LÖRINCZ, Eszter Boglárka, Mihály HERCZEG, Josef HOUSER, Martina RIEVAJOVÁ, Ákos KUKI, Lenka MALINOVSKÁ, Lieve NAESENS, Michaela WIMMEROVÁ, Anikó BORBÁS, Pál HERCZEGH a Ilona BERECZKI. Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase. International Journal of Molecular Sciences. MDPI, 2023, roč. 24, č. 24, s. 1-23. ISSN 1661-6596. Dostupné z: https://dx.doi.org/10.3390/ijms242417268. |
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@article{2354958, author = {Lörincz, Eszter Boglárka and Herczeg, Mihály and Houser, Josef and Rievajová, Martina and Kuki, Ákos and Malinovská, Lenka and Naesens, Lieve and Wimmerová, Michaela and Borbás, Anikó and Herczegh, Pál and Bereczki, Ilona}, article_number = {24}, doi = {http://dx.doi.org/10.3390/ijms242417268}, keywords = {influenza; sialic acid; neuraminidase; hemagglutinin; aggregates}, language = {eng}, issn = {1661-6596}, journal = {International Journal of Molecular Sciences}, title = {Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase}, url = {https://www.mdpi.com/1422-0067/24/24/17268}, volume = {24}, year = {2023} }
TY - JOUR ID - 2354958 AU - Lörincz, Eszter Boglárka - Herczeg, Mihály - Houser, Josef - Rievajová, Martina - Kuki, Ákos - Malinovská, Lenka - Naesens, Lieve - Wimmerová, Michaela - Borbás, Anikó - Herczegh, Pál - Bereczki, Ilona PY - 2023 TI - Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase JF - International Journal of Molecular Sciences VL - 24 IS - 24 SP - 1-23 EP - 1-23 PB - MDPI SN - 16616596 KW - influenza KW - sialic acid KW - neuraminidase KW - hemagglutinin KW - aggregates UR - https://www.mdpi.com/1422-0067/24/24/17268 N2 - Blocking viral hemagglutinin with multivalent N-acetylneuraminic acid derivatives is a promising approach to prevent influenza infection. Moreover, dual inhibition of both hemagglutinin and neuraminidase may result in a more powerful effect. Since both viral glycoproteins can bind to neuraminic acid, we have prepared three series of amphiphilic self-assembling 2-thio-neuraminic acid derivatives constituting aggregates in aqueous medium to take advantage of their multivalent effect. One of the series was prepared by the azide-alkyne click reaction, and the other two by the thio-click reaction to yield neuraminic acid derivatives containing lipophilic tails of different sizes and an enzymatically stable thioglycosidic bond. Two of the three bis-octyl derivatives produced proved to be active against influenza viruses, while all three octyl derivatives bound to hemagglutinin and neuraminidase from H1N1 and H3N2 influenza types. ER -
LÖRINCZ, Eszter Boglárka, Mihály HERCZEG, Josef HOUSER, Martina RIEVAJOVÁ, Ákos KUKI, Lenka MALINOVSKÁ, Lieve NAESENS, Michaela WIMMEROVÁ, Anikó BORBÁS, Pál HERCZEGH a Ilona BERECZKI. Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase. \textit{International Journal of Molecular Sciences}. MDPI, 2023, roč.~24, č.~24, s.~1-23. ISSN~1661-6596. Dostupné z: https://dx.doi.org/10.3390/ijms242417268.
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