Selected neuroendocrine factors as potential molecular
biomarkers of early non-affective psychosis course in relation
to treatment outcome: A pilot study

J 2023

Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study

OBDRŽÁLKOVÁ, Marie, Libor USTOHAL, Natasa HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ et. al.

Základní údaje

Originální název

Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study

Autoři

OBDRŽÁLKOVÁ, Marie (203 Česká republika, domácí), Libor USTOHAL (203 Česká republika, domácí), Natasa HLAVACOVA, Michaela MAYEROVÁ (203 Česká republika, domácí), Eva ČEŠKOVÁ (203 Česká republika, domácí), Tomáš KAŠPÁREK (203 Česká republika, domácí) a Daniela JEZOVA

Vydání

Heliyon, Oxford, Elsevier, 2023, 2405-8440

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30215 Psychiatry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.000 v roce 2022

Kód RIV

RIV/00216224:14110/23:00134686

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.heliyon.2023.e21173

UT WoS

001114112800001

Klíčová slova anglicky

Aldosterone; Cortisol; Non-affective psychosis

Štítky

14110222, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 1. 2024 09:09, Mgr. Tereza Miškechová

Anotace

V originále

The aim of this pilot study was to find whether the dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treat-ment outcome. Patients with the first episode of non-affective psychosis (N = 29) were examined at admission, at discharge, and at follow-up (N = 23). The biomarkers included serum aldoste-rone, cortisol, free thyroxine, thyroid stimulating hormone, and prolactin. We revealed lower baseline aldosterone and higher baseline cortisol concentrations in patients with very good outcome compared to those with good outcome after one year. We failed to reveal any significant association between treatment outcome and neurohumoral biomarkers in the whole sample at 1-year follow-up. However, baseline aldosterone concentrations negatively correlated with total PANSS scores at the discharge. Lower baseline aldosterone and higher baseline cortisol concentrations have the potential to predict a more favorable outcome for patients with the first episode of psychosis.

Návaznosti

NU23-08-00257, projekt VaV

Název: Optimalizovaný longitudinální vlasový kortizol jako nástroj v diagnostice a monitorování psychiatrických poruch

Investor: Ministerstvo zdravotnictví ČR, Optimalizovaný longitudinální vlasový kortizol jako nástroj v diagnostice a monitorování psychiatrických poruch, Podprogram 1 - standardní

Citovat

OBDRŽÁLKOVÁ, Marie, Libor USTOHAL, Natasa HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK a Daniela JEZOVA. Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study. Heliyon. Oxford: Elsevier, 2023, roč. 9, č. 10, s. 1-10. ISSN 2405-8440. Dostupné z: https://dx.doi.org/10.1016/j.heliyon.2023.e21173.

@article{2355288,
   author = {Obdržálková, Marie and Ustohal, Libor and Hlavacova, Natasa and Mayerová, Michaela and Češková, Eva and Kašpárek, Tomáš and Jezova, Daniela},
   article_location = {Oxford},
   article_number = {10},
   doi = {http://dx.doi.org/10.1016/j.heliyon.2023.e21173},
   keywords = {Aldosterone; Cortisol; Non-affective psychosis},
   language = {eng},
   issn = {2405-8440},
   journal = {Heliyon},
   title = {Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study},
   url = {https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub},
   volume = {9},
   year = {2023}
}

TY  - JOUR
ID  - 2355288
AU  - Obdržálková, Marie - Ustohal, Libor - Hlavacova, Natasa - Mayerová, Michaela - Češková, Eva - Kašpárek, Tomáš - Jezova, Daniela
PY  - 2023
TI  - Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study
JF  - Heliyon
VL  - 9
IS  - 10
SP  - 1-10
EP  - 1-10
PB  - Elsevier
SN  - 24058440
KW  - Aldosterone
KW  - Cortisol
KW  - Non-affective psychosis
UR  - https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub
N2  - The aim of this pilot study was to find whether the dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treat-ment outcome. Patients with the first episode of non-affective psychosis (N = 29) were examined at admission, at discharge, and at follow-up (N = 23). The biomarkers included serum aldoste-rone, cortisol, free thyroxine, thyroid stimulating hormone, and prolactin. We revealed lower baseline aldosterone and higher baseline cortisol concentrations in patients with very good outcome compared to those with good outcome after one year. We failed to reveal any significant association between treatment outcome and neurohumoral biomarkers in the whole sample at 1-year follow-up. However, baseline aldosterone concentrations negatively correlated with total PANSS scores at the discharge. Lower baseline aldosterone and higher baseline cortisol concentrations have the potential to predict a more favorable outcome for patients with the first episode of psychosis.
ER  -

OBDRŽÁLKOVÁ, Marie, Libor USTOHAL, Natasa HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK a Daniela JEZOVA. Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study. \textit{Heliyon}. Oxford: Elsevier, 2023, roč.~9, č.~10, s.~1-10. ISSN~2405-8440. Dostupné z: https://dx.doi.org/10.1016/j.heliyon.2023.e21173.

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