| DUBOVÝ, Petr, Ivana SVÍŽENSKÁ, Radim JANČÁLEK, Ilona KLUSÁKOVÁ, Ladislav HOUŠŤAVA a Pavel HANINEC. Immunohistochemical localization of laminin-1 in the acellular nerve grafts is associated with migrating Schwann cells which display corresponding integrin receptors. General Physiology and Biophysics. Bratislava: Veda, 1999, roč. 18, č. 1, s. 63-65. ISSN 0231-5882. |
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@article{234931,
author = {Dubový, Petr and Svíženská, Ivana and Jančálek, Radim and Klusáková, Ilona and Houšťava, Ladislav and Haninec, Pavel},
article_location = {Bratislava},
article_number = {1},
keywords = {Acellular nerve graft; Integrins; Laminin-1; Schwann cell migration},
language = {eng},
issn = {0231-5882},
journal = {General Physiology and Biophysics},
title = {Immunohistochemical localization of laminin-1 in the acellular nerve grafts is associated with migrating Schwann cells which display corresponding integrin receptors},
volume = {18},
year = {1999}
}
TY - JOUR
ID - 234931
AU - Dubový, Petr - Svíženská, Ivana - Jančálek, Radim - Klusáková, Ilona - Houšťava, Ladislav - Haninec, Pavel
PY - 1999
TI - Immunohistochemical localization of laminin-1 in the acellular nerve grafts is associated with migrating Schwann cells which display corresponding integrin receptors
JF - General Physiology and Biophysics
VL - 18
IS - 1
SP - 63
EP - 63
PB - Veda
SN - 02315882
KW - Acellular nerve graft
KW - Integrins
KW - Laminin-1
KW - Schwann cell migration
N2 - The presence of laminin-1, collagen-IV, a6 and b1 integrin chains was detected by indirect immunohistochemistry using biotin/streptavidin/HRP or gold-conjugated secondary antibody at the light and electron microscope level, respectively. Cryo-treated segment of the peripheral stump without living Schwann cells (S-100-) did not display immunoreactivity for laminin-1 and integrin's chains, while the migrating Schwann cells in the marginal regions were immunostained for the antigens. Isolated acellular nerve segments protected from migration of Schwann cells (S-100-) exhibited laminin-l-, b1-, and a6- integrin chains immunoreactivities. Position of the basal lamina was verified by collagen-IV+ immunoreactivity. Results indicate that presence of the laminin in the peripheral nerve is related with living Schwann cells.
ER -
DUBOVÝ, Petr, Ivana SVÍŽENSKÁ, Radim JANČÁLEK, Ilona KLUSÁKOVÁ, Ladislav HOUŠŤAVA a Pavel HANINEC. Immunohistochemical localization of laminin-1 in the acellular nerve grafts is associated with migrating Schwann cells which display corresponding integrin receptors. \textit{General Physiology and Biophysics}. Bratislava: Veda, 1999, roč.~18, č.~1, s.~63-65. ISSN~0231-5882.
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