Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides
on Intestinal Microbial Communities

D 2023

Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities

NIKOLAEVA, Vanina, Tomáš GONĚC, Ivan KUSHKEVYCH a Josef JAMPILEK

Základní údaje

Originální název

Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities

Autoři

NIKOLAEVA, Vanina (100 Bulharsko, domácí), Tomáš GONĚC (203 Česká republika, domácí), Ivan KUSHKEVYCH (203 Česká republika, domácí) a Josef JAMPILEK

Vydání

Basel, The 27th International Electronic Conference on Synthetic Organic Chemistry, od s. 1-5, 5 s. 2023

Nakladatel

MDPI

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Odkazy

URL

Kód RIV

RIV/00216224:14310/23:00132340

Organizační jednotka

Přírodovědecká fakulta

ISSN

DOI

http://dx.doi.org/10.3390/ecsoc-27-16142

Klíčová slova anglicky

hydroxynaphthalenecarboxamides; synthesis; enterobacteriaceae; antibacterial activity

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 2. 2024 17:17, Mgr. Marie Šípková, DiS.

Anotace

V originále

The phylum Proteobacteria, more precisely the family Enterobacteriacea, has been shown to be a major cause of inflammation in the human microbiome. Their standard level in the human intestine is usually kept below 1% in a healthy person, and their overgrowth above this number leads to intestinal inflammation, which can cause the development of inflammatory bowel diseases - most often Crohn's disease or ulcerative colitis. The minimum inhibitory concentrations (MICs) of a series of eighteen recently synthesized N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides were determined against two representatives of the Enterobacteriaceae family – Escherichia coli CCM 3954 and Salmonella typhimurium LT 2-18. Although the tested compounds are cyclic analogs of salicylanilides known to have strong antimicrobial properties, the minimum inhibitory concentrations found were in the range between 50 µM and 1000 µM. However, it can be concluded that S. typhimurium was generally more sensitive to the tested antimicrobial agents than E .coli. N-[2-(But-2-yloxy)phenyl]-1-hydroxynaphthalene-2-carboxamide was the most active of the compounds with an MIC of 100 µM against pro E. coli and an MIC of 50 µM against S. typhimurium.

Návaznosti

MUNI/A/1210/2022, interní kód MU

Název: Syntéza a studium derivátů kyseliny skořicové.

Investor: Masarykova univerzita, Syntéza a studium derivátů kyseliny skořicové.

MUNI/A/1280/2022, interní kód MU

Název: Podpora výzkumné činnosti studentů Mikrobiologie 3

Investor: Masarykova univerzita, Podpora výzkumné činnosti studentů Mikrobiologie 3

MUNI/A/1502/2023, interní kód MU

Název: Podpora výzkumné činnosti studentů Mikrobiologie 4

Investor: Masarykova univerzita, Podpora výzkumné činnosti studentů Mikrobiologie 4

Citovat

NIKOLAEVA, Vanina, Tomáš GONĚC, Ivan KUSHKEVYCH a Josef JAMPILEK. Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities. Online. In The 27th International Electronic Conference on Synthetic Organic Chemistry. Basel: MDPI, 2023, s. 1-5. ISSN 2673-4583. Dostupné z: https://dx.doi.org/10.3390/ecsoc-27-16142.

@inproceedings{2342040,
   author = {Nikolaeva, Vanina and Goněc, Tomáš and Kushkevych, Ivan and Jampilek, Josef},
   address = {Basel},
   booktitle = {The 27th International Electronic Conference on Synthetic Organic Chemistry},
   doi = {http://dx.doi.org/10.3390/ecsoc-27-16142},
   keywords = {hydroxynaphthalenecarboxamides; synthesis; enterobacteriaceae; antibacterial activity},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Basel},
   pages = {1-5},
   publisher = {MDPI},
   title = {Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities},
   url = {https://doi.org/10.3390/ecsoc-27-16142},
   year = {2023}
}

TY  - JOUR
ID  - 2342040
AU  - Nikolaeva, Vanina - Goněc, Tomáš - Kushkevych, Ivan - Jampilek, Josef
PY  - 2023
TI  - Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities
PB  - MDPI
CY  - Basel
KW  - hydroxynaphthalenecarboxamides
KW  - synthesis
KW  - enterobacteriaceae
KW  - antibacterial activity
UR  - https://doi.org/10.3390/ecsoc-27-16142
N2  - The phylum Proteobacteria, more precisely the family Enterobacteriacea, has been shown to be a major cause of inflammation in the human microbiome. Their standard level in the human intestine is usually kept below 1% in a healthy person, and their overgrowth above this number leads to intestinal inflammation, which can cause the development of inflammatory bowel diseases - most often Crohn's disease or ulcerative colitis. The minimum inhibitory concentrations (MICs) of a series of eighteen recently synthesized N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides were determined against two representatives of the Enterobacteriaceae family – Escherichia coli CCM 3954 and Salmonella typhimurium LT 2-18. Although the tested compounds are cyclic analogs of salicylanilides known to have strong antimicrobial properties, the minimum inhibitory concentrations found were in the range between 50 µM and 1000 µM. However, it can be concluded that S. typhimurium was generally more sensitive to the tested antimicrobial agents than E .coli. N-[2-(But-2-yloxy)phenyl]-1-hydroxynaphthalene-2-carboxamide was the most active of the compounds with an MIC of 100 µM against pro E. coli and an MIC of 50 µM against S. typhimurium.
ER  -

NIKOLAEVA, Vanina, Tomáš GONĚC, Ivan KUSHKEVYCH a Josef JAMPILEK. Effects of N-(Alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides on Intestinal Microbial Communities. Online. In \textit{The 27th International Electronic Conference on Synthetic Organic Chemistry}. Basel: MDPI, 2023, s.~1-5. ISSN~2673-4583. Dostupné z: https://dx.doi.org/10.3390/ecsoc-27-16142.

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