Antarctic soil bacteria – unprecedented potential to produce
novel secondary metabolites

k 2022

Antarctic soil bacteria – unprecedented potential to produce novel secondary metabolites

BEZDÍČEK KRÁLOVÁ, Stanislava, Songcan CHEN, Mathias FLIEDER, Peter ŠPAČEK, Matěj BEZDÍČEK et. al.

Základní údaje

Originální název

Antarctic soil bacteria – unprecedented potential to produce novel secondary metabolites

Autoři

BEZDÍČEK KRÁLOVÁ, Stanislava (703 Slovensko, garant, domácí), Songcan CHEN (156 Čína), Mathias FLIEDER (40 Rakousko), Peter ŠPAČEK (703 Slovensko), Matěj BEZDÍČEK (203 Česká republika), Jana HANSLIKOVÁ (203 Česká republika), Martin ZEHL (40 Rakousko), Sergey ZOTCHEV (643 Rusko), Thomas RATTEI (276 Německo) a Alexander LOY (276 Německo)

Vydání

29th Congress of the CSSM, 2022

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

10606 Microbiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/22:00132597

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

Antarktida; biosynteticky potencial; antimikrobiální látky; rezistence

Klíčová slova anglicky

Antarctica; biosynthetic potential; antimicrobial compounds; resistance

Změněno: 20. 12. 2023 09:44, RNDr. Stanislava Bezdíček Králová, Ph.D.

Anotace

V originále

Discovering novel antimicrobial compounds is one of the priorities of current and future medicine in response to increasing levels of multidrug-resistant pathogens. The vast majority of antimicrobials is derived from microbes. Recent years of antimicrobial research showed that extreme habitats and unexplored or yet uncultivated microorganisms dwelling there might represent the most promising sources of novel antimicrobials. This study, which is linked to the MetaBac platform at the University of Vienna, aims to explore Antarctic soil bacterial isolates as a source of novel natural products with antimicrobial activities. Multiple isolation methods have been applied to obtain pure cultures of novel taxa from Antarctic soils; with focus on taxa known for their remarkable secondary metabolite biosynthesis potential. Initial stages of this research aimed to taxonomically classify all isolates and evaluate their biosynthetic potential. As a result, a collection of 623, mostly slow growing isolates was established. More than 60% of these strains belonged to the phyla Actinobacteriota and Bacillota, including several novel species (Streptomyces, Nocardioides, Dietzia, Paenibacillus). Pseudomonadota was the next most abundant group in the strain collection. Current steps based on these results include experiments with representatives of several novel Streptomyces spp. including cultivation in different conditions along with analysis of their metabolomes and immediate evaluation of antimicrobial activities against clinically relevant yeasts, gram-negative and gram-positive bacteria.

Návaznosti

LM2015078, projekt VaV

Název: Česká polární výzkumná infrastruktura (Akronym: CzechPolar2)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech Polar Research Infrastructure

Citovat

BEZDÍČEK KRÁLOVÁ, Stanislava, Songcan CHEN, Mathias FLIEDER, Peter ŠPAČEK, Matěj BEZDÍČEK, Jana HANSLIKOVÁ, Martin ZEHL, Sergey ZOTCHEV, Thomas RATTEI a Alexander LOY. Antarctic soil bacteria – unprecedented potential to produce novel secondary metabolites. In 29th Congress of the CSSM. 2022.

@proceedings{2351901,
   author = {Bezdíček Králová, Stanislava and Chen, Songcan and Flieder, Mathias and Špaček, Peter and Bezdíček, Matěj and Hansliková, Jana and Zehl, Martin and Zotchev, Sergey and Rattei, Thomas and Loy, Alexander},
   booktitle = {29th Congress of the CSSM},
   keywords = {Antarctica; biosynthetic potential; antimicrobial compounds; resistance},
   language = {eng},
   title = {Antarctic soil bacteria – unprecedented potential to produce novel secondary metabolites},
   year = {2022}
}

TY  - CONF
ID  - 2351901
AU  - Bezdíček Králová, Stanislava - Chen, Songcan - Flieder, Mathias - Špaček, Peter - Bezdíček, Matěj - Hansliková, Jana - Zehl, Martin - Zotchev, Sergey - Rattei, Thomas - Loy, Alexander
PY  - 2022
TI  - Antarctic soil bacteria – unprecedented potential to produce novel secondary metabolites
KW  - Antarctica
KW  - biosynthetic potential
KW  - antimicrobial compounds
KW  - resistance
N2  - Discovering novel antimicrobial compounds is one of the priorities of current and future medicine in response to increasing levels of multidrug-resistant pathogens. The vast majority of antimicrobials is derived from microbes. Recent years of antimicrobial research showed that extreme habitats and unexplored or yet uncultivated microorganisms dwelling there might represent the most promising sources of novel antimicrobials. This study, which is linked to the MetaBac platform at the University of Vienna, aims to explore Antarctic soil bacterial isolates as a source of novel natural products with antimicrobial activities. Multiple isolation methods have been applied to obtain pure cultures of novel taxa from Antarctic soils; with focus on taxa known for their remarkable secondary metabolite biosynthesis potential. Initial stages of this research aimed to taxonomically classify all isolates and evaluate their biosynthetic potential. As a result, a collection of 623, mostly slow growing isolates was established. More than 60% of these strains belonged to the phyla Actinobacteriota and Bacillota, including several novel species (Streptomyces, Nocardioides, Dietzia, Paenibacillus). Pseudomonadota was the next most abundant group in the strain collection. Current steps based on these results include experiments with representatives of several novel Streptomyces spp. including cultivation in different conditions along with analysis of their metabolomes and immediate evaluation of antimicrobial activities against clinically relevant yeasts, gram-negative and gram-positive bacteria.
ER  -

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