SorCS2 binds progranulin to regulate motor neuron development

J 2023

SorCS2 binds progranulin to regulate motor neuron development

THOMASEN, Pernille Bogetofte, Alena SALASOVA, Kasper KJAER-SORENSEN, Lucie WOLOSZCZUKOVA, Josef LAVICKÝ et. al.

Základní údaje

Originální název

SorCS2 binds progranulin to regulate motor neuron development

Autoři

THOMASEN, Pernille Bogetofte, Alena SALASOVA, Kasper KJAER-SORENSEN, Lucie WOLOSZCZUKOVA, Josef LAVICKÝ (203 Česká republika, domácí), Hande LOGIN, Jeppe TRANBERG-JENSEN, Sergio ALMEIDA, Sander BEEL, Michaela KAVKOVÁ (203 Česká republika, domácí), Per QVIST, Mads KJOLBY, Peter Lund OVESEN, Stella NOLTE, Benedicte VESTERGAARD, Andreea-Cornelia UDREA, Lene Niemann NEJSUM, Moses V CHAO, Van Damme PHILIP, Jan KŘIVÁNEK (203 Česká republika, domácí), Jeremy DASEN, Claus OXVIG a Anders NYKJAER

Vydání

Cell Reports, CAMBRIDGE, Cell Press, 2023, 2211-1247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10605 Developmental biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.800 v roce 2022

Kód RIV

RIV/00216224:14110/23:00132520

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.celrep.2023.113333

UT WoS

001104229200001

Klíčová slova anglicky

motor neurons; SorCS2; progranulin; neurotrophic signaling; VPS10p-D receptors; neurodevelopment; nerve injury; light-sheet microscopy; image segmentation; zebrafish

Štítky

14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2024 10:44, Mgr. Tereza Miškechová

Anotace

V originále

Motor neuron (MN) development and nerve regeneration requires orchestrated action of a vast number of molecules. Here, we identify SorCS2 as a progranulin (PGRN) receptor that is required for MN diversification and axon outgrowth in zebrafish and mice. In zebrafish, SorCS2 knockdown also affects neuromuscular junction morphology and fish motility. In mice, SorCS2 and PGRN are co-expressed by newborn MNs from embryonic day 9.5 until adulthood. Using cell-fate tracing and nerve segmentation, we find that SorCS2 deficiency perturbs cell-fate decisions of brachial MNs accompanied by innervation deficits of posterior nerves. Additionally, adult SorCS2 knockout mice display slower motor nerve regeneration. Interestingly, primitive macrophages express high levels of PGRN, and their interaction with SorCS2-positive motor axon is required during axon pathfinding. We further show that SorCS2 binds PGRN to control its secretion, signaling, and conversion into granulins. We propose that PGRN-SorCS2 signaling controls MN development and regeneration in vertebrates.

Návaznosti

GA23-06160S, projekt VaV

Název: Fluktuace mikroprostředí kmenových buněk jako zdroj tkáňové adaptability ve zdraví a nemoci

Investor: Grantová agentura ČR, Fluktuace mikroprostředí kmenových buněk jako zdroj tkáňové adaptability ve zdraví a nemoci

LM2023050, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech BioImaging: Národní výzkumná infrastruktura pro biologické a medicínské zobrazování

90250, velká výzkumná infrastruktura

Název: Czech-BioImaging III

Citovat

THOMASEN, Pernille Bogetofte, Alena SALASOVA, Kasper KJAER-SORENSEN, Lucie WOLOSZCZUKOVA, Josef LAVICKÝ, Hande LOGIN, Jeppe TRANBERG-JENSEN, Sergio ALMEIDA, Sander BEEL, Michaela KAVKOVÁ, Per QVIST, Mads KJOLBY, Peter Lund OVESEN, Stella NOLTE, Benedicte VESTERGAARD, Andreea-Cornelia UDREA, Lene Niemann NEJSUM, Moses V CHAO, Van Damme PHILIP, Jan KŘIVÁNEK, Jeremy DASEN, Claus OXVIG a Anders NYKJAER. SorCS2 binds progranulin to regulate motor neuron development. Cell Reports. CAMBRIDGE: Cell Press, 2023, roč. 42, č. 11, s. 1-34. ISSN 2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2023.113333.

@article{2349460,
   author = {Thomasen, Pernille Bogetofte and Salasova, Alena and KjaerandSorensen, Kasper and Woloszczukova, Lucie and Lavický, Josef and Login, Hande and TranbergandJensen, Jeppe and Almeida, Sergio and Beel, Sander and Kavková, Michaela and Qvist, Per and Kjolby, Mads and Ovesen, Peter Lund and Nolte, Stella and Vestergaard, Benedicte and Udrea, AndreeaandCornelia and Nejsum, Lene Niemann and Chao, Moses V and Philip, Van Damme and Křivánek, Jan and Dasen, Jeremy and Oxvig, Claus and Nykjaer, Anders},
   article_location = {CAMBRIDGE},
   article_number = {11},
   doi = {http://dx.doi.org/10.1016/j.celrep.2023.113333},
   keywords = {motor neurons; SorCS2; progranulin; neurotrophic signaling; VPS10p-D receptors; neurodevelopment; nerve injury; light-sheet microscopy; image segmentation; zebrafish},
   language = {eng},
   issn = {2211-1247},
   journal = {Cell Reports},
   title = {SorCS2 binds progranulin to regulate motor neuron development},
   url = {https://www.sciencedirect.com/science/article/pii/S2211124723013451},
   volume = {42},
   year = {2023}
}

TY  - JOUR
ID  - 2349460
AU  - Thomasen, Pernille Bogetofte - Salasova, Alena - Kjaer-Sorensen, Kasper - Woloszczukova, Lucie - Lavický, Josef - Login, Hande - Tranberg-Jensen, Jeppe - Almeida, Sergio - Beel, Sander - Kavková, Michaela - Qvist, Per - Kjolby, Mads - Ovesen, Peter Lund - Nolte, Stella - Vestergaard, Benedicte - Udrea, Andreea-Cornelia - Nejsum, Lene Niemann - Chao, Moses V - Philip, Van Damme - Křivánek, Jan - Dasen, Jeremy - Oxvig, Claus - Nykjaer, Anders
PY  - 2023
TI  - SorCS2 binds progranulin to regulate motor neuron development
JF  - Cell Reports
VL  - 42
IS  - 11
SP  - 1-34
EP  - 1-34
PB  - Cell Press
SN  - 22111247
KW  - motor neurons
KW  - SorCS2
KW  - progranulin
KW  - neurotrophic signaling
KW  - VPS10p-D receptors
KW  - neurodevelopment
KW  - nerve injury
KW  - light-sheet microscopy
KW  - image segmentation
KW  - zebrafish
UR  - https://www.sciencedirect.com/science/article/pii/S2211124723013451
N2  - Motor neuron (MN) development and nerve regeneration requires orchestrated action of a vast number of molecules. Here, we identify SorCS2 as a progranulin (PGRN) receptor that is required for MN diversification and axon outgrowth in zebrafish and mice. In zebrafish, SorCS2 knockdown also affects neuromuscular junction morphology and fish motility. In mice, SorCS2 and PGRN are co-expressed by newborn MNs from embryonic day 9.5 until adulthood. Using cell-fate tracing and nerve segmentation, we find that SorCS2 deficiency perturbs cell-fate decisions of brachial MNs accompanied by innervation deficits of posterior nerves. Additionally, adult SorCS2 knockout mice display slower motor nerve regeneration. Interestingly, primitive macrophages express high levels of PGRN, and their interaction with SorCS2-positive motor axon is required during axon pathfinding. We further show that SorCS2 binds PGRN to control its secretion, signaling, and conversion into granulins. We propose that PGRN-SorCS2 signaling controls MN development and regeneration in vertebrates.
ER  -

THOMASEN, Pernille Bogetofte, Alena SALASOVA, Kasper KJAER-SORENSEN, Lucie WOLOSZCZUKOVA, Josef LAVICKÝ, Hande LOGIN, Jeppe TRANBERG-JENSEN, Sergio ALMEIDA, Sander BEEL, Michaela KAVKOVÁ, Per QVIST, Mads KJOLBY, Peter Lund OVESEN, Stella NOLTE, Benedicte VESTERGAARD, Andreea-Cornelia UDREA, Lene Niemann NEJSUM, Moses V CHAO, Van Damme PHILIP, Jan KŘIVÁNEK, Jeremy DASEN, Claus OXVIG a Anders NYKJAER. SorCS2 binds progranulin to regulate motor neuron development. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2023, roč.~42, č.~11, s.~1-34. ISSN~2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2023.113333.

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