A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation

SALOŇ, Adam, Ruslan NESHEV, Kaja TERAŽ, Boštjan ŠIMUNIČ, Manca PESKAR, Uroš MARUŠIČ, Saša PIŠOT, Luka ŠLOSAR, Mladen GASPARINI, Rado PIŠOT, Patrick DE BOEVER, Karin SCHMID-ZALAUDEK, Bianca STEUBER, Per Morten FREDRIKSEN, Benedicta Ngwenchi NKEH-CHUNGAG, Harald SOURIJ, Omar ŠERÝ a Nandu GOSWAMI. A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation. Microvascular Research. Academic Press Inc., 2023, roč. 150, November, s. 1-7. ISSN 0026-2862. Dostupné z: https://dx.doi.org/10.1016/j.mvr.2023.104588.

Základní údaje

Originální název

A pilot study: Exploring the influence of COVID-19 on cardiovascular physiology and retinal microcirculation

Autoři

SALOŇ, Adam (703 Slovensko, domácí), Ruslan NESHEV, Kaja TERAŽ, Boštjan ŠIMUNIČ, Manca PESKAR, Uroš MARUŠIČ, Saša PIŠOT, Luka ŠLOSAR, Mladen GASPARINI, Rado PIŠOT, Patrick DE BOEVER, Karin SCHMID-ZALAUDEK, Bianca STEUBER, Per Morten FREDRIKSEN, Benedicta Ngwenchi NKEH-CHUNGAG, Harald SOURIJ, Omar ŠERÝ (203 Česká republika, garant, domácí) a Nandu GOSWAMI

Vydání

Microvascular Research, Academic Press Inc. 2023, 0026-2862

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.100 v roce 2022

Kód RIV

RIV/00216224:14310/23:00133041

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.mvr.2023.104588

UT WoS

001049715900001

Klíčová slova anglicky

COVID-19; Circulation; Hemodynamics; Pulse wave analysis; Retina; Arterial stiffness; Microcirculation

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects the cardiovascular system. The current study investigated changes in heart rate (HR), blood pressure (BP), pulse wave velocity (PWV), and microcirculation in patients recovering from Coronavirus disease 2019 (COVID-19) infection. Methodology: Out of 43 initially contacted COVID-19 patients, 35 (30 males, 5 females; age: 60 ± 10 years; and body mass index (BMI): 31.8 ± 4.9) participated in this study. Participants were seen on two occasions after hospital discharge; the baseline measurements were collected, either on the day of hospital discharge if a negative PCR test was obtained, or on the 10th day after hospitalization if the PCR test was positive. The second measurements were done 60 days after hospitalization. The vascular measurements were performed using the VICORDER® device and a retinal blood vessel image analysis. Results: A significant increase in systolic BP (SBP) (from 142 mmHg, SD: 15, to 150 mmHg, SD: 19, p = 0.041), reduction in HR (from 76 bpm, SD: 15, to 69 bpm, SD: 11, p = 0.001), and narrower central retinal vein equivalent (CRVE) (from 240.94 μm, SD: 16.05, to 198.05 μm, SD: 17.36, p = 0.013) were found. Furthermore, the trends of increasing PWV (from 11 m/s, SD: 3, to 12 m/s, SD: 3, p = 0.095) and decreasing CRAE (from 138.87 μm, SD: 12.19, to 136.77 μm, SD: 13.19, p = 0.068) were recorded. Conclusion: The present study investigated cardiovascular changes following COVID-19 infection at two-time points after hospital discharge (baseline measurements and 60 days post-hospitalization). Significant changes were found in systolic blood pressure, heart rate, and microvasculature indicating that vascular adaptations may be ongoing even weeks after hospitalization from COVID-19 infection. Future studies could involve conducting additional interim assessments during the active infection and post-infection periods.