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@article{2358720,
author = {Macholán, Miloš and Daniszova, Kristina and Hiadlovska, Zuzana},
article_number = {11},
doi = {http://dx.doi.org/10.3390/genes14112090},
keywords = {copy number variation; ddPCR; MUP excretion; Mus musculus; proteomics; synanthropy},
language = {eng},
issn = {2073-4425},
journal = {Genes},
title = {The Expansion of House Mouse Major Urinary Protein Genes Likely Did Not Facilitate Commensalism with Humans},
url = {https://doi.org/10.3390/genes14112090},
volume = {14},
year = {2023}
}
TY - JOUR
ID - 2358720
AU - Macholán, Miloš - Daniszova, Kristina - Hiadlovska, Zuzana
PY - 2023
TI - The Expansion of House Mouse Major Urinary Protein Genes Likely Did Not Facilitate Commensalism with Humans
JF - Genes
VL - 14
IS - 11
SP - 1-14
EP - 1-14
PB - MDPI
SN - 20734425
KW - copy number variation
KW - ddPCR
KW - MUP excretion
KW - Mus musculus
KW - proteomics
KW - synanthropy
UR - https://doi.org/10.3390/genes14112090
N2 - Mouse wild-derived strains (WDSs) combine the advantages of classical laboratory stocks and wild animals, and thus appear to be promising tools for diverse biomedical and evolutionary studies. We employed 18 WDSs representing three non-synanthropic species (Mus spretus, Mus spicilegus, and M. macedonicus) and three house mouse subspecies (Mus musculus musculus, M. m. domesticus, M. m. castaneus), which are all important human commensals to explore whether the number of major urinary protein (MUP) genes and their final protein levels in urine are correlated with the level of commensalism. Contrary to expectations, the MUP copy number (CN) and protein excretion in the strains derived from M. m. castaneus, which is supposed to be the strongest commensal, were not significantly different from the non-commensal species. Regardless of an overall tendency for higher MUP amounts in taxa with a higher CN, there was no significant correlation at the strain level. Our study thus suggests that expansion of the Mup cluster, which appeared before the house mouse diversification, is unlikely to facilitate commensalism with humans in three house mouse subspecies. Finally, we found considerable variation among con(sub)specific WDSs, warning against generalisations of results based on a few strains.
ER -
MACHOLÁN, Miloš, Kristina DANISZOVA a Zuzana HIADLOVSKA. The Expansion of House Mouse Major Urinary Protein Genes Likely Did Not Facilitate Commensalism with Humans. \textit{Genes}. MDPI, 2023, roč.~14, č.~11, s.~1-14. ISSN~2073-4425. Dostupné z: https://dx.doi.org/10.3390/genes14112090.
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