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@proceedings{2360009, author = {Hoferková, Eva and Kadáková, Soňa and Šeda, Václav and Verner, Jan and Boudný, Miroslav and Mladonická Pavlasová, Gabriela and Loja, Tomáš and Filip, Daniel and Večeřa, Josef and Matulová, Květoslava and Skuhrová Francová, Hana and Sharma, Sonali and Ondrišová, Laura and Palušová, Veronika and Vojtová, Lucy and Křen, Leoš and Doubek, Michael and Mráz, Marek}, booktitle = {CEITEC PhD Conference 2023, Brno}, keywords = {Chronic lymphocytic leukemia; CD40L; IL4; IL21; inhibitors; proliferation}, language = {eng}, title = {Coculture model with CD40L, IL4 and IL21 for study chronic lymphocytic leukemia proliferation.}, url = {https://www.ceitec.eu/ceitec-phd-conference-2023/a4489}, year = {2023} }
TY - CONF ID - 2360009 AU - Hoferková, Eva - Kadáková, Soňa - Šeda, Václav - Verner, Jan - Boudný, Miroslav - Mladonická Pavlasová, Gabriela - Loja, Tomáš - Filip, Daniel - Večeřa, Josef - Matulová, Květoslava - Skuhrová Francová, Hana - Sharma, Sonali - Ondrišová, Laura - Palušová, Veronika - Vojtová, Lucy - Křen, Leoš - Doubek, Michael - Mráz, Marek PY - 2023 TI - Coculture model with CD40L, IL4 and IL21 for study chronic lymphocytic leukemia proliferation. KW - Chronic lymphocytic leukemia KW - CD40L KW - IL4 KW - IL21 KW - inhibitors KW - proliferation UR - https://www.ceitec.eu/ceitec-phd-conference-2023/a4489 N2 - Chronic lymphocytic leukemia (CLL) cells exhibit dynamic trafficking between the quiescent and activated states in the lymphoid microenvironment, where they proliferate in response to signals from CD4+ T cells. These signals can be mimicked in vitro with artificial stimulation by CD40L, IL4, and IL21. In this study, we generated a panel of HS5-derived cell lines expressing T cell factors, which induce CLL proliferation and support CLL survival. 30 Using a coculture model, microenvironment-targeting drugs with potential effects on CLL cell proliferation were tested. Specifically, clinically used inhibitors including ibrutinib and idelalisib, and some of them were found to significantly inhibit CLL proliferation, with a reduction of up to 50% in the number of proliferative cells observed. The effect was not influenced by increased apoptosis. ER -
HOFERKOVÁ, Eva, Soňa KADÁKOVÁ, Václav ŠEDA, Jan VERNER, Miroslav BOUDNÝ, Gabriela MLADONICKÁ PAVLASOVÁ, Tomáš LOJA, Daniel FILIP, Josef VEČEŘA, Květoslava MATULOVÁ, Hana SKUHROVÁ FRANCOVÁ, Sonali SHARMA, Laura ONDRIŠOVÁ, Veronika PALUŠOVÁ, Lucy VOJTOVÁ, Leoš KŘEN, Michael DOUBEK a Marek MRÁZ. Coculture model with CD40L, IL4 and IL21 for study chronic lymphocytic leukemia proliferation. In \textit{CEITEC PhD Conference 2023, Brno}. 2023.
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