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@article{2339097,
author = {Malaník, Milan and Čulenová, Marie and Sychrová, Alice and Skiba, Adrianna and SkalickaandWozniak, Krystyna and Šmejkal, Karel},
article_location = {BASEL},
article_number = {8},
doi = {http://dx.doi.org/10.3390/ph16081061},
keywords = {epilepsy; anticonvulsant; natural products; GABA; AMPA; NMDA},
language = {eng},
issn = {1424-8247},
journal = {PHARMACEUTICALS},
title = {Treating Epilepsy with Natural Products: Nonsense or Possibility?},
url = {https://www.mdpi.com/1424-8247/16/8/1061},
volume = {16},
year = {2023}
}
TY - JOUR
ID - 2339097
AU - Malaník, Milan - Čulenová, Marie - Sychrová, Alice - Skiba, Adrianna - Skalicka-Wozniak, Krystyna - Šmejkal, Karel
PY - 2023
TI - Treating Epilepsy with Natural Products: Nonsense or Possibility?
JF - PHARMACEUTICALS
VL - 16
IS - 8
SP - 1-22
EP - 1-22
PB - MDPI
SN - 14248247
KW - epilepsy
KW - anticonvulsant
KW - natural products
KW - GABA
KW - AMPA
KW - NMDA
UR - https://www.mdpi.com/1424-8247/16/8/1061
N2 - Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness. Although modern medicine has effective antiepileptic drugs, the need for accessible and cost-effective medication is urgent, and products derived from plants could offer a solution. For this review, we have focused on natural compounds that have shown anticonvulsant activity in in vivo models of epilepsy at relevant doses. In some cases, the effects have been confirmed by clinical data. The results of our search are summarized in tables according to their molecular targets. We have critically evaluated the data we present, identified the most promising therapeutic candidates, and discussed these in the text. Their perspectives are supported by both pharmacokinetic properties and potential interactions. This review is intended to serve as a basis for future research into epilepsy and related disorders.
ER -
MALANÍK, Milan, Marie ČULENOVÁ, Alice SYCHROVÁ, Adrianna SKIBA, Krystyna SKALICKA-WOZNIAK a Karel ŠMEJKAL. Treating Epilepsy with Natural Products: Nonsense or Possibility? \textit{PHARMACEUTICALS}. BASEL: MDPI, 2023, roč.~16, č.~8, s.~1-22. ISSN~1424-8247. Dostupné z: https://dx.doi.org/10.3390/ph16081061.
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