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@article{2355878,
author = {Guma, Elisa and Andrýsková, Lenka and Brázdil, Milan and Chakravarty, M. Mallar and Marečková, Klára},
article_number = {March},
doi = {http://dx.doi.org/10.1016/j.pnpbp.2022.110676},
keywords = {Maternal anxiety; Perinatal depression; Amygdala; Volume; Surface area},
language = {eng},
issn = {0278-5846},
journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
title = {Perinatal maternal mental health and amygdala morphology in young adulthood},
url = {https://doi.org/10.1016/j.pnpbp.2022.110676},
volume = {122},
year = {2023}
}
TY - JOUR
ID - 2355878
AU - Guma, Elisa - Andrýsková, Lenka - Brázdil, Milan - Chakravarty, M. Mallar - Marečková, Klára
PY - 2023
TI - Perinatal maternal mental health and amygdala morphology in young adulthood
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
VL - 122
IS - March
SP - 1-8
EP - 1-8
PB - Elsevier
SN - 02785846
KW - Maternal anxiety
KW - Perinatal depression
KW - Amygdala
KW - Volume
KW - Surface area
UR - https://doi.org/10.1016/j.pnpbp.2022.110676
N2 - The pre- and perinatal environment is thought to play a critical role in shaping brain development. Specifically, maternal mental health and maternal care have been shown to influence offspring brain development in regions implicated in emotional regulation such as the amygdala. In this study, we used data from a neuroimaging follow-up of a prenatal birth-cohort, the European Longitudinal Study of Pregnancy and Childhood, to investigate the impact of early postnatal maternal anxiety/co-dependence, and prenatal and early-postnatal depression and dysregulated mood on amygdala volume and morphology in young adulthood (n = 103). We observed that in typically developing young adults, greater maternal anxiety/co-dependence after birth was significantly associated with lower volume (right: t = −2.913, p = 0.0045, β = −0.523; left: t = −1.471, p = 0.144, β = −0.248) and non-significantly associated with surface area (right: t = −3.502, q = 0.069, <10%FDR, β = −0.090, left: t = −3.137, q = 0.117, <10%FDR, = −0.088) of the amygdala in young adulthood. Conversely, prenatal maternal depression and mood dysregulation in the early postnatal period was not associated with any volumetric or morphological changes in the amygdala in young adulthood. Our findings provide evidence for subtle but long-lasting alterations to amygdala morphology associated with differences in maternal anxiety/co-dependence in early development.
ER -
GUMA, Elisa, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, M. Mallar CHAKRAVARTY a Klára MAREČKOVÁ. Perinatal maternal mental health and amygdala morphology in young adulthood. \textit{Progress in Neuro-Psychopharmacology and Biological Psychiatry}. Elsevier, 2023, roč.~122, March, s.~1-8. ISSN~0278-5846. Dostupné z: https://dx.doi.org/10.1016/j.pnpbp.2022.110676.
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