Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside
Analogues.

J 2023

Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues.

PENJARLA, Srishylam, Paidi Yella REDDY, Santhosh PENTA, Yogesh S SANGHVI, Luděk EYER et. al.

Základní údaje

Originální název

Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues.

Autoři

PENJARLA, Srishylam, Paidi Yella REDDY, Santhosh PENTA, Yogesh S SANGHVI, Luděk EYER (203 Česká republika, domácí), Michal ŠTEFÁNIK, Zuzana KRÁTKA (703 Slovensko, domácí), Daniel RŮŽEK (203 Česká republika) a Shyamapada BANERJEE

Vydání

ChemistrySelect, Wiley, 2023, 2365-6549

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10606 Microbiology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.100 v roce 2022

Kód RIV

RIV/00216224:14310/23:00132674

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/slct.202303585

UT WoS

001128722500001

Klíčová slova anglicky

Antiviral Agent; L-2 2'-anhydrouridine; L-Arabinose; Cytotoxicity; L-Nucleoside

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 1. 2024 15:01, Mgr. Marie Šípková, DiS.

Anotace

V originále

Nucleoside analogues have been the foundation of antiviral therapy over the past few decades. D-nucleosides with natural stereochemistry occupies the lion share of the marketed antiviral agents. However, much less effort have been put towards the development of L-nucleosides as antiviral agents. Herein, our effort towards the synthesis of 2′ -substituted L-nucleoside analogues is reported as an emerging class of antiviral agents. Biological activity of the synthesized L-nucleosided was evaluated against two viruses of importance, tick-borne encephalitis virus (TBEV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in adenocarcinomic human alveolar basal epithelial cells (A459) and Vero cells. Ring opening of L-2, 2′-Anhydrouridine (2) with various nucleophiles to make several 2‘-substituted L-nucleosides is the key synthetic outcome. This development has paved the way in the synthesis of many new analogues of 2‘-substituted L-nucleosides for numerous applications.

Návaznosti

LM2018127, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii (Akronym: CIISB)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech Infrastructure for Integrative Structural Biology

Citovat

PENJARLA, Srishylam, Paidi Yella REDDY, Santhosh PENTA, Yogesh S SANGHVI, Luděk EYER, Michal ŠTEFÁNIK, Zuzana KRÁTKA, Daniel RŮŽEK a Shyamapada BANERJEE. Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues. ChemistrySelect. Wiley, 2023, roč. 8, č. 48, s. 1-11. ISSN 2365-6549. Dostupné z: https://dx.doi.org/10.1002/slct.202303585.

@article{2353818,
   author = {Penjarla, Srishylam and Reddy, Paidi Yella and Penta, Santhosh and Sanghvi, Yogesh S and Eyer, Luděk and Štefánik, Michal and Krátka, Zuzana and Růžek, Daniel and Banerjee, Shyamapada},
   article_number = {48},
   doi = {http://dx.doi.org/10.1002/slct.202303585},
   keywords = {Antiviral Agent; L-2 2'-anhydrouridine; L-Arabinose; Cytotoxicity; L-Nucleoside},
   language = {eng},
   issn = {2365-6549},
   journal = {ChemistrySelect},
   title = {Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues.},
   url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202303585},
   volume = {8},
   year = {2023}
}

TY  - JOUR
ID  - 2353818
AU  - Penjarla, Srishylam - Reddy, Paidi Yella - Penta, Santhosh - Sanghvi, Yogesh S - Eyer, Luděk - Štefánik, Michal - Krátka, Zuzana - Růžek, Daniel - Banerjee, Shyamapada
PY  - 2023
TI  - Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues.
JF  - ChemistrySelect
VL  - 8
IS  - 48
SP  - 1-11
EP  - 1-11
PB  - Wiley
SN  - 23656549
KW  - Antiviral Agent
KW  - L-2 2'-anhydrouridine
KW  - L-Arabinose
KW  - Cytotoxicity
KW  - L-Nucleoside
UR  - https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202303585
N2  - Nucleoside analogues have been the foundation of antiviral therapy over the past few decades. D-nucleosides with natural stereochemistry occupies the lion share of the marketed antiviral agents. However, much less effort have been put towards the development of L-nucleosides as antiviral agents. Herein, our effort towards the synthesis of 2′ -substituted L-nucleoside analogues is reported as an emerging class of antiviral agents. Biological activity of the synthesized L-nucleosided was evaluated against two viruses of importance, tick-borne encephalitis virus (TBEV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in adenocarcinomic human alveolar basal epithelial cells (A459) and Vero cells. Ring opening of L-2, 2′-Anhydrouridine (2) with various nucleophiles to make several 2‘-substituted L-nucleosides is the key synthetic outcome. This development has paved the way in the synthesis of many new analogues of 2‘-substituted L-nucleosides for numerous applications.
ER  -

PENJARLA, Srishylam, Paidi Yella REDDY, Santhosh PENTA, Yogesh S SANGHVI, Luděk EYER, Michal ŠTEFÁNIK, Zuzana KRÁTKA, Daniel RŮŽEK a Shyamapada BANERJEE. Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues. \textit{ChemistrySelect}. Wiley, 2023, roč.~8, č.~48, s.~1-11. ISSN~2365-6549. Dostupné z: https://dx.doi.org/10.1002/slct.202303585.

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