Role of genetics in the development of cardiac allograft
vasculopathy

J 2023

Role of genetics in the development of cardiac allograft vasculopathy

MAYEROVA, Lucie, Anna CHALOUPKA, Peter WOHLFAHRT, Jaroslav Alois HUBACEK, Helena BEDANOVA et. al.

Základní údaje

Originální název

Role of genetics in the development of cardiac allograft vasculopathy

Autoři

MAYEROVA, Lucie (203 Česká republika), Anna CHALOUPKA (203 Česká republika, domácí), Peter WOHLFAHRT (203 Česká republika), Jaroslav Alois HUBACEK (203 Česká republika), Helena BEDANOVA (203 Česká republika), Zhi CHEN, Josef KAUTZNER (203 Česká republika), Vojtech MELENOVSKY (203 Česká republika), Ivan MALEK (203 Česká republika), Ales TOMASEK (203 Česká republika), Eva OZÁBALOVÁ (203 Česká republika, domácí), Jan KREJČÍ (203 Česká republika, domácí), Tomas KOVARNIK (203 Česká republika), Milan SONKA (203 Česká republika) a Michal PAZDERNIK (203 Česká republika, garant)

Vydání

Bratislava Medical Journal - Bratislavské lekárske listy, BRATISLAVA, Univerzita Komenského, 2023, 0006-9248

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.500 v roce 2022

Kód RIV

RIV/00216224:14110/23:00132170

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/BLL_2023_031

UT WoS

000944162900006

Klíčová slova anglicky

cardiac allograft vasculopathy; optical coherence tomography; vascular endothelial growth factor A; intimal thickening; genetic polymorphism

Štítky

14110115, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 2. 2024 12:00, Mgr. Tereza Miškechová

Anotace

V originále

BACKGROUND: The association between genetic polymorphisms and early cardiac allograft vasculopathy (CAV) development is relatively unexplored. Identification of genes involved in the CAV process may offer new insights into pathophysiology and lead to a wider range of therapeutic options.METHODS: This prospective study of 109 patients investigated 44 single nucleotide polymorphisms (SNPs) within the susceptibility loci potentially related to coronary artery disease, carotid artery intima-media thickness (cIMT), and in nitric oxide synthase gene. Genotyping was done by the Fluidigm SNP Type assays and Fluidigm 48.48 Dynamic Array IFC. The intima thickness progression (IT) was evaluated by coronary optical coherence tomography (OCT) performed 1 month and 12 months after heart transplantation (HTx).RESULTS: During the first post-HTx year, the mean intima thickness (IT) increased by 24.0 +/- 34.2 mu m (p < 0.001) and lumen area decreased by -0.9 +/- 1.8 mm2 (p < 0.001). The rs1570360 (A/G) SNP of the vascular endothelial growth factor A (VEGFA) gene showed the strongest association with intima thickness progression, even in the presence of the traditional CAV risk factors. SNPs previously related to carotid artery intima-media thickness rs11785239 (PRAG1), rs6584389 (PAX2), rs13225723 (LINC02577) and rs17477177 (CCDC71L), were among the five most significantly associated with IT progression but lost their significance once traditional CAV risk factors had been added.CONCLUSION: Results of this study suggest that genetic variability may play an important role in CAV development. The vascular endothelial growth factor A gene SNP rs1570360 showed the strongest association with intima thickness (IT) progression measured by OCT, even in the presence of the traditional CAV risk factors (Tab. 3, Fig. 3, Ref. 36). Text in PDF www.elis.sk

Návaznosti

MUNI/A/1410/2022, interní kód MU

Název: Nové trendy v diagnostice a managementu srdečních onemocnění

Investor: Masarykova univerzita, Nové trendy v diagnostice a managementu srdečních onemocnění

Citovat

MAYEROVA, Lucie, Anna CHALOUPKA, Peter WOHLFAHRT, Jaroslav Alois HUBACEK, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Ivan MALEK, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Tomas KOVARNIK, Milan SONKA a Michal PAZDERNIK. Role of genetics in the development of cardiac allograft vasculopathy. Bratislava Medical Journal - Bratislavské lekárske listy. BRATISLAVA: Univerzita Komenského, 2023, roč. 124, č. 3, s. 193-200. ISSN 0006-9248. Dostupné z: https://dx.doi.org/10.4149/BLL_2023_031.

@article{2335857,
   author = {Mayerova, Lucie and Chaloupka, Anna and Wohlfahrt, Peter and Hubacek, Jaroslav Alois and Bedanova, Helena and Chen, Zhi and Kautzner, Josef and Melenovsky, Vojtech and Malek, Ivan and Tomasek, Ales and Ozábalová, Eva and Krejčí, Jan and Kovarnik, Tomas and Sonka, Milan and Pazdernik, Michal},
   article_location = {BRATISLAVA},
   article_number = {3},
   doi = {http://dx.doi.org/10.4149/BLL_2023_031},
   keywords = {cardiac allograft vasculopathy; optical coherence tomography; vascular endothelial growth factor A; intimal thickening; genetic polymorphism},
   language = {eng},
   issn = {0006-9248},
   journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
   title = {Role of genetics in the development of cardiac allograft vasculopathy},
   url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7931&category_id=187&option=com_virtuemart&vmcchk=1&Itemid=1},
   volume = {124},
   year = {2023}
}

TY  - JOUR
ID  - 2335857
AU  - Mayerova, Lucie - Chaloupka, Anna - Wohlfahrt, Peter - Hubacek, Jaroslav Alois - Bedanova, Helena - Chen, Zhi - Kautzner, Josef - Melenovsky, Vojtech - Malek, Ivan - Tomasek, Ales - Ozábalová, Eva - Krejčí, Jan - Kovarnik, Tomas - Sonka, Milan - Pazdernik, Michal
PY  - 2023
TI  - Role of genetics in the development of cardiac allograft vasculopathy
JF  - Bratislava Medical Journal - Bratislavské lekárske listy
VL  - 124
IS  - 3
SP  - 193-200
EP  - 193-200
PB  - Univerzita Komenského
SN  - 00069248
KW  - cardiac allograft vasculopathy
KW  - optical coherence tomography
KW  - vascular endothelial growth factor A
KW  - intimal thickening
KW  - genetic polymorphism
UR  - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7931&category_id=187&option=com_virtuemart&vmcchk=1&Itemid=1
N2  - BACKGROUND: The association between genetic polymorphisms and early cardiac allograft vasculopathy (CAV) development is relatively unexplored. Identification of genes involved in the CAV process may offer new insights into pathophysiology and lead to a wider range of therapeutic options.METHODS: This prospective study of 109 patients investigated 44 single nucleotide polymorphisms (SNPs) within the susceptibility loci potentially related to coronary artery disease, carotid artery intima-media thickness (cIMT), and in nitric oxide synthase gene. Genotyping was done by the Fluidigm SNP Type assays and Fluidigm 48.48 Dynamic Array IFC. The intima thickness progression (IT) was evaluated by coronary optical coherence tomography (OCT) performed 1 month and 12 months after heart transplantation (HTx).RESULTS: During the first post-HTx year, the mean intima thickness (IT) increased by 24.0 +/- 34.2 mu m (p < 0.001) and lumen area decreased by -0.9 +/- 1.8 mm2 (p < 0.001). The rs1570360 (A/G) SNP of the vascular endothelial growth factor A (VEGFA) gene showed the strongest association with intima thickness progression, even in the presence of the traditional CAV risk factors. SNPs previously related to carotid artery intima-media thickness rs11785239 (PRAG1), rs6584389 (PAX2), rs13225723 (LINC02577) and rs17477177 (CCDC71L), were among the five most significantly associated with IT progression but lost their significance once traditional CAV risk factors had been added.CONCLUSION: Results of this study suggest that genetic variability may play an important role in CAV development. The vascular endothelial growth factor A gene SNP rs1570360 showed the strongest association with intima thickness (IT) progression measured by OCT, even in the presence of the traditional CAV risk factors (Tab. 3, Fig. 3, Ref. 36). Text in PDF www.elis.sk
ER  -

MAYEROVA, Lucie, Anna CHALOUPKA, Peter WOHLFAHRT, Jaroslav Alois HUBACEK, Helena BEDANOVA, Zhi CHEN, Josef KAUTZNER, Vojtech MELENOVSKY, Ivan MALEK, Ales TOMASEK, Eva OZÁBALOVÁ, Jan KREJČÍ, Tomas KOVARNIK, Milan SONKA a Michal PAZDERNIK. Role of genetics in the development of cardiac allograft vasculopathy. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2023, roč.~124, č.~3, s.~193-200. ISSN~0006-9248. Dostupné z: https://dx.doi.org/10.4149/BLL\_{}2023\_{}031.

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