Mucormycosis in a Severe Trauma Patient Treated with a
Combination of Systemic Posaconazole and Topical Amphotericin
B—Case Report

J 2023

Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report

KELLER, Filip, Helena ANTONI, Petra MINARČÍKOVÁ, Ondřej HRDÝ, Roman GÁL et. al.

Základní údaje

Originální název

Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report

Autoři

KELLER, Filip (203 Česká republika, domácí), Helena ANTONI (203 Česká republika, domácí), Petra MINARČÍKOVÁ (203 Česká republika, domácí), Ondřej HRDÝ (203 Česká republika, domácí) a Roman GÁL (203 Česká republika, domácí)

Vydání

Antibiotics, BASEL, MDPI, 2023, 2079-6382

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30223 Anaesthesiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.800 v roce 2022

Kód RIV

RIV/00216224:14110/23:00132096

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/antibiotics12101489

UT WoS

001090604100001

Klíčová slova anglicky

mucormycosis; posaconazole; amphotericin B; severe trauma; case report

Štítky

14110233, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 1. 2024 14:52, Mgr. Tereza Miškechová

Anotace

V originále

Mucormycosis is an opportunistic infection affecting mainly immunocompromised hosts. Infection in immunocompetent patients is rare, but may occur typically in trauma or burn victims. We report on a previously healthy young man suffering devastating trauma from an agricultural accident with the subsequent development of a multifocal mucormycosis. Diagnosis was achieved by cultures obtained from non-healing wounds, some of them even covered by a macroscopic mold formation. Specific treatment was initiated soon after the preliminary results indicated mucormycosis. Aggressive surgical therapy, with concomitant use of systemic posaconazole and topical amphotericin B in a combination treatment, led to the elimination of the fungal infection. The remaining deep tissue defects were consequently reconstructed by a muscle flap and skin graft autotransplantation with a good overall outcome, which would not have been possible without the complete remission of mucormycosis. This case study presents the successful use of a combination treatment with systemic posaconazole and topical amphotericin B and underlines the importance of timely and aggressive surgical therapy.

Návaznosti

MUNI/A/1336/2022, interní kód MU

Název: Vliv profylaktického podání fibrinogenu na velikost krevní ztráty u operací skoliózy: Monocentrická randomizovaná pilotní studie

Investor: Masarykova univerzita, Vliv profylaktického podání fibrinogenu na velikost krevní ztráty u operací skoliózy: Monocentrická randomizovaná pilotní studie

Citovat

KELLER, Filip, Helena ANTONI, Petra MINARČÍKOVÁ, Ondřej HRDÝ a Roman GÁL. Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report. Antibiotics. BASEL: MDPI, 2023, roč. 12, č. 10, s. 1-7. ISSN 2079-6382. Dostupné z: https://dx.doi.org/10.3390/antibiotics12101489.

@article{2333257,
   author = {Keller, Filip and Antoni, Helena and Minarčíková, Petra and Hrdý, Ondřej and Gál, Roman},
   article_location = {BASEL},
   article_number = {10},
   doi = {http://dx.doi.org/10.3390/antibiotics12101489},
   keywords = {mucormycosis; posaconazole; amphotericin B; severe trauma; case report},
   language = {eng},
   issn = {2079-6382},
   journal = {Antibiotics},
   title = {Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report},
   url = {https://www.mdpi.com/2079-6382/12/10/1489},
   volume = {12},
   year = {2023}
}

TY  - JOUR
ID  - 2333257
AU  - Keller, Filip - Antoni, Helena - Minarčíková, Petra - Hrdý, Ondřej - Gál, Roman
PY  - 2023
TI  - Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report
JF  - Antibiotics
VL  - 12
IS  - 10
SP  - 1-7
EP  - 1-7
PB  - MDPI
SN  - 20796382
KW  - mucormycosis
KW  - posaconazole
KW  - amphotericin B
KW  - severe trauma
KW  - case report
UR  - https://www.mdpi.com/2079-6382/12/10/1489
N2  - Mucormycosis is an opportunistic infection affecting mainly immunocompromised hosts. Infection in immunocompetent patients is rare, but may occur typically in trauma or burn victims. We report on a previously healthy young man suffering devastating trauma from an agricultural accident with the subsequent development of a multifocal mucormycosis. Diagnosis was achieved by cultures obtained from non-healing wounds, some of them even covered by a macroscopic mold formation. Specific treatment was initiated soon after the preliminary results indicated mucormycosis. Aggressive surgical therapy, with concomitant use of systemic posaconazole and topical amphotericin B in a combination treatment, led to the elimination of the fungal infection. The remaining deep tissue defects were consequently reconstructed by a muscle flap and skin graft autotransplantation with a good overall outcome, which would not have been possible without the complete remission of mucormycosis. This case study presents the successful use of a combination treatment with systemic posaconazole and topical amphotericin B and underlines the importance of timely and aggressive surgical therapy.
ER  -

KELLER, Filip, Helena ANTONI, Petra MINARČÍKOVÁ, Ondřej HRDÝ a Roman GÁL. Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B—Case Report. \textit{Antibiotics}. BASEL: MDPI, 2023, roč.~12, č.~10, s.~1-7. ISSN~2079-6382. Dostupné z: https://dx.doi.org/10.3390/antibiotics12101489.

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