MASURI, Sebastiano, Maria Grazia CABIDDU, Lukáš MORÁŇ, Tereza VESSELÁ, Martin BARTOSIK, Josef HAVEL, Francesca MELONI, Enzo CADONI, Petr VAŇHARA a Tiziana PIVETTA. Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers. New Journal of Chemistry. Cambridge: ROYAL SOC. CHEMISTRY, 2023, roč. 47, č. 32, s. 15125-15136. ISSN 1144-0546. Dostupné z: https://dx.doi.org/10.1039/d3nj01317k. |
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@article{2352399, author = {Masuri, Sebastiano and Cabiddu, Maria Grazia and Moráň, Lukáš and Vesselá, Tereza and Bartosik, Martin and Havel, Josef and Meloni, Francesca and Cadoni, Enzo and Vaňhara, Petr and Pivetta, Tiziana}, article_location = {Cambridge}, article_number = {32}, doi = {http://dx.doi.org/10.1039/d3nj01317k}, keywords = {BIOLOGICAL-ACTIVITY; CYTOTOXIC ACTIVITY; CRYSTAL-STRUCTURE; SDNA-BINDING; CELL-DEATH; CISPLATINPLATINUM; LIGANDS; SYSTEM; ACID}, language = {eng}, issn = {1144-0546}, journal = {New Journal of Chemistry}, title = {Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers}, url = {https://pubs.rsc.org/en/content/articlelanding/2023/NJ/D3NJ01317K}, volume = {47}, year = {2023} }
TY - JOUR ID - 2352399 AU - Masuri, Sebastiano - Cabiddu, Maria Grazia - Moráň, Lukáš - Vesselá, Tereza - Bartosik, Martin - Havel, Josef - Meloni, Francesca - Cadoni, Enzo - Vaňhara, Petr - Pivetta, Tiziana PY - 2023 TI - Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers JF - New Journal of Chemistry VL - 47 IS - 32 SP - 15125-15136 EP - 15125-15136 PB - ROYAL SOC. CHEMISTRY SN - 11440546 KW - BIOLOGICAL-ACTIVITY KW - CYTOTOXIC ACTIVITY KW - CRYSTAL-STRUCTURE KW - SDNA-BINDING KW - CELL-DEATH KW - CISPLATINPLATINUM KW - LIGANDS KW - SYSTEM KW - ACID UR - https://pubs.rsc.org/en/content/articlelanding/2023/NJ/D3NJ01317K N2 - We prepared six complexes with the formula [Cu(phen)(2)(Lx)](ClO4)(x: 1-6), where auxiliary ligands Lx are coumarin carboxylate derivatives bearing an oxylacetate moiety in the 6th or 7th position and different substituents in the 3rd or 4th position. Complexes show a pentacoordinated geometry around a metal ion. The possibility to complete the coordination sphere in an octahedral geometry makes the molecule able to further react. Complexes show affinity toward DNA mainly through electrostatic interactions and groove binding, while the interactions with DNA base pairs are guaranteed by the auxiliary ligands. The heteroleptic Cu(ii) complexes show cytotoxic activity in the micromolar concentration range, and mechanistic studies have shown how they can interfere at the endothelial reticulum level inducing the pro-apoptotic branch of the unfolded protein response (UPR). The actin-normalized CHOP to BiP density ratios suggest that the novel compounds induce preferentially the pro-apoptotic UPR signalling driven by the CHOP, in a dose-dependent way and according to the substituents in the coumarin moiety. ER -
MASURI, Sebastiano, Maria Grazia CABIDDU, Lukáš MORÁŇ, Tereza VESSELÁ, Martin BARTOSIK, Josef HAVEL, Francesca MELONI, Enzo CADONI, Petr VAŇHARA a Tiziana PIVETTA. Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers. \textit{New Journal of Chemistry}. Cambridge: ROYAL SOC. CHEMISTRY, 2023, roč.~47, č.~32, s.~15125-15136. ISSN~1144-0546. Dostupné z: https://dx.doi.org/10.1039/d3nj01317k.
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