Serum concentrations of proinflammatory biomarker interleukin-6
(IL-6) as a predictor of postoperative complications after
elective colorectal surgery

J 2023

Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery

PROCHÁZKA, Vladimír; Lukáš LACINA; Karel SMETANA; Martin SVOBODA; Kateřina SKŘIVANOVÁ et. al.

Základní údaje

Originální název

Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery

Autoři

PROCHÁZKA, Vladimír (203 Česká republika, domácí); Lukáš LACINA (203 Česká republika); Karel SMETANA (203 Česká republika); Martin SVOBODA (203 Česká republika, domácí); Kateřina SKŘIVANOVÁ (203 Česká republika); Miroslava BEŇOVSKÁ (203 Česká republika, domácí); Jiří JARKOVSKÝ (203 Česká republika, domácí); Leoš KŘEN (203 Česká republika, domácí) a Zdeněk KALA (203 Česká republika, domácí)

Vydání

World Journal of Surgical Oncology, LONDON, BMC, 2023, 1477-7819

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.500

Kód RIV

RIV/00216224:14110/23:00132557

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1186/s12957-023-03270-9

UT WoS

001126542200003

EID Scopus

2-s2.0-85179662889

Klíčová slova anglicky

Interleukin-6; Postoperative complications; Colorectal surgery; Infection

Štítky

14110223, 14110230, 14110616, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 1. 2024 13:50, Mgr. Tereza Miškechová

Anotace

V originále

Background The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery. Method A total of 115 patients underwent colorectal surgery for malignancy. IL-6 was measured on the first and third postoperative days (POD1, POD3), and C-reactive protein (CRP) was measured on the POD3. POC was analysed in subgroups according to Clavien‒Dindo (CD), antibiotic (ATB) treatment, intensive care unit (ICU) and hospital length of stay. The predictive power of variables for evaluated endpoints was analysed using receiver-operating characteristic (ROC) analysis and described by area under the curve (AUC). ROC analysis was adopted for the identification of optimal cut-offs. Histological analysis was performed to verify IL-6 production by the tumour. Results Out of 115 patients who were analysed, 42% had POC. Patients with POC had significantly higher serum levels of IL-6 on POD1 (p < 0.001) and POD3 (p < 0.001). IL-6 early on POD1 as a predictor of antibiotic treatment, ICU stay and hospital stay (AUC 0.818; 0.811; 0.771) did not significantly differ from the AUC of CRP late on POD3 (0.879; 0.838, 0.752). A cut-off IL-6 value of 113 pg/ml on POD1 and 180.5 pg/ml on POD3 in severe complications (CD > 3a) resulted in 75% and 72% sensitivity, 78.6% and 99% specificity, negative predictive value 96.4% and 97% and positive predictive value 29% and 88.9%. Conclusion The serum level of interleukin-6 can predict severe (CD > 3a) POC early on POD1. On POD3, IL-6 is superior to CRP in terms of high positive predictive power of severe POC. Interestingly, the advantage of IL-6 on POD1 is early prediction of the need for antibiotic treatment, ICU stay and hospital stay, which is comparable to the CRP serum level late on the third POD.

Návaznosti

LX22NPO5102, projekt VaV

Název: Národní ústav pro výzkum rakoviny (Akronym: NÚVR)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní ústav pro výzkum rakoviny, 5.1 EXCELES

Přiložené soubory

Serum_concentrations_of_proinflammatory_biomarker_interleukin-6__IL-6__as_a_predictor_of_postoperative_complications_after_elective_colorectal_surgery.pdf

Citovat

PROCHÁZKA, Vladimír; Lukáš LACINA; Karel SMETANA; Martin SVOBODA; Kateřina SKŘIVANOVÁ; Miroslava BEŇOVSKÁ; Jiří JARKOVSKÝ; Leoš KŘEN a Zdeněk KALA. Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery. World Journal of Surgical Oncology. LONDON: BMC, 2023, roč. 21, č. 1, s. 1-11. ISSN 1477-7819. Dostupné z: https://doi.org/10.1186/s12957-023-03270-9.

@article{2351118,
   author = {Procházka, Vladimír and Lacina, Lukáš and Smetana, Karel and Svoboda, Martin and Skřivanová, Kateřina and Beňovská, Miroslava and Jarkovský, Jiří and Křen, Leoš and Kala, Zdeněk},
   article_location = {LONDON},
   article_number = {1},
   doi = {https://doi.org/10.1186/s12957-023-03270-9},
   keywords = {Interleukin-6; Postoperative complications; Colorectal surgery; Infection},
   language = {eng},
   issn = {1477-7819},
   journal = {World Journal of Surgical Oncology},
   title = {Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery},
   url = {https://wjso.biomedcentral.com/articles/10.1186/s12957-023-03270-9},
   volume = {21},
   year = {2023}
}

TY  - JOUR
ID  - 2351118
AU  - Procházka, Vladimír - Lacina, Lukáš - Smetana, Karel - Svoboda, Martin - Skřivanová, Kateřina - Beňovská, Miroslava - Jarkovský, Jiří - Křen, Leoš - Kala, Zdeněk
PY  - 2023
TI  - Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery
JF  - World Journal of Surgical Oncology
VL  - 21
IS  - 1
SP  - 1-11
EP  - 1-11
PB  - BMC
SN  - 14777819
KW  - Interleukin-6
KW  - Postoperative complications
KW  - Colorectal surgery
KW  - Infection
UR  - https://wjso.biomedcentral.com/articles/10.1186/s12957-023-03270-9
N2  - Background The aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery. Method A total of 115 patients underwent colorectal surgery for malignancy. IL-6 was measured on the first and third postoperative days (POD1, POD3), and C-reactive protein (CRP) was measured on the POD3. POC was analysed in subgroups according to Clavien‒Dindo (CD), antibiotic (ATB) treatment, intensive care unit (ICU) and hospital length of stay. The predictive power of variables for evaluated endpoints was analysed using receiver-operating characteristic (ROC) analysis and described by area under the curve (AUC). ROC analysis was adopted for the identification of optimal cut-offs. Histological analysis was performed to verify IL-6 production by the tumour. Results Out of 115 patients who were analysed, 42% had POC. Patients with POC had significantly higher serum levels of IL-6 on POD1 (p < 0.001) and POD3 (p < 0.001). IL-6 early on POD1 as a predictor of antibiotic treatment, ICU stay and hospital stay (AUC 0.818; 0.811; 0.771) did not significantly differ from the AUC of CRP late on POD3 (0.879; 0.838, 0.752). A cut-off IL-6 value of 113 pg/ml on POD1 and 180.5 pg/ml on POD3 in severe complications (CD > 3a) resulted in 75% and 72% sensitivity, 78.6% and 99% specificity, negative predictive value 96.4% and 97% and positive predictive value 29% and 88.9%. Conclusion The serum level of interleukin-6 can predict severe (CD > 3a) POC early on POD1. On POD3, IL-6 is superior to CRP in terms of high positive predictive power of severe POC. Interestingly, the advantage of IL-6 on POD1 is early prediction of the need for antibiotic treatment, ICU stay and hospital stay, which is comparable to the CRP serum level late on the third POD.
ER  -

PROCHÁZKA, Vladimír; Lukáš LACINA; Karel SMETANA; Martin SVOBODA; Kateřina SKŘIVANOVÁ; Miroslava BEŇOVSKÁ; Jiří JARKOVSKÝ; Leoš KŘEN a Zdeněk KALA. Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery. \textit{World Journal of Surgical Oncology}. LONDON: BMC, 2023, roč.~21, č.~1, s.~1-11. ISSN~1477-7819. Dostupné z: https://doi.org/10.1186/s12957-023-03270-9.

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