The effect of deep brain stimulation in Parkinson's disease
reflected in EEG microstates

J 2023

The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates

LAMOŠ, Martin, Martina BOČKOVÁ, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ, Jan CHRASTINA et. al.

Základní údaje

Originální název

The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates

Autoři

LAMOŠ, Martin (203 Česká republika, domácí), Martina BOČKOVÁ (203 Česká republika, domácí), Sabina GOLDEMUNDOVÁ (203 Česká republika, domácí), Marek BALÁŽ (703 Slovensko, domácí), Jan CHRASTINA (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, garant, domácí)

Vydání

NPJ PARKINSONS DISEASE, BERLIN, NATURE PORTFOLIO, 2023, 2373-8057

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.700 v roce 2022

Kód RIV

RIV/00216224:14740/23:00132933

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1038/s41531-023-00508-x

UT WoS

000989780900001

Klíčová slova anglicky

deep brain stimulation; high-density EEG; Parkinson's disease; EEG microstates

Štítky

14110127, 14110131, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 10. 2024 08:55, Mgr. Adéla Pešková

Anotace

V originále

Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson's disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson's disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson's disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS.

Návaznosti

NU21-04-00445, projekt VaV

Název: Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit (Akronym: DBScomorbidities)

Investor: Ministerstvo zdravotnictví ČR, Klinická odpovídavost na STN-DBS u Parkinsonovy nemoci: vliv vaskulárních, kardiovaskulárních, metabolických a zánětlivých komorbidit, Podprogram 1 - standardní

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

LAMOŠ, Martin, Martina BOČKOVÁ, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ, Jan CHRASTINA a Ivan REKTOR. The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates. NPJ PARKINSONS DISEASE. BERLIN: NATURE PORTFOLIO, 2023, roč. 9, č. 1, s. 1-7. ISSN 2373-8057. Dostupné z: https://dx.doi.org/10.1038/s41531-023-00508-x.

@article{2359337,
   author = {Lamoš, Martin and Bočková, Martina and Goldemundová, Sabina and Baláž, Marek and Chrastina, Jan and Rektor, Ivan},
   article_location = {BERLIN},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41531-023-00508-x},
   keywords = {deep brain stimulation; high-density EEG; Parkinson's disease; EEG microstates},
   language = {eng},
   issn = {2373-8057},
   journal = {NPJ PARKINSONS DISEASE},
   title = {The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates},
   url = {https://www.nature.com/articles/s41531-023-00508-x},
   volume = {9},
   year = {2023}
}

TY  - JOUR
ID  - 2359337
AU  - Lamoš, Martin - Bočková, Martina - Goldemundová, Sabina - Baláž, Marek - Chrastina, Jan - Rektor, Ivan
PY  - 2023
TI  - The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates
JF  - NPJ PARKINSONS DISEASE
VL  - 9
IS  - 1
SP  - 1-7
EP  - 1-7
PB  - NATURE PORTFOLIO
SN  - 23738057
KW  - deep brain stimulation
KW  - high-density EEG
KW  - Parkinson's disease
KW  - EEG microstates
UR  - https://www.nature.com/articles/s41531-023-00508-x
N2  - Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson's disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson's disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson's disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS.
ER  -

LAMOŠ, Martin, Martina BOČKOVÁ, Sabina GOLDEMUNDOVÁ, Marek BALÁŽ, Jan CHRASTINA a Ivan REKTOR. The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates. \textit{NPJ PARKINSONS DISEASE}. BERLIN: NATURE PORTFOLIO, 2023, roč.~9, č.~1, s.~1-7. ISSN~2373-8057. Dostupné z: https://dx.doi.org/10.1038/s41531-023-00508-x.

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