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@article{2355288,
author = {Obdržálková, Marie and Ustohal, Libor and Hlavacova, Natasa and Mayerová, Michaela and Češková, Eva and Kašpárek, Tomáš and Jezova, Daniela},
article_location = {Oxford},
article_number = {10},
doi = {http://dx.doi.org/10.1016/j.heliyon.2023.e21173},
keywords = {Aldosterone; Cortisol; Non-affective psychosis},
language = {eng},
issn = {2405-8440},
journal = {Heliyon},
title = {Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study},
url = {https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub},
volume = {9},
year = {2023}
}
TY - JOUR
ID - 2355288
AU - Obdržálková, Marie - Ustohal, Libor - Hlavacova, Natasa - Mayerová, Michaela - Češková, Eva - Kašpárek, Tomáš - Jezova, Daniela
PY - 2023
TI - Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study
JF - Heliyon
VL - 9
IS - 10
SP - 1-10
EP - 1-10
PB - Elsevier
SN - 24058440
KW - Aldosterone
KW - Cortisol
KW - Non-affective psychosis
UR - https://www.sciencedirect.com/science/article/pii/S2405844023083810?via%3Dihub
N2 - The aim of this pilot study was to find whether the dysregulation of neuroendocrine biomarker signaling pathways in the first episode of non-affective psychosis is a predictive factor of treat-ment outcome. Patients with the first episode of non-affective psychosis (N = 29) were examined at admission, at discharge, and at follow-up (N = 23). The biomarkers included serum aldoste-rone, cortisol, free thyroxine, thyroid stimulating hormone, and prolactin. We revealed lower baseline aldosterone and higher baseline cortisol concentrations in patients with very good outcome compared to those with good outcome after one year. We failed to reveal any significant association between treatment outcome and neurohumoral biomarkers in the whole sample at 1-year follow-up. However, baseline aldosterone concentrations negatively correlated with total PANSS scores at the discharge. Lower baseline aldosterone and higher baseline cortisol concentrations have the potential to predict a more favorable outcome for patients with the first episode of psychosis.
ER -
OBDRŽÁLKOVÁ, Marie, Libor USTOHAL, Natasa HLAVACOVA, Michaela MAYEROVÁ, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK a Daniela JEZOVA. Selected neuroendocrine factors as potential molecular biomarkers of early non-affective psychosis course in relation to treatment outcome: A pilot study. \textit{Heliyon}. Oxford: Elsevier, 2023, roč.~9, č.~10, s.~1-10. ISSN~2405-8440. Dostupné z: https://dx.doi.org/10.1016/j.heliyon.2023.e21173.
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