SALÁT, Jiří, Milan HUNADY, Pavel SVOBODA, Lucie STŘELCOVÁ, Petra STRAKOVÁ, Andrea FOŘTOVÁ, Martin PALUS a Daniel RŮŽEK. Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs. Vaccine. Elsevier Ltd, 2023, roč. 41, č. 42, s. 6150-6155. ISSN 0264-410X. Dostupné z: https://dx.doi.org/10.1016/j.vaccine.2023.09.019. |
Další formáty:
BibTeX
LaTeX
RIS
@article{2353803, author = {Salát, Jiří and Hunady, Milan and Svoboda, Pavel and Střelcová, Lucie and Straková, Petra and Fořtová, Andrea and Palus, Martin and Růžek, Daniel}, article_number = {42}, doi = {http://dx.doi.org/10.1016/j.vaccine.2023.09.019}, keywords = {Tick-borne encephalitis; Vaccine; Dogs}, language = {eng}, issn = {0264-410X}, journal = {Vaccine}, title = {Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs}, url = {https://doi.org/10.1016/j.vaccine.2023.09.019}, volume = {41}, year = {2023} }
TY - JOUR ID - 2353803 AU - Salát, Jiří - Hunady, Milan - Svoboda, Pavel - Střelcová, Lucie - Straková, Petra - Fořtová, Andrea - Palus, Martin - Růžek, Daniel PY - 2023 TI - Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs JF - Vaccine VL - 41 IS - 42 SP - 6150-6155 EP - 6150-6155 PB - Elsevier Ltd SN - 0264410X KW - Tick-borne encephalitis KW - Vaccine KW - Dogs UR - https://doi.org/10.1016/j.vaccine.2023.09.019 N2 - Tick-borne encephalitis (TBE) is a severe neuroinfection of humans. Dogs are also commonly infected with tick-borne encephalitis virus (TBEV). These infections are usually asymptomatic, but sometimes show clinical signs similar to those seen in humans and can be fatal. To date, there is no TBEV vaccine available for use in dogs. To address this need, a TBEV vaccine candidate for dogs based on inactivated whole virus antigen was developed. The safety, immunogenicity, and efficacy of the vaccine candidate were tested in mice as the preclinical model and in dogs as the target organism. The vaccine was well tolerated in both species and elicited the production of specific anti-TBEV antibodies with virus neutralising activity. Vaccination of mice provided complete protection against the development of fatal TBE. Immunisation of dogs prevented the development of viremia after challenge infection. Therefore, the developed vaccine candidate is promising to protect dogs from severe TBEV infections. ER -
SALÁT, Jiří, Milan HUNADY, Pavel SVOBODA, Lucie STŘELCOVÁ, Petra STRAKOVÁ, Andrea FOŘTOVÁ, Martin PALUS a Daniel RŮŽEK. Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs. \textit{Vaccine}. Elsevier Ltd, 2023, roč.~41, č.~42, s.~6150-6155. ISSN~0264-410X. Dostupné z: https://dx.doi.org/10.1016/j.vaccine.2023.09.019.
|