´s disease; cardiovascular symptoms

Štítky

14110115, 14110132, 14110518, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 4. 2024 14:20, Mgr. Eva Dubská

Anotace

V originále

Background The known impairments of the cardiovascular system in Parkinson´s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research. Objectives To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients. Methods Thirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR). Results PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p < 0.01), peak SBP (155.8 vs. 170.8 mmHg, p < 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p < 0.01). PD patients had higher indexed left and right ventricular end-diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m2, respectively) and also indexed left and right ventricular end-systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m2, p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found. Conclusions This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.

Návaznosti

NU21-04-00445, projekt VaV

Název: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit (Akronym: DBScomorbidities)

Investor: Ministerstvo zdravotnictví ČR, Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit, Podprogram 1 - standardní

Citovat

KINCL, Vladimír, Roman PANOVSKÝ, Martina BOČKOVÁ, Ivan REKTOR, Mary Luz MOJICA-PISCIOTTI a Jan MÁCHAL. Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight. European Journal of Neurology. HOBOKEN: WILEY, 2024, roč. 31, č. 2, s. 1-9. ISSN 1351-5101. Dostupné z: https://dx.doi.org/10.1111/ene.16110.

@article{2332057,
   author = {Kincl, Vladimír and Panovský, Roman and Bočková, Martina and Rektor, Ivan and MojicaandPisciotti, Mary Luz and Máchal, Jan},
   article_location = {HOBOKEN},
   article_number = {2},
   doi = {http://dx.doi.org/10.1111/ene.16110},
   keywords = {Parkinson´s disease; cardiovascular symptoms},
   language = {eng},
   issn = {1351-5101},
   journal = {European Journal of Neurology},
   title = {Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/ene.16110},
   volume = {31},
   year = {2024}
}

TY  - JOUR
ID  - 2332057
AU  - Kincl, Vladimír - Panovský, Roman - Bočková, Martina - Rektor, Ivan - Mojica-Pisciotti, Mary Luz - Máchal, Jan
PY  - 2024
TI  - Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight
JF  - European Journal of Neurology
VL  - 31
IS  - 2
SP  - 1-9
EP  - 1-9
PB  - WILEY
SN  - 13515101
KW  - Parkinson´s disease
KW  - cardiovascular symptoms
UR  - https://onlinelibrary.wiley.com/doi/10.1111/ene.16110
N2  - Background The known impairments of the cardiovascular system in Parkinson´s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research. Objectives To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients. Methods Thirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR). Results PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p < 0.01), peak SBP (155.8 vs. 170.8 mmHg, p < 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p < 0.01). PD patients had higher indexed left and right ventricular end-diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m2, respectively) and also indexed left and right ventricular end-systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m2, p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found. Conclusions This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.
ER  -

KINCL, Vladimír, Roman PANOVSKÝ, Martina BOČKOVÁ, Ivan REKTOR, Mary Luz MOJICA-PISCIOTTI a Jan MÁCHAL. Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight. \textit{European Journal of Neurology}. HOBOKEN: WILEY, 2024, roč.~31, č.~2, s.~1-9. ISSN~1351-5101. Dostupné z: https://dx.doi.org/10.1111/ene.16110.

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