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@article{2352478,
author = {Stepankova, Hana and Michalkova, Hana and Splichal, Zbynek and Richtera, Lukas and Svec, Pavel and Vaculovič, Tomáš and Přibyl, Jan and Kormunda, Martin and Rex, Simona and Adam, Vojtech and Heger, Zbynek},
article_location = {PEOPLES R CHINA},
article_number = {FEB},
doi = {http://dx.doi.org/10.1016/j.bioactmat.2022.06.014},
keywords = {Aspect ratio; Biocompatibility; Nanotoxicology; Nanorods},
language = {eng},
issn = {2452-199X},
journal = {BIOACTIVE MATERIALS},
title = {Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology},
url = {https://sciencedirect.com/science/article/pii/S2452199X22002808?via%3Dihub},
volume = {20},
year = {2023}
}
TY - JOUR
ID - 2352478
AU - Stepankova, Hana - Michalkova, Hana - Splichal, Zbynek - Richtera, Lukas - Svec, Pavel - Vaculovič, Tomáš - Přibyl, Jan - Kormunda, Martin - Rex, Simona - Adam, Vojtech - Heger, Zbynek
PY - 2023
TI - Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology
JF - BIOACTIVE MATERIALS
VL - 20
IS - FEB
SP - 489-500
EP - 489-500
PB - KEAI PUBLISHING LTD
SN - 2452199X
KW - Aspect ratio
KW - Biocompatibility
KW - Nanotoxicology
KW - Nanorods
UR - https://sciencedirect.com/science/article/pii/S2452199X22002808?via%3Dihub
N2 - Although the general concept of nanotechnology relies on exploitation of size-dependent properties of nano -scaled materials, the relation between the size/morphology of nanoparticles with their biological activity re-mains not well understood. Therefore, we aimed at investigating the biological activity of Se nanoparticles, one of the most promising candidates of nanomaterials for biomedicine, possessing the same crystal structure, but differing in morphology (nanorods vs. spherical particles) and aspect ratios (AR, 11.5 vs. 22.3 vs. 1.0) in human cells and BALB/c mice. Herein, we report that in case of nanorod-shaped Se nanomaterials, AR is a critical factor describing their cytotoxicity and biocompatibility. However, spherical nanoparticles (AR 1.0) do not fit this statement and exhibit markedly higher cytotoxicity than lower-AR Se nanorods. Beside of cytotoxicity, we also show that morphology and size substantially affect the uptake and intracellular fate of Se nanomaterials. In line with in vitro data, in vivo i.v. administration of Se nanomaterials revealed the highest toxicity for higher-AR nanorods followed by spherical nanoparticles and lower-AR nanorods. Moreover, we revealed that Se nano -materials are able to alter intracellular redox homeostasis, and affect the acidic intracellular vesicles and cyto-skeletal architecture in a size-and morphology-dependent manner. Although the tested nanoparticles were produced from the similar sources, their behavior differs markedly, since each type is promising for several various application scenarios, and the presented testing protocol could serve as a concept standardizing the biological relevance of the size and morphology of the various types of nanomaterials and nanoparticles.
ER -
STEPANKOVA, Hana, Hana MICHALKOVA, Zbynek SPLICHAL, Lukas RICHTERA, Pavel SVEC, Tomáš VACULOVIČ, Jan PŘIBYL, Martin KORMUNDA, Simona REX, Vojtech ADAM a Zbynek HEGER. Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology. \textit{BIOACTIVE MATERIALS}. PEOPLES R CHINA: KEAI PUBLISHING LTD, 2023, roč.~20, FEB, s.~489-500. ISSN~2452-199X. Dostupné z: https://dx.doi.org/10.1016/j.bioactmat.2022.06.014.
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