Role of the microbiome in pathophysiology of necrotising
enterocolitis in preterm neonates

J 2023

Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

STANÍKOVÁ, Andrea, Martin JOUZA, Júlia BOHOŠOVÁ, Ondřej SLABÝ, Petr JABANDŽIEV et. al.

Základní údaje

Originální název

Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

Autoři

STANÍKOVÁ, Andrea (703 Slovensko, domácí), Martin JOUZA (203 Česká republika, domácí), Júlia BOHOŠOVÁ (703 Slovensko, domácí), Ondřej SLABÝ (203 Česká republika, domácí) a Petr JABANDŽIEV (203 Česká republika, garant, domácí)

Vydání

BMJ Paediatrics Open, LONDON, BMJ PUBLISHING GROUP, 2023, 2399-9772

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600 v roce 2022

Kód RIV

RIV/00216224:14110/23:00132253

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1136/bmjpo-2023-002172

UT WoS

001099840500001

Klíčová slova anglicky

microbiome; necrotising enterocolitis; preterm neonates

Štítky

14110317, 14110513, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 1. 2024 09:00, Mgr. Tereza Miškechová

Anotace

V originále

Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC’s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it.

Citovat

STANÍKOVÁ, Andrea, Martin JOUZA, Júlia BOHOŠOVÁ, Ondřej SLABÝ a Petr JABANDŽIEV. Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates. BMJ Paediatrics Open. LONDON: BMJ PUBLISHING GROUP, 2023, roč. 7, č. 1, s. 1-8. ISSN 2399-9772. Dostupné z: https://dx.doi.org/10.1136/bmjpo-2023-002172.

@article{2339478,
   author = {Staníková, Andrea and Jouza, Martin and Bohošová, Júlia and Slabý, Ondřej and Jabandžiev, Petr},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1136/bmjpo-2023-002172},
   keywords = {microbiome; necrotising enterocolitis; preterm neonates},
   language = {eng},
   issn = {2399-9772},
   journal = {BMJ Paediatrics Open},
   title = {Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates},
   url = {https://bmjpaedsopen.bmj.com/content/7/1/e002172},
   volume = {7},
   year = {2023}
}

TY  - JOUR
ID  - 2339478
AU  - Staníková, Andrea - Jouza, Martin - Bohošová, Júlia - Slabý, Ondřej - Jabandžiev, Petr
PY  - 2023
TI  - Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates
JF  - BMJ Paediatrics Open
VL  - 7
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - BMJ PUBLISHING GROUP
SN  - 23999772
KW  - microbiome
KW  - necrotising enterocolitis
KW  - preterm neonates
UR  - https://bmjpaedsopen.bmj.com/content/7/1/e002172
N2  - Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC’s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it.
ER  -

STANÍKOVÁ, Andrea, Martin JOUZA, Júlia BOHOŠOVÁ, Ondřej SLABÝ a Petr JABANDŽIEV. Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates. \textit{BMJ Paediatrics Open}. LONDON: BMJ PUBLISHING GROUP, 2023, roč.~7, č.~1, s.~1-8. ISSN~2399-9772. Dostupné z: https://dx.doi.org/10.1136/bmjpo-2023-002172.

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